Biomedical subjects
Publications and source records attributed to G K Donovan.
Pyloric stenosis, a relatively common surgical problem in infancy, is often straightforward in its clinical presentation and diagnosis. Here we describe two unusual cases where the normal diagnostic measures failed, and an unusual alternative, endoscopy, was a means to the correct diagnosis.
The scarcity of donor organs results in the death of some pediatric transplant candidates while they wait for an organ. The use of anencephalic infants has been suggested as a way to increase the donor pool. Advantages and disadvantages of this approach are reviewed, and recommendations made for the state of Oklahoma.
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Soy protein formulas are often poorly tolerated by infants with chronic nonspecific or postinfectious diarrhea syndrome. We found that these adverse responses may be prevented by using lactose, instead of sucrose or dextrimaltose, in soy formula. We studied 40 infants diagnosed as soy intolerant. They were given soy formula with differing carbohydrate contents in a randomized, blinded prospective study. Stool output, stool sodium content, and symptoms were significantly improved in infants receiving a soy-lactose formula; no difference was seen in formulas with sucrose or maltose. Improvement occurred in three to five days in most infants. Furthermore, the characteristic frequency distribution of the favorable response to lactose suggested a specific mechanism for the inhibition of water and electrolyte losses through the bowel. The results indicate that, in the absence of lactose intolerance, a soy-lactose formula could be useful in treating chronic diarrhea and secondary protein intolerance.
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