[AIDS and mycobacterial infections].
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Biomedical subjects
Publications and source records attributed to G K Kovalev.
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A total of 777 specimens of the river-side and water birds of 36 species belonging to 8 orders were examined for infectivity by the causative agent of tuberculosis M. avium. Examination was carried out in the northern zone of the land along the lower Volga. Infectivity was studied by serologic and bacteriologic tests. Serologic examination showed that 104 out of the 399 birds were AIT-positive (26.0 +/- 2.195%), in bacteriologic examination 73 out of the 378 specimens were infected (19.57 +/- 2.040%). The infectivity parameters of birds determined by both methods had certain characteristic features typical of the examination territory. The character of distribution of the infected birds was determined according to the regions of the examination zone.
Examination for M. avium contamination covered 702 specimens of the synanthropic birds of 6 species (hooded crows, daws, rooks, magpies, sparrows, starlings) which was carried out in 13 landscape-epizootic areas of the northern zone of the Low Volga region. Contamination was studied by a serological test (AIT) using the M. avium extract and dry avian tuberculin as an antigen in the parallel tests. It was found that 96 (23%) of the 416 specimens from the right bank of the Volga and 65 (22.72%) of the 286 birds from the left bank were AIT-seropositive. The paper presents methods of study and contamination parameters of birds; the character of distribution of the infected birds by the region of the examination zone is discussed.
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Sensitivity of the glanders causative agent to 20 antibiotics representing different groups is described. The results of the in vitro studies showed that most of the antibiotics were not active against the glanders causative agent, except for polymyxin M, levomycetin and their combination. Some relative activity was observed with neomycin. The "indicators" method used by the authors for determination of the M. mallei sensitivity to the antibiotics allowed the shortening of the time of the test by 8 to 10 hours.
The authors present the results of in vitro determination of the sensitivity of the causative agent of glanders and melioidosis to 8 preparations-5-nitrofuran derivatives, and also to negram and PASK. The most active against M. mallei and Ps. pseudomallei were furazonal and furacrillin; negram was less active. No naturally resistanct strains to furacrylin and furazonal were revealed among the M. mallei and Ps. pseudomallei strains studied.