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Biomedical subjects

G K Mirodzhov

Publications and source records attributed to G K Mirodzhov.

At least 19 recordsLinked to original sources
PubMed2006

[The frequency and resistance of cytotoxin-associated (CAG-A) Helicobacter pylori strains to antibacterial agents in chronic gastritis and duodenal ulcer].

The authors of the study demonstrate that Helicobacter pylori (HP) strains with the cytoxin-associated protein Cag A are more frequent in patients suffering from duodenal ulcer (DU) or lymphocyte gastritis. DU is more severe and often displays a recurrent character in cases with persistent Cag A-positive HP strains. The authors studied the sensitivity of HP strains with the cytoxin-associated protein Cag A to various antibacterial preparations. The study shows that resistance of HP to metronidazole is found mostly among Cag A strains (58.5% of cases).

Adult↗
PubMed2005

[Clinical and morphological features of alcoholic steatohepatitis].

48 patients with alcoholic steatohepatitis (ASH) were examined and divided into 3 groups according to the degree of fatty liver infiltration. It was minimal in 8 (16. 6%) patients, moderate in 10 (20.8%) and severe in 30 (62.5%) patients. The higher the degree of the fatty infiltration, the more pronounced dystrophic alterations and the more often necrosis, fibrosis and cell infiltration focuses were found in liver biopsy material. Morphologic changes in biopsy samples from ASH patients were much more pronounced in comparison with those in non-alcoholic steatohepatitis (NASH). The latter is characterized mostly by lymphocyte infiltration, while leukocyte infiltration is more typical of ASH. The study found prominent alterations in serum lipoprotein spectrum, triglyceride (TG) and saturated fatty acid concentrations in patients with ASH. High concentrations of chylomicrons, low-density lipoproteins and TG were registered together with low levels of high-density lipoproteins and albumin complex.

Biomarkers↗
PubMed2005

[Insulin resistance in patients with metabolic syndrome and cholelithiasis].

The aim of the study was to determine serum insulin level in patients with metabolic syndrome (MS), pronounced manifestation of cholelithiasis (CL), and abdominal obesity. The measurements were compared with hyperlipidemia and glycemia levels in these patients. The subjects were 55 women with MS, divided into two groups according to 1991 Kh. Kh. Mansurov's classification of CL stages. Insulin level was measured by immune-enzyme assay; carbohydrate and lipid metabolism (lipid levels, lipoprotein and fatty acid spectrums, malonic dialdehyde and catalase levels)--by conventional methods. The study revealed a correlation between high insulin level in patients with hyperglycemia, disorder of tolerance to glucose, and type II diabetes, on the one hand, and lipid peroxidation level and dislipidemia, on the other. The study also found high insulin level at various stages of CL, especially during the period of concrement formation. Insulin is a CL risk factor, i.e. it elevates the risk of nucleation.

Adult↗
PubMed2005

[Cell immunity and hepatocyte apoptosis in chronic cholestatic hepatitis].

The aim of the study was to evaluate activity and accumulation of natural T-killers (NK-cells, CD16+) and lymphocytes with apoptosis marker (CD95+) in peripheral blood and hepatic tissue of patients with chronic viral hepatitis, in connection with presence or absence of cholestasis. The subjects were 14 patients suffering from chronic hepatitis (CH) without cholestasis, and 16--with CH and cholestasis, aged 18 to 56 years. The study revealed significant elevation of the number of NK-cells in hepatic tissue of CH patients with cholestasis, not only vs. controls, but also vs. CH patients without cholestasis. Accumulation of natural T-killers in hepatic tissues was accompanied by reduction of their absolute number in peripheral blood and increase of the number of apoptotic bodies in the liver. There was a positive correlation between parameters of apoptosis of hepatocytes, on the one part, and the number of regenerating hepatocytes and serum indicators of cholestasis, on the other.

Adolescent↗
PubMed2004

[Anti-Helicobacter therapy for duodenal peptic ulcer complicated by pyloroduodenal stenosis].

The rate of persistence of and susceptibility of Helicobacter pylori (HP) to antibacterial drugs (ABDs) and the results of eradication therapy were studied in patients with duodenal peptic ulcer complicated by pyloroduodenal stenosis (PDS). The patients with PDS exhibited a high (97.1%) rate of anthral mucosal infection with HP showing a high resistance to ABDs. The efficiency of eradication therapy performed with the susceptibility of HP to ABDs kept in mind was 92.5%. The use of eradication therapy in the complex preoperative preparation of patients with ulcerative PDS increases the latter.

Adult↗
PubMed2003

[Differential diagnosis of congenital fibrosis of the liver and hepatoportal sclerosis].

The article deals with differential-diagnostic criteria of inborn liver fibrosis and hepatoportal sclerosis. Congenital liver fibrosis is inherited and manifests at young age. It is characterized by marked hepatomegaly with stony dense liver, moderate splenomegaly with hypersplenism and portal hypertension in high activity of alkaline phosphatase and 5-HT, renal affection. Fibrosis locates around the biliary ducts. Hepatoportal sclerosis manifests more frequently in the adults with moderate hepatomegaly, marked splenomegaly with hypersplenism and predominance of anemia, high portal hypertension. Fibrosis is moderate and locates around portal vein branches in which thrombi are found.

Diagnosis, Differential↗
PubMed1991

[Effect of low-energy laser radiation on hepatocyte ploidy].

The effect of two types of low-energy laser radiation (He-Ne and infrared) was investigated. Both types had the same effect: stimulation of the liver regeneration due to active proliferation of the tetraploid and binuclear hepatocytes.

Animals↗
PubMed1991

[Liver sinusoidal cells: nature, functional characteristics, and cooperative relationships].

Morphological and functional features as well as cooperative relations of Kupffer's cells, endotheliocytes, lipocytes and pit-cells under normal and pathological conditions delineated in the literature are reviewed. It is shown that liver sinusoid cells protect the parenchyma, control hepatocyte regeneration, take part in the antitumor immunity, participate in the metabolism of lipids, lipoproteins, proteins, biogenic amines and collagen while the cooperative interaction between them and hepatocytes determines an interhepatic homeostasis.

Animals↗
PubMed1991

[Role of porphyrins in the development of alcohol-induced liver lesions].

To specify the role porphyrins play in the development of diffuse liver injuries, 53 patients with alcohol-induced liver injuries were examined. Of these, 17 patients manifested marked derangement of porphyrin metabolism. As a result of clinico-biochemical, immunological and morphological research methods, it is established that marked derangement of porphyrin metabolism manifesting itself in porphyrin deposition in hepatocytes and in the high level of uro and coproporphyrinuria is associated with the development of autoimmune reactions towards liver-specific lipoprotein, which determines the development of the grave forms of liver injury in patients who abuse alcohol.

Adult↗
PubMed1989

[A morphological evaluation of the preventive and therapeutic action of low-intensity laser radiation on the course of acute toxic hepatitis].

The optimal schedule of the preventive and therapeutical effect of helium-neon laser on the acute toxic hepatitis induced in rats by CCl4 is established. The laser dose of 5-10 mVt/cm2 for 5-10 min prevents the toxic hepatitis while therapeutical use of 7 to 10 such schedules reduces the intensity of the protein and fat degeneration, parenchymal necrosis and inflammatory infiltration.

Acute Disease↗
PubMed1989

[Markers of the hepatitis B virus in the blood serum and liver tissue in chronic diffuse diseases].

It is shown that the activity of the disease depends on the localisation of HBsAg and HBcAg in the hepatocyte and on the reaction of the delayed hypersensitivity (RDH) to HBsAg and liver-specific lipoprotein (LSL). RDH to HBsAg, LSL and a diffuse localisation of HBsAg in the hepatocyte cytoplasm are observed in the non-active chronic diffuse liver disease while the marginal or membraneous localisation of HBsAg which is frequently combined with HBcAg in nuclei and RDH to HBsAg and LSL are found in the active forms of chronic liver diseases.

Biomarkers↗
PubMed1988

[Cardinal problems of alcoholic diseases of the liver].

Proceeding from a clinicofunctional and morphological analysis of the liver state in 367 patients with different variants of alcoholic liver disease (ALD), the authors presented obligatory and optional morphological features of alcoholic hepatitis (AH); possible diagnostic difficulties of AH were considered. Two types-stages of alcoholic fibrosis--perivenous and pericellular fibrosis and chronic centrolobular sclerosis were proposed. Chronic active hepatitis of alcoholic etiology was considered as a nosological entity, different interrelationships of alcohol and hepatitis B virus were shown in ALD genesis.

Diagnosis, Differential↗
PubMed1985

[Evaluation of therapeutic effectiveness of prednisolone in patients with chronic active hepatitis based on the morphometry of liver biopsy specimens].

In 42 patients with chronic active hepatitis (CAH), liver biopsies were subjected to histological study and morphometry before and after prednisolone treatment (21 patients comprising group I) and treatment with a complex of vitamins B1, B6, B12 and C (21 patients comprising group II). Combined study of liver biopsies during treatment makes it possible to evaluate objectively enough the results of prednisolone therapy of CAH patients. The authors confirmed the efficacy of prednisolone therapy of patients with sero-negative CAH. These patients demonstrated a reduction in dystrophic alterations, volume of inflammatory cells in the portal tracts and in the areas of necrosis, a lowering of the number of aggressive lymphocytes. Prednisolone was discovered to have an adverse effect on seropositive CAH, to activate virus replication in liver tissue, intensify necrotic alterations in the parenchyma and inflammatory reaction in the portal tracts.

Ascorbic Acid↗
PubMed1984

[Hepatitis B viral markers in the liver tissue of HBs-antigen carriers].

It is established that the liver tissue of HBs antigen carriers, apart from the persistence of two hepatitis B virus antigens, contains morphological alterations ranging from the benign hyperbilirubinemia to the minimal and chronic persisting hepatitis. The authors claim that the minimal structural liver alterations in these patients are due to the tolerance of the immunocompetent system and deficiency of the macrophageal function of star-like endotheliocytes.

Adult↗