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G K Schlenska

Publications and source records attributed to G K Schlenska.

5 recordsLinked to original sources

[Symptomatology, diagnosis, and treatment of nervous tissue affecting toxoplasmosis in adult (author's transl)].

The neurological manifestations of three adult cases with acquired toxoplasmosis appearing like a focal lesion, multiple sclerosis and with symptoms indicating a cerebellar lesion are reported. The discussion with respect to the literature shows the following results: 1. The diagnosis of mono- and oligosymptomatic toxoplasmosis with neurological symptoms is only approximate after the introduction of the indirect immunofluorescence test too. 2. The toxoplasmosis of the nervous system in the adult is not characterized by a special syndrome like the connatale form. In contrary, it often is mimicking many well known neurological or psychiatric syndromes. 3. There may be an exacerbation of a latent infection in cause of immunosuppressive therapy or radiation of malignancy or after transplantations. 4. Treatment with the combination of pyrimethamine and sulfonamids today is handled less in spite of the possible complications and of doubtful serological results, because an early diagnosis and onset of treatment is important for a good restitution.

Adult

The symptomatology, morphology and biochemistry of glycogenosis type II (Pompe) in the adult.

The mild, generalized myopathy (glycogenosis type II) of a 23-year-old male, previously thought to have progressive muscular dystrophy, was studied clinically, electro-myographically, biochemically and with light- and electron microscopes. However, the history and clinical aspects, as well as the registration of high frequency discharges in the electromyogram first made the diagnosis uncertain. This kind of spontaneous activity has been found in nearly all cases reported in the literature. Light microscopic and histochemical examinations show vacular degeneration and glycogen storage in muscle fibres. With the electron microscope we found free dispersed glycogen in the cytoplasm and membrane-bound glycogen, glycogen-filled lysosomes. Biochemical measurements of the muscle enzymes, involved in the glycogen breakdown, were normal except for acid alpha-1,4-glucosidase, which was deficient. The evidence of these findings in this abortive form of glycogenosis type II is discussed and compared with the few cases found in the literature.

Adult