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Biomedical subjects

G K Zoloev

Publications and source records attributed to G K Zoloev.

At least 73 records · Page 4Linked to original sources
PubMedDate not supplied

[The effect of dalargin on the hemodynamics in acute myocardial infarct complicated by clinical death].

Cardiac output and myocardial contractility have been studied in dogs with experimental myocardial infarction complicated by 5 min clinical death. Control animals (16 dogs) were intravenously injected physiologic saline, while test animals (12 dogs) were administered leu-enkephalin analogue dalargin at a dose of 100 micrograms/kg, 20 min and 6-h after recovery. It has been established that dalargin improved basic hemodynamic parameters due to normalization of cardiac contractility, arrhythmia removal and reduction of the peripheral resistance. The data obtained make it possible to recommend dalargin for combined therapy of postresuscitation hemodynamic disturbances in acute myocardial infarction.

Animals↗
PubMedDate not supplied

[Blood cyclic nucleotide content in acute regional ischemia of the extremities].

Fifty healthy males aged from 19 to 34 years were examined. Experiments were conducted on 30 male mice weighing 200-250 g. After 10- and 20-minute ischemia of the upper limb the concentration of cAMP and cGMP in its venous blood increases in direct proportion to the duration of ischemia. Increase of the level of cyclic nucleotides (CN) in the blood does not depend on hypersecretion of catecholamines. Increase of the CN level coincides in time with increase of blood CPK. The mechanisms of changes in the blood CN level in ischemia are discussed.

Acute Disease↗
PubMedDate not supplied

[The role of the beta-adrenergic system in the function of calcium-regulating glands].

The examination of 27 patients with coronary heart disease and experiments on 42 rabbits showed that intravenous administration of beta-adrenostimulant isoprenaline enhanced the blood level of parathormone and depressed that of calcitonin whereas administration of any beta-adrenoblocker showed contrary results. The patterns of adrenergic system effects on function of the calcium-regulating glands were discussed.

Adult↗
PubMedDate not supplied

[Effect of enkephalins on various mechanisms regulating glycogen concentration in the liver].

Experiments were staged on 97 outbred albino male rats with the body mass of 180-220 g. The administration of a stable leu-enkephalin analog to the animals did not cause significant changes of the glycogen concentration in the liver but prevented its reduction in response to catecholamines and parathyroid hormone. Simultaneously enkephalin reduced the insulin concentration in the blood. Some mechanisms of the enkephalin effect on the hormonal regulation of carbohydrate metabolism are discussed.

Animals↗
PubMedDate not supplied

[Effect of enkephalins on the calcium-regulating function of the endocrine glands].

Experiments on rats have shown that administration of a synthetic analog of leuenkephalin at a dose of 100 mg/kg did not change the content of the immunoreactive parathyroid hormone in the blood plasma but removed the parathyroidin stimulating effect on the cAMP concentration in the renal tissue and AP activity in the blood. It is concluded that enkephalins do not influence the secretion and metabolism of the parathyroid hormone but block its peripheral effects and stimulate thyroid C-cell function.

Animals↗
PubMedDate not supplied

[Interrelation of the epiphysis and parathyroid glands].

Synergism between parathyroidin and epithalamin (an extract from the cattle epiphyses) with relation to phosphorus metabolism was revealed in experiments on guinea-pigs. Both drugs possessed a hypophosphatemic effect. The influence of epithalamin on calcium metabolism was mediated by changes in parathyroid function. An elevation of the parathyroid hormone in the blood was noted after the administration of epithalamin.

Animals↗
PubMedDate not supplied

[Effect of the epiphysial preparation epithalamin on the gonadotropic function of the hypophysis].

The influence of epithalamine on the blood content of immunoreactive follicle-stimulating and luteinizing hormones and prolactin was studied in 49 persons of both sexes and albino rats. It was shown that epithalamine promotes an increase in the concentration of the blood hormones if their initial level is lowered and vice versa. The normal hormone content is not changed under one epithalamine injection. The epiphysis-hypophysis relationships are discussed.

Adult↗