An early patient contact programme combining simulation and real settings.
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Education, Medical, Undergraduate↗
Biomedical subjects
G Kandiloğlu
Publications and source records attributed to G Kandiloğlu.
Primary pulmonary rhabdomyosarcoma arising within cystic adenomatoid malformation: a case report and review of the literature.
The current report describes a 13-month-old boy with primary pulmonary rhabdomyosarcoma (RMS) that originated within a congenital cystic adenomatoid malformation (CCAM). To the best of our knowledge, he is the youngest patient of all primary pulmonary RMS cases reported in the English-language literature. The tumor, localized in left upper lobe, was removed completely, and histologic examination showed embryonal subtype. Postoperative systemic chemotherapy was carried out. Recent evaluation 15 months after resection has not identified any residual or recurrent disease. Primary pulmonary RMS, although very rare in the pediatric age group, should be considered in young patients with solitary pulmonary masses and associated cystic lesions.
Cystic Adenomatoid Malformation of Lung, Congenita↗
P53 protein expression in eccrine poroma and porocarcinoma.
The role of p53 mutation has been shown in different human malignancies, including various skin cancers. In this study, we examined p53 protein expression in 25 eccrine poromas and 11 porocarcinomas by immunohistochemistry. P53 expression was observed in 88% (22 of 25) of eccrine poromas and 73% (8 of 11) of porocarcinomas. In eccrine poromas, percentage of cells reactive for p53 was less than 5% (low expresser) in 6 cases, 5 to 50% (moderate expresser) in 14 and greater than 50% (high expresser) in 2 cases. In terms of intensity, 13 cases showed weak staining, 8 moderate, and 1 case showed strong reactivity. On the other hand, 2 cases of porocarcinoma were low expresser, 2 were moderate and 4 were high expresser. All of the high expressers had also strong staining. This study has demonstrated that eccrine poromas showed significant p53 expression as much as porocarcinomas and, therefore, p53 positivity cannot be accepted as a valuable parameter for malignancy. P53 gene may involve in the carcinogenetic pathway of porocarcinoma but it is likely that other oncogenes may also have a role.
Acrospiroma↗
[Cowden syndrome (multiple hamartoma syndrome). Role of the dentist in early detection].
First lesions of Cowden syndrome appear in the oral cavity and on the skin. Malignant transformation is a late, common event in thyroid and breast. The early diagnosis of Cowden disease prior to the development of internal malignancy, particularly of the breast and the thyroid gland, is very important. We emphasize that the dentist may be the first health care professional who recognizes the syndrome, and this is a crucial step in the prevention and cure of the predictable malignancy. This article presents a typical case of Cowden disease.
Adult↗
Pseudo-Kaposi's sarcoma (Mali type).
A 75-year-old man presented with lesions on his right leg and on the dorsum of the penis, which had appeared 5 years ago following long distance travel. His right leg was swollen, and there was a dark-violet-colored, slightly elevated lesion extending to the thigh and penis. Histologic examination revealed thickening of the arteriolar walls and diffuse proliferation of the vascular structures surrounding the arterioles and dissecting the dermal collagen fibers. Immunohistochemical staining for Factor VIII R-A reacted positively with arteriolar endothelium, but was negative on thin-walled vascular spaces. Femoral angiography showed multiple fine arteriovenous (A-V) shunts especially at the one-third distal lower region of the right leg.
Aged↗
Eosinophilic cystitis induced by mitomycin-C.
Eosinophilic cystitis is an unusual form of cystitis which is characterized by irritative voiding symptoms and haematuria. In the report herein two adult cases of eosinophilic cystitis treated with intravesical Mitomycin-C instillations for prophylaxis of bladder carcinoma are presented and the literature is reviewed.
Administration, Intravesical↗
Actinomycosis simulating bladder tumour.
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Actinomycosis↗
Subcutaneous granuloma annulare and IgA-IgG2 deficiency.
Subcutaneous granuloma annulare (SGA) is a benign granulomatous disease occurring in childhood, with lesions most commonly located about the elbow, knee and scalp. the etiology of SGA remains obscure. We present a typical case with SGA also showing laboratory findings of IgA and IgG2 deficiency. Histologic findings of the lesions on the scalp were characterized by multiple large foci of complete collagen degeneration with a peripheral pallsade of histiocytes; the foci of degeneration was edematous basophilic. In contrast to current literature, an abnormality in the cellular immune system was not found. However, immune defects (IgA and IgG2 deficiency) related to the humoral immune system were observed.
Biopsy↗