Biomedical subjects

G Kidd

Publications and source records attributed to G Kidd.

At least 19 recordsLinked to original sources

PubMed1996

Axons regulate the distribution of Schwann cell microtubules.

It is well established that axons regulate Schwann cell phenotype. The purpose of the present study was to determine whether axons influence the arrangement of Schwann cell microtubules (MTs). Using double-labeling immunocytochemistry and confocal microscopy, we show that MTs in undifferentiated Schwann cells are nucleated from and attached to a single MT organizing center (MTOC) that is associated with the centrosome. Physical contact with appropriate axons initiates a myelin-forming phenotype that disperses MT minus ends and induces multiple MT-nucleating sites in Schwann cell perinuclear cytoplasm. The axonal signal that initiates myelin breakdown during Wallerian degeneration induces multiple MTOCs and MT bundles in Schwann cell perinuclear cytoplasm and in cytoplasm between degenerating myelin ovoids. These results establish that axons influence Schwann cell MT distribution by regulating the location and number of MT-nucleation sites.

Animals↗

PubMed1996

Phase independence of pitch produced by narrow-band sounds.

Three listeners matched the pitch of a simple tone to that of narrow-band complex signals having different phases. The pitch matches were independent of the phases; the frequency of the simple tone approximately equaled the center of gravity of the power spectrum of each complex signal. This result is inconsistent with a model that calculates the pitch of a waveform as the average of instantaneous frequency weighted by the envelope of the waveform.

Humans↗

PubMed1995

Discriminating coherence in spectro-temporal patterns.

This study examined the ability of trained listeners to discriminate coherent components in randomly varying spectral patterns. In each observation interval, the listener was presented with a sequence of bursts of multitone complexes having a fixed number of tones (m) in each burst. In the standard interval, the frequency of each tone in every burst was chosen randomly between 200 and 5000 Hz. In the signal interval, the frequencies of n tones were repeated throughout the burst sequence while the remaining m-n tones were chosen at random. The n tones were coherent in the sense that they were perceived as "sticking together" to form a pattern. The listener's task was to discriminate which burst sequence contained the n components. The results indicated that discrimination improved with increasing n/m, with increasing number of bursts per interval, and declined as the coherent components were increasingly perturbed in frequency. Further, for a fixed value of the ratio n/m discriminability was relatively independent of m. A model incorporating multichannel filtering and an optimum decision rule was reasonably successful in accounting for the experimental results.

Adult↗

PubMed1995

Binaural advantage for sound pattern identification.

Listeners were trained to identify six patterns of eight sequentially presented 48-ms tone bursts. The variation in frequency forming the patterns was confined to a relatively narrow range around the nominal center frequency, which was either 500, 1000, or 3000 Hz, or was selected randomly on each presentation from a range of 450-3300 Hz. Detection (500 and 3000 Hz only) and identification of the six patterns masked by Gaussian noise was measured in two interaural presentation conditions: masker in-phase and signal in-phase (NoSo), and masker in-phase and signal pi rad out-of-phase (NoS pi). The differences in performance in the two interaural presentation conditions for detection and identification are referred to as "masking-level differences" (MLDs) and "identification-level differences" (IDLDs), respectively. At 500 Hz, MLDs and IDLDs were about 11-13 dB. At 3000 Hz, the MLDs and IDLDs were about 1-3 dB. For the random-center-frequency condition, the slopes of the identification-level functions were much shallower for the NoS pi condition than for the NoSo condition so the binaural advantage was large at low signal-to-noise ratios and declined as signal-to-noise ratio increased. This finding was due to the broad frequency range over which the information was distributed and the decline in the binaural advantage with increasing frequency, a conclusion consistent with that reported for the binaural advantage for speech intelligibility. A second experiment demonstrated that MLDs and IDLDs could be manipulated independently: A 500-Hz tone was added to each element of the 3000-Hz patterns. A large MLD was found--due to detection of the 500-Hz tone--while the identification-level functions were determined solely by the high-frequency information, which produced small IDLDs. Finally, the Gaussian noise masker was replaced by an informational masker comprised of eight randomly chosen eight-tone bursts played simultaneously with the signal-pattern elements which were centered at 1000 Hz. Large amounts of informational masking were found for identification. The slopes of the identification-level functions were much shallower than found for the Gaussian noise masker and a relatively small binaural advantage (about 5 dB) was observed.

Adult↗

PubMed1994

Improving the detectability of a brief tone in noise using forward and backward masker fringes: monotic and dichotic presentations.

A brief tonal signal simultaneously masked by a brief noise burst became easier to hear when the masker duration was increased. The signal was a 1000-Hz tone, 4 ms in duration; the masker was a wideband noise having a spectral notch 1400 Hz wide centered at 1000 Hz. Compared to performance with a 22-ms burst masker, average detection threshold across five subjects improved by 15 dB when a 150-ms masker "fringe" preceded the signal (forward fringe), and by 9 dB when the masker fringe followed the signal (backward fringe). Little improvement was observed in either condition when the fringe was presented to the ear contralateral to the signal/burst complex. However, when the fringe was presented to both ears and the signal/burst complex to just one ear, the forward fringe was about as helpful as when the stimuli were presented monotically, but the benefit of the backward fringe was substantially reduced. The backward-fringe advantage was restored by reducing the level, or delaying the onset, of the contralateral component of the fringe. The results suggest that the forward-fringe advantage is a robust phenomenon that is largely insensitive to input to the contralateral ear. In contrast, the backward-fringe advantage appears to be a fragile effect that can be affected by inputs from both ears.

Acoustic Stimulation↗

PubMed1994

Reducing informational masking by sound segregation.

Informational masking was reduced using three stimulus presentation schemes that were intended to perceptually segregate the signal from the masker. The maskers were sets of sinusoids chosen randomly in frequency and intensity on each stimulus interval or, in some conditions, on every masker burst in a series of bursts within intervals. Masker components were excluded from the frequency region surrounding the 1000-Hz signal to minimize the energetic masking. Masked thresholds as great as 60-70 dB above quiet threshold were observed for some subjects in some conditions. It was shown that this informational masking could be reduced as much as 40 dB by: (1) presenting the masker to both ears and signal to one ear; (2) playing different masker samples sequentially in each interval of every trial; or (3) presenting the signal in alternate bursts of multiple, identical masker samples. For the binaural manipulation, informational masking was reduced because the masker and signal were perceived as originating from different interaural locations. In the latter two manipulations, a difference in the spectral or temporal pattern of the signal and masker provided the detection cue. These effects were interpreted as evidence of the importance of perceptual segregation of sounds in noisy listening environments where signal reception is not limited by energetic masking.

Acoustic Stimulation↗

PubMed1993

Auditory detection of the human brainstem auditory evoked response.

The human brainstem auditory evoked response (BAER) is a far-field electrical potential recorded from the scalp in response to transient acoustic stimuli. Typically, voltage measurements are obtained for a period of about 10 msec following the acoustic stimulus, which is repeated and summed several hundred or thousand times to permit extraction of the response from ongoing nonauditory neural activity. The judgment about whether a response has been obtained is normally based on the pattern observed in a visual display of the waveform. In this study, we investigated whether listeners can distinguish BAERs elicited by acoustic clicks from control waveforms obtained with no acoustic stimulus when the waveforms were presented auditorily. For this purpose, BAER and control waveforms were transduced by an earphone and used in an auditory detection task. Several presentation strategies were examined, including lengthening the waveform by playing it at a lower sampling rate, playing the waveform repetitively, and using the waveform to frequency modulate a pure-tone carrier. The results indicated that the BAER, when extended in duration and used to frequency modulate a 1000-Hz pure tone, was highly detectable in a YES-NO paradigm for BAERs elicited with high-level (e.g., 70 dB re. behavioral detection threshold) acoustic clicks. Performance declined to near chance as the level of the BAER-eliciting stimulus was lowered to 10 dB. In general, detection performance for stimuli presented visually was slightly, but consistently, superior to that which occurred for stimuli presented auditorily.

Acoustic Stimulation↗

PubMed1993

Individual differences in the improvement in spectral shape discrimination due to increasing number of nonsignal tones.

The effect of the number of nonsignal tones on the just-discriminable difference in spectral shape was evaluated for 12 naive subjects. The signal was an intensity increment to the center tone of a multitone complex. The tones were spaced at equal frequency ratios and, except for the signal increment, were equal in level. The number of nonsignal tones ranged from 2 to 20. Consistent with previous studies using equally spaced components, group mean thresholds improved monotonically with increasing number of tones. Group mean thresholds improved about 8 dB over the range of reference spectra employed. Large differences were found across subjects in overall performance, and in the magnitude of the improvement with increasing number of nonsignal tones. The greatest intersubject variability was observed for the stimuli composed of the fewest components. It was concluded that the differences reported in the literature concerning the presence and magnitude of the improvement are due both to differences in the procedures used and to the large individual differences that occur among subjects.

Acoustic Stimulation↗

PubMed1993

Discriminability of narrow-band sounds in the absence of level cues.

Several experiments are described in which the task of the observer was to detect an intensity increment to the center tone of a narrow-band, multitone complex. The sound-pressure levels of the stimuli were equated, then randomized, so that listeners could not detect the signal by using level cues. The primary experimental variables were the number of tones in the masker spectrum, the level of the center tone or "pedestal" relative to the other tones, the center frequency and the sound-pressure level. Both "random-phase" and "fixed-phase" conditions (referring to whether the pattern of starting phases of the nonsignal tones was chosen randomly on every presentation or was held constant throughout each trial and block of trials) were tested. Although no simple detection strategy appeared to account for all of the results, the most plausible explanation for performance in most conditions was that the listeners were able to discriminate between sounds based on subtle differences in the amplitude envelopes of the waveforms.

Adult↗

PubMed1993

A composite randomization procedure for measuring spectral shape discrimination.

In studies of auditory profile analysis [D. M. Green, Profile Analysis: Auditory Intensity Discrimination (Oxford U. P., New York, 1988)], the sounds are presented at random levels to discourage the listener from basing the discrimination on a difference in absolute level rather than on a difference in the shape of the spectrum. A difference in absolute level, however, can still provide an effective discrimination cue if the difference is comparable to the range of randomization. Using enormous ranges of random levels is not desirable, because it is distracting to normal listeners and may exceed the dynamic range of hearing for listeners with hearing loss. This article describes a new experimental procedure which permits the experimenter to greatly reduce the range of level randomization in roving-level tasks.

Acoustic Stimulation↗

PubMed1992

A new technique for measuring spectral shape discrimination.

A new technique is described for studying the ability of listeners to discriminate between sounds on the basis of spectral shape, a process called "auditory profile analysis." The advantage of the technique is that it reduces the range of the random rove in level necessary to provide a specified limit on the performance which listeners could achieve by "level detection;" that is, by employing a detection strategy based solely on comparisons of stimulus level. Thresholds were measured for the just-discriminable "ripple" (a pattern of alternating intensity increments and decrements) in an equal-amplitude, multitone reference spectrum for a group of normal-hearing listeners. Broadband, high-pass and low-pass filtered conditions were tested. The results indicated that the thresholds obtained using the new technique were well below the lowest level achievable by level detection (referred to as the "level-detection limit") in all conditions using a 20-dB random within-trial rove in overall level. The lowest threshold occurred for the broadband stimulus while the highest threshold was observed for the most extreme high-pass filtered condition. The new technique appears to be well-suited for study of profile analysis in hearing-impaired listeners where stimulus bandwidth and rove range are limited.

Acoustic Stimulation↗

PubMed1991

Evaluation of simple models of auditory profile analysis using random reference spectra.

This article describes further study of the finding reported by Green et al. [J. Acoust. Soc. Am. 73, 639-643 (1983)] and others that, in certain conditions, the threshold of detectability for an intensity increment to the center tone of a multitone reference spectrum decreased as the number of nonsignal tones increased. That result was considered remarkable since critical-band theory would predict that these nonsignal tones, spaced outside the "critical band" containing the signal, would have no effect on or, at most, slightly decrease within-band detectability--and certainly could not account for the result of improved detectability found in the study cited above. Recently, Henn and Turner [J. Acoust. Soc. Am. 88, 126-131 (1990)] were unable to replicate the result described above, concluding that the phenomenon exists only in "limited conditions" and that is "highly individual" in nature. Further, they speculated that the most likely reason for the discrepancy between their study and previous studies was the selection and/or training of the observers. The present study addressed the effects of the amount of subject training on the finding of Green et al. while controlling the potential effects of stimulus order. Specifically, for a group of three "naive" listeners, thresholds were measured for 3-, 7-, and 21-tone inharmonic complexes as a function of the amount of practice in a mixed-block design. In all cases the group mean thresholds decreased as the number of nonsignal tones increased both initially and after extensive practice for both fixed- and roving-level conditions. Thus the effect does not appear to be an artifact of the amount or order of training subjects receive. The possible role of subject sample size and the magnitude of individual differences in obtaining the effect remains an open question. Two hypotheses suggested to account for the improvement in threshold with increasing number of nonsignal tones were evaluated. The hypotheses were represented by simple mathematical models, referred to as the "multiple-comparison" and "pitch-cue" models. The predictions of both models were compared with the results of a series of detection experiments in which the independent variables were the number of nonsignal tones and amount of random, within-trial "amplitude perturbation" [cf. Kidd et al., J. Acoust. Soc. Am. 79, 1045-1053 (1986)] of the nonsignal tones. Neither model, as applied, provided a satisfactory account of the effects of the main variables of number of tones and amount of perturbation.(ABSTRACT TRUNCATED AT 400 WORDS)

Adult↗

PubMed1990

The effects of nedocromil sodium on the response to grain dust in West Australian grain workers.

Seasonal grain workers in Western Australia who develop respiratory symptoms after exposure to grain dust develop concomitant changes in lung function and bronchial responsiveness to methacholine. The mechanisms underlying these changes are not known. A detailed study was undertaken of seasonal grain workers in Western Australia to evaluate the effect of nedocromil sodium (Fisons, United Kingdom) on these changes to see if they could be prevented by this drug. Forty seven subjects participated. Symptoms and forced expiratory volume in one second (FEV1) were recorded before the study and before, during, and after each working shift, and bronchial responsiveness to methacholine was measured at the beginning and end of the study. Twenty three subjects received nedocromil and 22 received a placebo in a double blind design; there was no difference in baseline characteristics between the two groups. At the end of the study, no differences were found between the nedocromil and placebo groups in the prevalence of symptoms or development of new symptoms during the study. The drug had no effect on changes in methacholine PD20 or FEV1. As in previous studies, new symptoms developing during the season were more common in atopic subjects and were associated with a fall in methacholine PD20. It is concluded that nedocromil has no effect on the development of new symptoms in grain workers. The mechanisms underlying these symptoms require further study.

Adolescent↗

PubMed1989

Roving-level tone-in-noise detection.

The detectability of tones, or of intensity increments to tones, in bands of random noise was measured for conditions in which the overall level was fixed or was randomly roved from interval to interval of every experimental trial. The purpose of the within-trial rove was to limit the usefulness of a detection strategy based on overall level or level within a single "critical band." At "supracritical" bandwidths, the functions relating masked threshold to noise bandwidth for the roved conditions were similar to those obtained when no rove was employed. At "subcritical" bandwidths, thresholds were higher in some roved conditions, but, for the largest rove, were still lower than would be predicted from arguments based purely on level detection--with one exception. A comparison of observer performance relative to the statistical limits imposed by the roving-level procedure indicated that the traditional critical-band energy-detector model could not account for the results, which are attributed to discrimination based on spectral shape or on waveshape.

Adult↗

PubMed1988

Evidence for sensory-trace comparisons in spectral shape discrimination.

The ability of experienced observers to discriminate changes in the shapes of complex sound spectra was studied for three conditions. In one condition, the reference spectrum or "background" was fixed in spectral shape across each block of trials; in a second condition, the reference spectrum differed in spectral shape from trial to trial within each block of trials but was the same for the two presentations within a trial; and, in a third condition, the reference spectrum differed in spectral shape on every stimulus presentation. The variation in the reference spectrum was a random perturbation in the amplitudes of the tonal components comprising the complex sounds. The signal was an intensity increment to the center component (1000 Hz) of the complex and was present in one interval of each two-interval, two-alternative, forced-choice trial. The principal experimental manipulations were the degree of amplitude perturbation of the reference spectrum and the interval of time between the two stimulus presentations of each trial (interstimulus interval, ISI). The theory proposed by Durlach and Braida [J. Acoust. Soc. Am. 46, 372-383 (1969)] describing memory processes involved in the perception of sound intensity was used to explain the experimental results. As that theory was applied in this study, only the condition in which the stimuli were perturbed between trials showed evidence for comparisons based on "sensory traces," while the conditions in which the stimuli were fixed or were perturbed within trials were best explained by comparisons based on judgments relative to the stimulus context.

Acoustic Stimulation↗

PubMed1987

Calibration of ear canals for audiometry at high frequencies.

A procedure is described for determining the absolute sound pressure at the inner end of the ear canal when a sound source is coupled to the ear, for frequencies in the range 8-20 kHz. The transducer that generates the sound is coupled to the ear canal through a lossy tube, yielding a source impedance that is approximately matched to the characteristic impedance of the ear canal. A small microphone is located in the coupling tube close to the entrance to the ear canal. Calibration is carried out by measuring the response at this microphone when an impulse is applied at the transducer. To estimate the sound pressure at the medial end of the ear canal, the Fourier transform of this impulse response is corrected by an all-pole function in which the poles are estimated from the minima in this Fourier transform. Data on individual ear canals are presented in terms of gain functions relating the sound pressure at the medial end of the ear canal to the sound pressure when the coupling tube is blocked. The average gain function for a group of adult ears increases from 2 to 12 dB over the frequency range 8-20 kHz, in rough agreement with data from ear-canal models. Possible sources of error in the calibration procedure are discussed.

Acoustics↗

PubMed1987

High-frequency audiometric assessment of a young adult population.

The hearing thresholds of 37 young adults (18-26 years) were measured at 13 frequencies (8, 9,10,...,20 kHz) using a newly developed high-frequency audiometer. All subjects were screened at 15 dB HL at the low audiometric frequencies, had tympanometry within normal limits, and had no history of significant hearing problems. The audiometer delivers sound from a driver unit to the ear canal through a lossy tube and earpiece providing a source impedance essentially equal to the characteristic impedance of the tube. A small microphone located within the earpiece is used to measure the response of the ear canal when an impulse is applied at the driver unit. From this response, a gain function is calculated relating the equivalent sound-pressure level of the source to the SPL at the medial end of the ear canal. For the subjects tested, this gain function showed a gradual increase from 2 to 12 dB over the frequency range. The standard deviation of the gain function was about 2.5 dB across subjects in the lower frequency region (8-14 kHz) and about 4 dB at the higher frequencies. Cross modes and poor fit of the earpiece to the ear canal prevented accurate calibration for some subjects at the highest frequencies. The average SPL at threshold was 23 dB at 8 kHz, 30 dB at 12 kHz, and 87 dB at 18 kHz. Despite the homogeneous nature of the sample, the younger subjects in the sample had reliably better thresholds than the older subjects. Repeated measurements of threshold over an interval as long as 1 month showed a standard deviation of 2.5 dB at the lower frequencies (8-14 kHz) and 4.5 dB at the higher frequencies.

Adolescent↗

PubMed1986

Auditory profile analysis of irregular sound spectra.

The discrimination of changes in the shapes of sound spectra is reported. The change was always an intensity increment to the 948-Hz component of a multitone complex. First, the ability of naive listeners to learn to discriminate a change in a "regular" background or reference spectrum (equal-level tones equally spaced in logarithmic frequency) was measured as a function of the number of trials. On the average, threshold improved about 10 dB over 3000 trials, with about 50% of the decrease in threshold occurring during the first 750 trials. In a subsequent series of experiments, the overall pattern of spectral shape of the background was varied randomly. Two kinds of perturbations in spectral shape were employed: Randomly choosing the frequencies of the reference spectra and randomly choosing the amplitudes of the components of the reference spectra. The experimental manipulations involved fixing the random spectra across a block of trials, varying the reference spectra from interval to interval of each trial, and providing extensive practice in discriminating specific randomly perturbed reference spectra. The results of the spectrum-learning and random perturbation experiments provide insight into the roles of critical band filtering, sensory variability, and short-term and long-term memory representations in auditory profile analysis. Further, the appropriateness of the generalization of a simple energy detection model is discussed.

Acoustic Stimulation↗