Biomedical subjects

G Kierfeld

Publications and source records attributed to G Kierfeld.

At least 19 recordsLinked to original sources

PubMed1997

[Clinical relevance of acetylator phenotyping in 196 urothelial tumor patients].

A total of 196 patients with urothelial tumours were phenotyped for N-acetyltransferase 2 by the molar ratio of two caffeine metabolites excreted in urine. The proportion of "slow" acetylators, who are genetically predisposed to urothelial tumours if they have been exposed to aromatic amines in the past, in the entire group was 55%, within the range in a normal population. Among 40 patients with assumed former occupational exposure to aromatic amines, 65% were "slow" acetylators. Invasiveness, histopathological grading of the urothelial tumour at the time of first diagnosis, and course were not related to acetylator phenotype.

Acetylation↗

PubMed1996

Occupational history and genetic N-acetyltransferase polymorphism in urothelial cancer patients of Leverkusen, Germany.

OBJECTIVES: The study was designed to realize possible shifts in the ratio of slow to fast acetylators within a group of 196 urothelial cancer patients in an area with earlier benzidine production. METHODS: The subjects were interviewed for occupational and nonoccupational risk factors. The patients were phenotyped for N-acetyltransferase 2 (NAT2) by Grant's caffeine test. A subgroup of 54 patients was additionally genotyped for NAT2. RESULTS: The antimode in the NAT2 phenotyping with the caffeine test (AFMU: IX ratio) was 1.0, as evidenced by additional genotyping of the subgroup of 54 patients. The prevalence of slow acetylators in the entire group of bladder cancer patients was 55%, in accordance with published figures for European populations. In a subgroup of 40 patients with occupational histories as workers in chemical or rubber industries 65% were slow acetylators. In a further subgroup of 28 cases having specifically worked at chemical production sites of the local chemical industry, 68% were slow acetylators. CONCLUSIONS: In contrast to earlier studies, this study shows no increased prevalence of slow acetylators among urothelial cancer patients in comparison with the normal population. However, in subgroups of cases with a likelihood of past occupational contacts with aromatic amines, there was a trend towards a higher representation of slow acetylators. This finding is in accordance with observations of others that the percentage of slow acetylators in urothelial cancer patients is generally decreasing, possibly because the production of benzidine and benzidine-based dyes ceased in the early 1970s.

Acetylation↗

PubMed1994

[Urothelial diseases as an occupational disease].

The number of urothelial tumors of the lower urinary tract caused by occupational exposure is expected to markedly exceed the number of diseases which are actually compensated. The German compensation system for diseases is explained using the example of disease number 1301 which applies to bladder diseases due to aromatic amines. A standard procedure for the evaluation of the percentage of disability ("MdE") caused by tumors of the urinary bladder is presented. Important working areas which are associated with an elevated tumor risk of the lower urinary tract are mentioned. Cancerogenic aromatic amines can also be liberated in the human organism from soluble, i. e. bioavailable, azo dyes by reductive cleavage. Therefore, as a first step, a detailed work history (starting from the beginning of apprenticeship) must be obtained in all cases of urothelial tumors because of the very long latency time of tumors of the urothelium which can be up to fourty years and higher.

Carcinoma, Transitional Cell↗

PubMed1988

[Results of single-stage repair of distal hypospadias using the King modification].

From 1975 to 1986 34 patients undergoing repair of distal hypospadias between the age of 2 and 11 were explored. Standard method of the one-stage correction of distal hypospadias without or with moderate chordee was the operative technique according to the modification of King. After rolling the urethral groove into a tube the neourethra is covered with an asymmetrical part of dorsal hood. Thus the operative aims such as nonproblematic micturition, normal cohabitation and ejaculation and a good cosmetic result, avoiding psychological problems, can be obtained. The total complication rate was 23.4%; the correction of urethral fistulas in two layers as ambulatory operations was nonproblematic. By using Silastic foam the incidence of postoperative edema could be reduced significantly.

Bandages↗

PubMed1988

[Revascularization of the penis in vascular-induced erectile dysfunction: clinical results of the Hauri surgical method].

Hauri's modification of the procedure for operative penile revascularization has been known since 1983; it is characterized by an anastomosis between the inferior epigastric artery and the dorsal artery of the penis with an arteriovenous shunt with the deep dorsal vein of the penis. Since 1986 this surgical technique has been applied in 18 patients with vascular erectile dysfunction. Their average age was 47 years, and the mean observation period was 8 months. We did not consider the operation indicated unless the presence of pathologic vessels was demonstrated in the distal region of the internal pudendal artery by selective arteriography. After the operation, a 6-month therapy with platelet aggregation inhibitors is necessary. At postoperative follow-up 12 of the 18 patients reported that their sex life was unrestricted and they had spontaneous erections.

Adult↗

PubMed1984

[Value of exfoliative cytology of the urinary bladder in occult bladder cancer and in the control of treated cancers].

The exfoliative cytology of the urinary bladder is helpful in the detection of occult bladder carcinoma, which in according to definition is not recognizable without magnification, as well as in the follow-up of treated bladder carcinoma. Within a period of 5 years 23 occult bladder carcinomas were detected by cytological studies alone. The degree of malignancy of the established transitional cell carcinoma varied between G2 and G3. The latent period between the found cytological result and the histological confirmation amounted to 14 months. In our experience the diagnosis of occult bladder carcinoma can be established by exfoliative cytology of the urinary bladder, if invisible parts of tumor with moderate and high degree of malignancy communicate with the mucosa of the bladder. The cytological recognition of malignant cells of urothelium offers valuable support for further therapeutic procedures, if there is no cystoscopic evidence of tumor in the bladder. In addition to clinical diagnosis of bladder cancer exfoliative cytology of the urinary bladder should also be part of the follow-up of treated bladder cancer.

Biopsy↗

PubMed1975

[Urinary diversion through isolated bowel segments (author's transl)].

80 cases of urinary diversions by means of an ileal or colon conduit are reported. Indications and the operative technique with several variations especially of the bowel-ureter-anastomosis are described. The significance of intestino-uretero-renal reflux and the role of urinary infection in different compartements of the isolated segment are discussed: if the stoma is large enough no reflux can be observed; in the majority of cases infection is limited to the distal part of the segment. Urinary diversion by isolated bowel segments seems to be a safe procedure especially for the protection of the upper urinary tract, preferable to diversion into the non-isolated colon.

Bladder Exstrophy↗

PubMed1975