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Biomedical subjects

G Kiosseoglou

Publications and source records attributed to G Kiosseoglou.

14 recordsLinked to original sources
PubMed2002

Differences in language performance in variations of lateralization.

Language proficiency was studied in 489 primary-school-aged children classified as extreme left-, extreme right-, mild left-, and mild right-handers on the basis of both hand-preference and hand-skill, using a test battery of seven measures. An ANOVA run on factor scores showed neither significant association of language proficiency with variations of lateralization regarding hand-preference and hand-skill nor differences in factor structure derived from a principal component analysis between extreme vs. mild hand-preference and hand-skill groups. Moreover, low language proficiency was not significantly associated with specific patterns of lateralization in hand-preference subgroups. In contrast, low language performers with poor hand-skill were significantly overrepresented both in the extreme left-handed group alone and when combined with the extreme right-handed, in comparison to mild left- and mild right-handed with respect to population. The data are not consistently accommodated by the theory of balanced polymorphism (mainly Annett, 1978, 1985 Annett & Manning, 1989 ). Alternately, factors such as lag of maturation ( Bishop, 1980, 1984, 1990a, 1990b ), delay of growth ( Geschwind & Galaburda, 1985b ), and developmental instability associated with unique patterns of variations in lateralization ( Yeo, Gangestad, & Daniel, 1993 ) are discussed as possible factors accounting for the present results.

Brain↗
PubMed2001

Quality of life in Parkinson's disease: Greek translation and validation of the Parkinson's disease questionnaire (PDQ-39).

The Parkinson's disease questionnaire (PDQ-39) is a well-validated British scale for the assessment of health-related quality of life (HQoL) in Parkinson's disease (PD). The PDQ-39 has been translated into Greek and it was applied to 119 Greek PD patients. These patients were classified in stages according to the Hoehn and Yahr (HY) scale and their motor disability was assessed by means of the Unified Parkinson's disease rating scale (UPDRS) as well as the Schwab and England activities of daily living scale (ADL). The Beck depression inventory (BDI) was applied for the evaluation of depression. The translated version of PDQ-39, designated PDQ-39GrV, was validated as follows: (1) Cronbach's alpha coefficient and item-total Spearman's rank-order correlations were calculated in order to estimate the internal consistency of PDQ-39GrV scales. (2) Validity of the PDQ-39GrV was examined in terms of agreement with the clinical assessment parameters (stage, UPDRS. ADL and BDI scores). (3) Sixty one PD patients were re-evaluated 3-7 days later in order to check test-retest reliability. The results showed the following: (1) The PDQ-39GrV demonstrated very good internal consistency (alpha 0.71-0.94). Item-total correlations were statistically significant (r: 0.52-0.93). Test-retest measurements correlated significantly (p = 0.001). (2) Clinically obtained motor parameters correlated well with PDQ-39GrV scales influenced by physical aspects of the disease, while emotionally and socially influenced ones correlated with depression. Our findings indicate that PDQ-39 GrV is a reliable, easy to administer scale for the assessment of HQoL in Greek PD patients.

Activities of Daily Living↗
PubMed2001

Concurrent validity of the Test of Nonverbal Intelligence in Parkinson's disease patients.

The Test of Nonverbal Intelligence (TONI-2; L. Brown, R. J. Sherbenou, & S. Johnsen, 1990) and Raven's Colored Progressive Matrices (RCPM; J. C. Raven, 1965) are defined as language-free measures of cognitive ability. The purpose of the present study was to investigate the relation between the RCPM and the TONI-2 for samples of patients with Parkinson's disease (n = 75) and controls (n = 47). A regression equation was computed to evaluate the relation of the RCPM scores to the TONI-2 quotient. Regression equation results indicate that there is a significant overlapping linear variance between the two measures in both patients and controls.

Aged↗
PubMed2000

Abnormality of N30 somatosensory evoked potentials in Parkinson's disease: a multidisciplinary approach.

PURPOSE OF THE STUDY: Assess the N30 component of median nerve somatosensory evoked potentials (SEPs) in patients with Parkinson's disease (PD) and correlate its parameters with the severity of the disease, general cognitive ability and regional cerebral blood flow (rCBF). PATIENTS AND METHODS: Twenty-three non-demented, non-depressed PD patients (at stage II and III of the disease) and 23 age- and education-matched normal controls were enrolled in the study. SEPs were elicited by median nerve stimulation. PD patients' cognitive ability was assessed by means of: 1) Raven's Colored Progressive Matrices (RCPM); 2) the Test of Non-Verbal Intelligence (TONI-2); and 3) the Wisconsin Card Sorting Test (WCST). The patients' rCBF was evaluated by HMPAO SPECT. RESULTS: There was no difference between SEP N30 latency in PD patients and controls (P > 0.05). The P20-N30 peak-to-peak amplitude was lower in PD patients bilaterally (P < 0.05), and the amplitude of N30-P40 was lower on the right side only (P < 0.05). A significant increase in the amplitude ratio P14-N20/P20-N30 was observed in PD patients (P < 0.05). The correlation of these findings with the clinical parameters of the disease, and notably motor signs, was not significant. Of the three neuropsychological tests only the RCPM showed a positive relation to right P20-N30 amplitude. Regression analysis between SEP parameters and rCBF showed a correlation of N30 amplitude with blood flow in parietal cortical areas, but not in frontal regions.

Aged↗
PubMed2000

The relationship of parental attachment and psychological separation to the psychological functioning of young adults.

The authors explored the interrelations between attachment patterns and psychological separation from parents as well as the contribution of these variables to adaptive psychological functioning. Among 153 university students in Greece, there was a positive association between security of attachment and freedom from guilt, anxiety, and resentment toward one's parents (conflictual independence); in contrast, there was an inverse relation between security of attachment and independence from parents in relation to emotional, functional, and attitudinal independence. Compared with the insecurely attached students, the securely attached students also scored higher on measures of self-esteem and lower on measures of anxiety and loneliness.

Adaptation, Psychological↗
PubMed1999

Wisconsin Card Sorting Test variables in relation to motor symptoms in Parkinson's disease.

The Wisconsin Card Sorting Test, a standard test for the assessment of executive function and free of a motor component, was employed for the assessment of 37 nondemented patients with idiopathic Parkinson's Disease and 37 matched normal controls. The symptoms of the patients were clinically assessed by means of the Unified Parkinson's Disease Rating Scale, which yielded scores for the cardinal symptoms of the disease as well as a total motor score. The Wisconsin Card Sorting Test was administered in all subjects in its original form (128 cards), and it was scored to yield 16 measures according to the instruction of the Wisconsin Card Sorting Test revised manual. Patients with Parkinson's Disease had significantly lower scores on the following test variables: number of trials administered, perseverative responses, percent perseverative responses, and failure to maintain set. The correlations between the last three variables and total motor score were statistically significant. Of the four cardinal symptoms of the disease, only rigidity correlated significantly with the number of perseverative responses and percent perseverative responses. These findings provide a clue that the lower performance of these patients on certain variables of the Wisconsin Card Sorting Test may be related to the process of the disease.

Female↗
PubMed1998

Do the hands talk on mind's behalf? Differences in language ability between left- and right-handed children.

Two hundred seventy children of school age, 135 of whom were left-handed and an equivalent number of whom were right-handed, have been examined in the present study using a test battery of nine language ability measures: Vocabulary, Similarities, Comprehension (WISC-R), Deductive Reasoning, Inductive Reasoning, Sentence Completion, Comprehension of Sentential Semantics, Comprehension of Syntax, and Text Processing. The data analysis has indicated that: (1) One-factor solution applies both to the right- and left-handed population according to Standard Error Scree Method (Zoski & Jurs, 1996) with regard to language ability measures. (2) Handedness discriminates between right-handers (superior) and left-handers (inferior) in language ability. (3) There have been subgroups of left-handed children who differ in language ability distribution compared with right-handed children according to Hierarchical Cluster Analysis. (4) Extreme versus mild bias to hand preference and hand skill do not differentiate performance subgroups neither within the left-handed nor within the right-handed main group. (5) Sex and familial sinistrality do not affect performance. The results are discussed in relation to (a) "human balanced polymorphism" theory advocated by Annett (mainly Annett, 1985, 1993a; Annett & Manning, 1989), (b) potential pathology (mainly Bishop, 1984, 1990a; Coren & Halpern, 1991; Satz, Orsini, Saslow & Henry, 1985) and "developmental instability" (Yeo, Gangestad & Daniel, 1993), and delay of left-hemisphere maturation in left-handed individuals (Geschwind & Galaburda, 1985a,b, 1987), by pointing out the strength and weaknesses of these theoretical approaches in accounting for the present data.

Brain↗
PubMed1998

A longitudinal study of visuospatial discrimination in parkinsonian patients.

Visuospatial discrimination was evaluated longitudinally in 45 patients with idiopathic Parkinson's disease. 47 normal matched subjects served as controls. Visuospatial discrimination was assessed by means of a picture test with complex superimposed objects (Poppelreuter's test) at the beginning of the study as well as three years later. At initial evaluation the group with Parkinson's disease identified fewer objects than the control group and made more errors. Relations between performance on the visuospatial discrimination task and the main parameters of the disease were not statistically significant. At reevaluation, three years later on the same task, performance by the group with Parkinson's disease deteriorated. Longitudinal assessment of motor symptoms showed that disease progressed during the study period in 35 patients. Comparison of motor deterioration with performance on the visuospatial discrimination task showed no statistically significant relationship.

Cognition Disorders↗
PubMed1997

Effects of cognitive ability and affect on school mathematics performance and feelings of difficulty.

Research on cognitive ability and affect has indicated that both of them may function at various levels of generality (LG). This study aimed to investigate the possible effects of LG on school mathematics performance and related feelings of difficulty. Two hundred forty-three students of seventh, eighth, and ninth grades of both genders participated in the study. They were tested with cognitive ability tasks, affective questionnaires, and two school mathematics batteries. The difficulty of each of the school mathematics task was also rated on a 4-point scale. The two school mathematics batteries and affective questionnaires were re-administered 1 year after the first testing. Rates of difficulty were also taken. Path analysis showed that performance was mainly influenced by cognitive ability factors, whereas feelings of difficulty were influenced by performance, cognitive ability, and affective factors. The long-term relations between cognitive and affective factors are discussed.

Adolescent↗
PubMed1992

Handedness and spatial ability in children: further support for Geschwind's hypothesis of "pathology of superiority" and for Annett's theory of intelligence.

Spatial ability of 60 left-handed and 60 right-handed school children was investigated using a battery of nine tasks. The results do not agree with Levy's (1969, 1976) theory predicting spatial inferiority of left-handed individuals. Instead, higher performance by left-handed children provided further support for Annett's (Annett & Manning, 1989) theory on intelligence and for Geschwind's (Geschwind & Galaburda, 1985) hypothesis of "pathology of superiority." The distinction of left-handed and right-handed individuals into familial and nonfamilial groups appeared to be psychologically equivocal according to our results.

Aptitude↗
PubMedDate not supplied

Correlations between the Functional-Cognitive Assessment Scale and the Alzheimer's Disease Assessment Scale when administered to patients with dementia residing in long-term care.

The Alzheimer Disease Assessment Scale (ADAS) and the Functional Cognitive Assessment Scale (FUCAS) examine the cognitive performance of patients with dementia. ADAS has been widely used as a clinical instrument, mainly in clinical trials. FUCAS is a useful tool in diagnosing early dementia since it examines executive skills. Moreover, it is sensitive to the subtle changes that occur during the progress of the disease. The aim of this study was to examine the possible correlations between FUCAS and ADAS. The 2 neuropsychological scales were administered to 32 patients with dementia residing in long-term care. They were 12 men and 20 women, 65 to 90 years old, with 4 to 12 years of education. Twenty-four patients were reassessed 3 months after the first assessment, with the same scales. Pearson's correlation showed that the total score of FUCAS correlated significantly with the total score of ADAS: r = 0.80 (P < .01). The t test showed that changes over the 3 months for FUCAS were more significant than ADAS, suggesting that FUCAS is a more sensitive tool.

Aged↗
PubMedDate not supplied

Superoxide dismutase activity in early and advanced Parkinson's disease.

Superoxide dismutase (SOD) is an enzyme system that is implicated in the oxidant stress model of Parkinson's disease (PD) pathogenesis. This study was designed to assess SOD activity in whole blood and red blood cells of PD patients in early and advanced stages of the disease. Fifteen PD patients in stage I and II (group A) and 15 in stage III and IV (group B) as well as 15 normal controls were included in the study. SOD activity was assessed in whole blood and red blood cells. Group B patients showed a statistically significant decrease of SOD activity in whole blood and in red blood cells. A negative correlation between SOD activity and duration of the disease was observed, while there was no relationship between L-Dopa treatment and SOD activity. Our results indicate that a defect in SOD activity develops over time in PD. Whether this is a later manifestation of antioxidant mechanism deterioration or simply an epiphenomenon remains unclear.

Aged↗