Biomedical subjects

G Kissinger

Publications and source records attributed to G Kissinger.

4 recordsLinked to original sources

PubMed1990

[The technical requirements for percutaneous fine-caliber cholangioscopy. Experimental experiences with an animal model].

A total of 115 percutaneous fine-calibre cholangioscopies were performed in an animal model, using different types of fine-calibre cholangioscopes of 0.8 to 2.8 mm. diameter. Additional properties of single endoscopes included different flexibility, deflectability of the tip, occlusion balloon and working channel. Due to the low steerability of the instruments used, a coaxial guidance by an introducing sheath was mandatory for sufficient imaging quality. Besides flexibility and provision of a working channel, no other properties contributed to a successful endoscopic inspection of the biliary system.

Animals↗

PubMed1990

Fine caliber cholangioscopy.

The miniaturized diameters of endoscopes (miniendoscopes) allow percutaneous access for endoscopic visualization of the extrahepatic and intrahepatic biliary system. Practical aspects of different miniendoscopes in an experimental model are described. Clinically, fine caliber cholangioscopy is helpful in detection of retained biliary stones. Nevertheless, discrimination of benign and malignant stenosis remains difficult, and simultaneous intervention under endoscopic guidance is compromised by the low steerability of the instruments.

Animals↗

PubMed1989

Thermal laser-induced stenosis of the common bile duct. An alternative model for experimental research.

An experimental model of bile duct stenosis and occlusion in dogs is presented. After percutaneous cholecystostomy of the gallbladder, which had been affixed to the abdominal wall during laparotomy four weeks earlier, a standard 2 mm laser heat probe adapted to an Nd:YAG laser (1,064 nm) was advanced inside the proximal common bile duct in 12 animals, using 6 or 7 F sheaths. The proximal part of the common bile duct was exposed to laser pulses of 6 to 10 Watts for one second. Within 3 to 15 days, total occlusion or severe stenosis of the common bile duct consistently occurred and was verified by follow-up percutaneous cholecystocholangiography. No perforations occurred. Compared with other models, laser thermal damage is an easy and reliable method of producing bile duct stenoses for experimental purposes.

Alanine Transaminase↗

PubMedDate not supplied

Long-term patency of Wallstent endoprostheses in benign biliary obstructions: experimental results.

PURPOSE: Coated and noncoated Wallstents were implanted in dogs with experimental benign common bile duct stenoses to monitor the long-term patency of self-expanding stents in the biliary system. MATERIALS AND METHODS: Experimental common bile duct stenoses were induced with a thermal laser in 12 dogs. Three silicone-coated and 14 noncoated stents were implanted. The animals were followed up from 3 to 25 months by means of cholangiography, cholangioscopy, measurements of liver enzyme levels, autopsy, and histology. RESULTS: Silicone coated stents failed in all cases, resulting in two total occlusions and one stent dislodgment to the bowel. Noncoated stents led to marked mucosal hyperplasia and stent narrowing in most cases, but with follow-up of more than 12 months, hyperplasia underwent regression and--except in one case--neither an increase in liver enzyme levels nor stent occlusion occurred. Histologically, the extent of hyperplasia was related to the stent position within the duct wall. With stents in the mucosal layer, hyperplasia was excessive. Once the stent entered the submucosal layer, hyperplasia was decreased. CONCLUSION: In an experimental setting, mucosal hyperplasia did not compromise patency of noncoated stents in benign bile duct stenosis and regressed with late follow-up after 12 months.

Animals↗