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Biomedical subjects

G Kluxen

Publications and source records attributed to G Kluxen.

At least 19 recordsLinked to original sources
PubMed1990

[In vivo measurement of the distribution of the refractive index of the human lens using a Scheimpflug photo of the anterior eye segment and a helium-neon laser beam].

The distribution of the refractive index of the human lens in vivo is measured by taking a Scheimpflug photograph of the anterior segment while simultaneously passing a HeNe laser beam through these structures. The refractive index can be evaluated simply by using the Snellens formula for refraction on the course of the beam after reevaluating the Scheimpflug photograph for distortion. It is possible to perform this measurement during accommodation and in the relaxed lens.

Humans↗
PubMed1989

Lesion and regeneration of the anterior and posterior lens capsule and cortex in rabbits Nd:YAG laser.

With a mode-locked Nd:YAG laser set at various energy levels, anterior and posterior capsular and cortical lesions were produced in the lens of rabbits. Biomicroscopic and Scheimpflug examinations showed the anterior lesion to be healing in a whitish scar that was restricted to the area of the original lesion. Histology and transmission electron microscopy (TEM) demonstrated the proliferation of epithelial cells that produced a new, continuous, basement membrane-like capsule. In the area of the lesion collagenous material, myofibroblast-like cells and macrophages were found. Laser-induced lesions in the posterior lens capsule and lens protein resulted in damage to the capsule and grey opacity of the lenticular proteins, which remained unchanged for 6 weeks. Neither inflammatory nor epithelial cells appeared within the locally damaged lens. Macrophages migrated from the vitreous into the lesion; they were observed either in intercellular clefts or within a lens fibre, almost completely taking up their cross section.

Animals↗
PubMed1989

Fundus polaroid screening for diabetic retinopathy. Is one print per patient enough?

The CR3-45 NM Canon nonmydriatic fundus camera detects relevant diabetic retinopathy with high sensitivity. To determine whether examination of one eye per patient would suffice for screening purposes, 473 pairs of standard 45 degree fundus Polaroid prints obtained with the Canon camera were assessed from 167 patients with and 306 without diabetic retinopathy. On the basis of considering only one eye per patient, absence of retinopathy would have been diagnosed in 336 patients, with 9% of the diagnoses false negative. One hundred thirty-seven of the 167 patients with retinopathy in at least one eye would have been diagnosed correctly by considering one eye per patient (sensitivity 82%, specificity 100%). Thus, a standard 45 degree fundus Polaroid print from one eye per patient may suffice for screening purposes if the picture is free from diabetic abnormalities. Otherwise, both eyes should be examined immediately, and the patient should be referred to an expert ophthalmologist who specializes in diabetic retinopathy for confirmation of the diagnosis and staging of diabetic retinopathy status.

Adult↗
PubMed1987

[Evaluation of Scheimpflug photographs in transitory hypermetropia].

Scheimpflug photography of lenses with transient hypermetropia in cases of diabetes mellitus revealed an enlargement of the axial diameter of the cortex and especially of the nucleus of the lens. This transient hypermetropia is thought to stem from a decrease in the refractive index of the lens cortex and nucleus.

Diabetes Mellitus, Type 2↗
PubMed1987

Retinal blood vessel test in young-onset diabetic patients.

136 patients with insulin-dependent diabetes mellitus (IDDM) were shown the entoptic blood vessel figure. All patients were examined independently by retinal fluorescein angiography and ophthalmoscopy. 34 patients had no retinopathy, none of them believed to see alterations. 102 patients had different phases of diabetic retinopathy. If there were 1-5 microaneurysms within the 15 degrees meridian surrounding the central fovea, 55% of the patients were able to detect their alterations. If there were 6-20 microaneurysms, 77% of the patients were able to diagnose them. 90% of the patients with an even more severe retinopathy could see their abnormalities. Obviously there are no incorrectly positive results. For intelligent and well-observing patients with IDDM the retinal blood vessel test is a useful method for early detection and self control of diabetic retinopathy. Nevertheless, control of the fundus by an ophthalmologist is still necessary.

Adolescent↗
PubMed1985

[Retinal findings in the hereditary persistence of fetal hemoglobin and glucose-6-phosphate dehydrogenase deficiency (G-6-PD deficiency)].

Peripheral arteriolar occlusions of the retinal vessels and the 'black sunburst sign' as the first stage of sickle-cell retinopathy (Goldberg 1976) were found in a 34-year-old black patient from West Africa with hereditary persistence of fetal hemoglobin (HPFH) and glucose-6-phosphate dehydrogenase deficiency (G-6-PD-D). The patient's son was found to have HPFH without G-6-PD-D, his daughter HPFH as well as G-6-PD-D. Ophthalmoscopic findings in the two children were normal. In the mother - a white German without clinical symptoms - neither HPFH nor G-6-PD-D were found. This is the first description of the typical picture of 'sickle-cell retinopathy' in a patient with HPFH combined with G-6-PD-D. HPFH is not associated with any retinal symptoms or hematological abnormalities. Hemolytic crises induced by fava beans or drugs in G-6-PD-D alone lead to different ocular complications from those found in this patient.

Adult↗
PubMed1985

[Monocular polyopia in nuclear cataract].

Only patients with primary nuclear cataracts perceive multiplied images caused by the lens. All of them see these images in a lambda-shaped arrangement. This is not a diplopia caused by the two focal points of a 'Linse mit doppeltem Brennpunkt' (double-focus lens). The monocular polyopia can be explained by a prismatic effect of the sectors of the lens nucleus.

Cataract↗
PubMed1983

[Variability of iris fluorescence angiograms].

Fluorescein angiography of the iris vascular system is more difficult in heavily pigmented irides of the coloured races; in light skinned patients it is easy to perform and even more details are demonstrated in patients with atrophies of the mesodermal iris structure. In congenital albinism very fine vascular structures are demonstrated in younger patients; a similar picture is seen in pupillotonia if there is atrophy of the iris stroma. In senile iris atrophies, Adie's syndrome and congenital albinism the iris vascular structure is basically normal, but atrophy of the iris stroma may lead to increased fluorescein permeability in the elderly.

Adult↗