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Biomedical subjects

G Knapp

Publications and source records attributed to G Knapp.

49 records · Page 3Linked to original sources
PubMed1975

[Concepts and advantages of short tests in psychopathology].

The term 'short test' (Kurztest) can signify a number of diverse concepts. An attempt was made to arrange these concepts systematically. This may have practical significance, as short tests in psychopathology assume growing importance and the terminology for purposes of communication will become more differentiated and precise. Short tests need not be of lower quality than normal procedures. On the contrary, particularly in the area of psychopathology, short tests can have a higher validity and reliability.

Evaluation Studies as Topic↗
PubMed1975

[Serum concentration of triiodothyronine in autonomous thyroid gland adenoma].

Serum Concentration of T3 was measured in 14 patients with autonomous thyroid adenoma using a chromatographic method. 9 patients had increased levels of T4, 5 were normal. In both groups serum-T3-concentration was significantly elevated. In patients with normal T4-values hypertriijodothyroninemia seems to be the biochemical base for clinical signs of hyperthyroidism. The pathogenetical importance of elevated T3-levels is discussed for T3-secretion and T4/T3 conversion.

Adenoma↗
PubMedDate not supplied

Preliminary observations on dissolution and bioavailability of triamterene-hydrochlorothiazide combination products.

The dissolution profiles of two brands of triamterene-hydrochlorothiazide (TRM-HCT) combination tablets and two brands of TRM-HCT combination capsules were studied using the USP paddle method at 100 rev min-1 in acid medium (0.1N). The tablets represent two products marketed in Germany, whereas the capsules represent the approved innovator's product and an unapproved generic product. The tablets dissolved almost 100 per cent in 15 min whereas the capsules dissolved less than 25 per cent in 60 min. A pilot bioavailability study was carried out in four normal healthy male volunteers. Urine samples were collected over a 48 h period and analysed for TRM, its major metabolite TRM-sulfate, and HCT using HPLC methods. The dissolution characteristics of TRM can be associated with the total drug excretion (absorption) of the product. On the other hand, the excretion (absorption) of HCT was independent of dissolution characteristics of the products. However, in TRM-HCT combination product, there appears to be a 50 per cent reduction in HCT excretion (absorption) when compared to the reported excretion (absorption) from a marketed single-entity product.

Biological Availability↗
PubMedDate not supplied

Influence of dioctyl sodium sulfosuccinate on the absorption of tetracycline.

A pilot bioavailability study was carried out to evaluate the drug interaction and influence of dioctyl sodium sulfosuccinate (DS) on the absorption/bioavailability of tetracycline. Three tetracycline products--a fast dissolving capsule, a slow dissolving capsule and a suspension, were used in the study. DS was administered 30 minutes before tetracycline administration; and on -3, -2 and -1 day in the evening before tetracycline administration. Frequent urine samples were collected up to 48 hours and analyzed by a microbiological method. Although not statistically significant in this small study, the results suggest that there is a reduction in tetracycline bioavailability due to DS. The indiscriminate use of surface active agents to increase the dissolution rate of solid oral dosage forms in the belief that the resulting increased dissolution improves product bioavailability must be questioned.

Biological Availability↗
PubMedDate not supplied

Identification and quantification of 6 beta-hydroxydexamethasone as a major urinary metabolite of dexamethasone in man.

Identification of 6 beta-hydroxydexamethasone as a major urinary metabolite of dexamethasone in man has been accomplished by nuclear magnetic resonance spectroscopy and gas chromatography-mass spectrometry. Mass fragmentographic measurements revealed that more than 30% of the intravenously or orally administered dexamethasone dose was excreted in the 24-h urine as 6 beta-hydroxydexamethasone, while only a small fraction of the dose was excreted as unchanged dexamethasone and its glucuronic acid conjugate.

Adult↗