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Biomedical subjects

G Korb

Publications and source records attributed to G Korb.

At least 37 records · Page 2Linked to original sources
PubMed1981

[Relevance of immunofluorescence microscopy for diagnosis and prognosis of chronic hepatitis B (author's transl)].

109 patients with hepatitis B infections had 162 biopsies of the liver. The specimens obtained were investigated microscopically; at the same time existence and pattern of distribution of HBs and HBc antigens were looked for by immunofluorescence microscopy. In cases with a histologically established diagnosis of chronic aggressive hepatitis (CAH) the following patterns could be found: (a) focal occurrence of HBc in all cases, (b) pure cytoplasmatic HBs fluorescence (HBs type I), (c) pronounced HBs fluorescence at the cell membrane (HBs type II), or (d) pronounced HBs fluorescence at the cell membrane combined with cytoplasmatic HBs fluorescence in focal areas (HBs type III). The 3 HBs types could be associated with different clinical courses of CAH. A pure cytoplasmatic HBs fluorescence without HBc fluorescence could be found in about two thirds of the cases, which had been diagnosed as chronic persistent hepatitis (CPH) established by the first microscopic examination of the biopsy specimen. All cases deviating from this pattern could be classified at a later date as CAH also by histological criteria. In 25% of the cases the clinical course was protracted, the histological diagnosis having been at first: residual changes after acute hepatitis; in these cases the pattern of distribution of virus antigens in the biopsy specimen did allow already at an early date the diagnosis of CAH or CPH; this diagnosis could be confirmed by control biopsy and conventional microscopic examination in all these cases at a later date.

Adult↗
PubMed1980

[Influence of (+)-cyanidanol-3 on the course of acute viral hepatitis (author's transl)].

A double-blind study was conducted in four hospitals to test the effect of (+)-cyanidanol-3 (Catergen) on the course of acute viral hepatitis. Activities of a number of enzymes, bilirubin levels and gamma-globulin concentrations, as well as elimination of HBs antigen in blood were measured serially in 73 patients with viral hepatitis, 37 being treated with the drug, 36 patients receiving a placebo. In addition, liver biopsies before and after treatment were compared (19 patients treated, 23 patients on placebo). There was no significant difference between the treatment and placebo groups with regards to morphological and biochemical changes.

Adolescent↗
PubMed1980

Reduction of the isoproterenol-induced alterations in cardiac adenine nucleotides and morphology by ribose.

Continuous intravenous infusion of ribose (200 milligrams per kilogram per hour) for 24 hours induced a marked stimulation of cardiac adenine nucleotide biosynthesis in unanesthetized and unrestrained rats that had been treated with isoproterenol subcutaneously (25 milligrams per kilogram). The diminution of adenine nucleotides characteristic for the action of high doses of isoproterenol was entirely prevented, and the incidence of the isoproterenol-induced myocardial cell damage was significantly reduced when ribose was administered. These results support the view that depletion of adenine nucleotides is involved in the development of cardiac necrosis.

Adenine Nucleotides↗
PubMed1979

[Liver changes in giant-cell arteritis: temporal arteritis and rheumatic polymyalgia (author's transl)].

Liver changes were demonstrated in six elderly patients with giant-cell arteritis (temporal arteritis, three with polymyalgia). Histologically there was fatty infiltration in four and pericentral congestion in five, star-cell nodules in one and non-specific hepatitis in one. Bromsulphalein test was abnormal in all, but rapidly became normal as the arteritis was successfully treated with corticoids. The pathogenesis of the liver changes is unclear. The authors' observations and published reports suggest that they are typical of giant-cell arteritis; it is of importance in the diagnosis of underlying disease.

Adrenal Cortex Hormones↗
PubMed1977

[Occurrence of liver cell necrosis during surgery; histological findings of specimens obtained by biopsy during laparotomy (author's transl)].

Liver biopsy specimens were taken in 350 patiens during laparotomy and examined histologically. In 27.7% of all cases liver cell necrosis with invasion of granulocytes could be demonstrated, however only when biopsies were taken at least 45-60 min after start of surgery. There is no clear evidence, that the occurrence of this type of necrosis depends on the method of narcosis, the age of the patient, the severity or duration of the underlying disease, on the presence of cholangitis, cholestasis or fatty infiltration of the liver. Cell necrosis occuring during surgery arises primarily in the centrolobular areas as single cell necrosis; in rare cases however confluent and extended necrotic changes may occur. Etiology, pathogenesis and significance of the lesions are discussed. The frequency of other changes of the liver diagnosed inadvertently during these investigations is discussed as well.

Adult↗