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Biomedical subjects

G Kosekova

Publications and source records attributed to G Kosekova.

7 recordsLinked to original sources
PubMed1993

[Vasopressin as a neurotransmitter and neuromodulator].

Recent data about the antidiuretic hormone arginine vasopressin (AVP) are reviewed which show that except its well known peripheral endocrine functions, it has another not less important function as a neurotransmitter and neuromodulator in the central nervous system. AVP facilitates learning and memory consolidation. Data are also presented about the primary structure of AVP precursor and the sites of its synthesis, as well as about the AVP receptors and the mechanism of its action in different brain areas. Data are given about the ways of inactivation of its second messengers inositol-1,4,5-triphosphate and diacylglycerol. There are also data about AVP antipyretic effect in septum. A hypothesis is presented that the action of some nonsteroid antipyretic substances is mediated through V1-receptors of AVP in septum.

Animals↗
PubMed1993

[Problem solving of the clinical case-method type for the development of clinical thinking. The illustrative problem of galactosemia].

Problem-solving case approach is an effective method for teaching clinical concepts. This method makes medical students be aware of the significance of Biochemistry for the clinical practice. The students are stimulated to study basic biochemical principles. The complete text of a problem case on galactosemia is presented. This case, usually given to the students during the final seminar on carbohydrate metabolism reflects a real situation, in which the student feels responsible to make decisions. He has to make the diagnosis and prescribe a treatment. The student's actions are assessed and commented. The students took a great interest in that problem case and that shows that it is possible and necessary even in the second preclinical year to joint the theoretical principles with the future clinical practice.

Bulgaria↗
PubMed1981

[Effect of tyrosine-74-modified cytochrome C on electron transfer in Keilin-Hartree submitochondrial particles].

The tyrosine-74 modified cytochrome c is obtained by the interaction of cytochrome c with N-(2, 2, 5, 5-tetramethyl-3-carboxy-piroline-oxyl) Imidazol. The absorbtion spectrum of the modified derivative at the visible region does not differ substantially from the native protein. The band of absorbtion at 695 nm, which shows that the performed modification is soft and the conformation of the modified cytochrome c is close to that of the native protein. Redox potential of the modified cytochrome c, determined by spectrophotometric titration, does not differ from that of the native protein. Submitochondrial particles, deficient of cytochrome c, are reconstructed with modified protein. In both substrates of biologic oxidation succinate and ascorbate the electron transport is restored by the modified protein in considerably higher concentrations than those of the native cytochrome c. Inspite of small conformation differences and unchanged redox potential of the modified cytochrome c substantial differences are observed in its electron-carrying properties as well as its interaction with the membrane cytochrome c reductase and oxydase.

Animals↗