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Biomedical subjects

G Kowalska

Publications and source records attributed to G Kowalska.

11 recordsLinked to original sources
PubMed1999

[Brain functional imaging using magnetoencephalography].

Neuromagnetism, the study of neural function by the measurement of magnetic fields, is a new, quickly developing branch of science. Magnetoencephalography is the measurement of weak magnetic fields generated by neuronal activity in the human brain. By measuring the magnetic field evoked around the head, a map of the functional organisation of the brain can be deduced with a sub-centimetre spatial resolution and a millisecond temporal resolution. Although MEG has been used since the early 1970 s it is only recently that large multi channel facilities have been combined with sophisticated analysis techniques and Magnetic Resonance Imaging to provide a tool for fundamental study of the brain. The author presents 9 the other functional imaging tools such as Positron Emission Tomography /PET/, functional Magnetic Resonance Imaging /fMRI/ et Encephalography /EEG/.

Brain Diseases↗
PubMed1988

Genetic factors in myasthenia gravis: a family study.

We studied forty-four patients with myasthenia gravis (MG) and their families. Thirty percent of patients had a confirmed family history of autoimmune disease; in one case this was MG. In all the families with autoimmune disease, the affected relatives were related to the patients through the maternal line. HLA-B8 and DR3 were increased in patients due to the high incidence of these antigens in female, nonthymoma patients with onset before 40 years. HLA-B5 was increased in patients with older onset. The haplotype A1-B8-DR3 was not found to be increased given the presence of B8 or DR3.

Adolescent↗
PubMed1987

Occupational exposure to cadmium and kidney dysfunction.

Investigations were carried out in an alkaline battery factory. The study group consisted of 102 persons and the control group of 85 persons. Cadmium in blood (Cd-B) and cadmium in urine (Cd-U), as well as beta 2-microglobulin (B2-M), retinol binding protein (RBP), amino acids in urine were determined. Exposure to cadmium was high; Cd-B and Cd-U concentrations were higher than recommended, 10 micrograms/l and 10 micrograms/g creat. In 65% and 56% of workers, respectively. Excretion of B2-M and RBP in urine was higher than the accepted upper limits of 380 and 130 micrograms/g creat. in about 20% of the workers. A significant correlation was observed between: log Cd-U.log Cd-B (r = 0.85), log B2-M.log RBP (r = 0.66), log Cd-U.log B2-M (r = 0.52), and log Cd-U.log RBP (r = 0.55). To evaluate the admissible period of occupational exposure to cadmium, an integrated exposure index (Cd-B x years of exposure) is proposed. According to the dose-response relationship, an increase of low molecular protein excretion in urine can be expected in 10% of the cases at Cd-U amounting to 10 to 15 micrograms/g creat. and Cd-B x years of about 300 to 400.

Adult↗
PubMed1986

Morphometric studies of development of the rat testis under physiological conditions and after CdCl2 poisoning.

The morphometrical data of the rat testis were studied between the 1st day and 1.5 year of life under physiological conditions and after intraperitoneal injection of a single dose of cadmium chloride (1.5 mg CdCl2/kg body weight). Under physiological conditions three main period of development occur: between the 1st and 30th day of life, between the 30th and 45th day of life, and after the 45th day of life. The greatest changes after the injection of cadmium were noticed in the period between the 15th and 30th day of life. The periphery of the organ was the first to suffer severe damage.

Animals↗
PubMed1985

[Comparison of the levels of 6 metals in the blood of workers in the Bełchatów Industrial District before and after activation of the electric power station].

The concentration of six trace metals has been determined in the blood of 90 workers of the Bełchatów Industrial District after the electric power station start-off. The results have been compared with those related to the time before the start-off. The trace elements have been determined using the flameless atomic absorption (Cd, Pb, Mn), flame atomic absorption (Zn), or colorimetric methods (Fe, Cu). In those examined after the electric power station start-off, as compared to the group examined prior to the start-off, the following observations have been made:--similar average concentrations of toxic metals--cadmium and lead--in blood,--similar average concentrations of copper in serum,--higher average concentrations of manganese and ferrum in serum,--lower concentrations of zinc in serum. The differences might be due to changes in living conditions or increased exposure to the metals. The investigations further contribute to the prospective evaluation of the effects of the Bełchatów Industrial District upon the level of trace metals in the blood of the workers of that district.

Adult↗
PubMed1977

[Use of colored samples in the detection of occupational exposure to allergic effects of chromium and nickel compounds].

By using a coloured sample with diphenylcarbazide, chromium content in raw materials and industrial intermediate products was determined. At the same time chromium content was determined quantitatively by atomic absorption. The method was said to be simple and easy to be done in any industrial physician's conditions. The sample's sensitivity was said to be 1:100 000. Results of the determinations indicated that protective leather gloves contained considerable content of chromium, and chromium-free machine oils and lubricants were polluted with chromium's minute quantities as the oils and lubrications were being used. It was stated that coloured samples aiming at the detection of chromium, cobalt and nickel should be routinely used in preventive activity of industrial physicians.

Chromium↗
PubMedDate not supplied

Serum manganese concentration in healthy population of the city of Lódź.

The reported study was carried out in 80 healthy subjects from the population of the City of Lódź not exposed occupationally to metals. Manganese was determined by the method of atomic absorptiometry (method error +/- 12%). The concentration of manganese in the serum ranged from the values below the detectability of the method (below 0.10 micrograms/100 ml - 1 case) to 0.78 micrograms/100 ml, the mean value was 0.39 +/- 0.18 micrograms/100 ml (means +/- SD). No significant differences were found in manganese concentration in relation to age, sex and smoking.

Adolescent↗