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Biomedical subjects

G Krassas

Publications and source records attributed to G Krassas.

6 recordsLinked to original sources
PubMed1983

Thyrotoxicosis in pregnancy: results of treatment by antithyroid drugs combined with T4.

Treatment of thyrotoxicosis in pregnancy with antithyroid drugs plus supplementary T4 is controversial. Data are presented on twenty consecutive pregnancies treated by this method. The mean birth weights of the babies and their gestation did not differ from those of normal controls. Cord blood mean T4 and free T4 index (FT4I) were not significantly different from controls and total T3 and free T3 index (FT3I), though significantly lower than the controls, were all within the normal range. In five babies in whom they were measured, FT3, FT4 and rT3 levels were not significantly different from controls. Cord TSH was significantly higher in the babies of thyrotoxic mothers than in the control babies. One baby had a goitre at birth which disappeared after a few days. Another baby, born euthyroid, developed neonatal thyrotoxicosis the day after birth. Data collected from the literature on this method of treatment are compared with similar data from women treated with antithyroid drugs alone.

Adult↗
PubMed1981

Sotalol in hyperthyroidism.

Ten hyperthyroid patients were studied before and after 2 weeks' beta-adrenoceptor blockade with sotalol. The following variables were measured: resting pulse rate, blood pressure, weight, thyroid hormone levels, plasma lipids, alkaline phosphatase, plasma glucose and insulin responses to oral glucose, bromsulphthalein retention and the 24-h urinary excretion of calcium, hydroxyproline, creatine and creatinine. Sotalol produced a significant fall in pulse and blood pressure. Weight loss continued during treatment. No metabolic changes of any consequence were found. It is concluded that sotalol should not be used as the sole treatment of a patient with hyperthyroidism.

Adult↗
PubMed1977

Thyroid function and antibody studies in pernicious anaemia.

Thyroid antibodies were demonstrated in 57% of thirty pernicious anaemia patients without overt thyroid disease. Elevated basal thyroid stimulating hormone (TSH) levels and an enhaced TSH response to thyrotrophin releasing hormone (TRH) only occurred in thyroid antibody positive subjects; by contrast the thyroid antibody negative subjects in the older age group frequently and undetecable basal TSH levels and an impaired TRH response. Thyroid hormone concentrations provided no absolute evidence of hypothyroidism in any of the patients.

Adult↗
PubMed1977

The cardiovascular and lipid status of pernicious anaemia patients with and without thyroid antibodies.

A study has been undertaken of the cardiovascular and lipid status of patients with pernicious anaemia (PA). There was no evidence of elevated cholesterol, triglyceride and lipoprotein concentrations nor of an increased prevalence of ischaemic heart disease and peripheral vascular disease in those patients who had positive thyroid antibodies compared with those who had not. There were also no significant differences in cardiovascular or lipid status in the antibody positive patients between those who had an exaggerated thyroid stimulating hormone (TSH) response to thyrotrophin releasing hormone (TRH) and those who had a normal or impaired response. It is suggested that an exaggerated response to TRH in these PA patients usually indicates 'compensated euthyroidism' and not 'subclinical hypothyroidism' or 'premyxoedema' and that they are no more at risk for cardiovascular disease than are PA patients with no evidence of thyroid abnormality.

Adult↗