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Biomedical subjects

G L Anderson

Publications and source records attributed to G L Anderson.

At least 91 records · Page 5Linked to original sources
PubMed1981

Synthesis and evaluation of some stable multisubstrate adducts as inhibitors of catechol O-methyltransferase.

A new series of methylase inhibitors has been designed in which the nucleophilic methyl acceptor is attached to the adenosine and/or homocysteine fragments of the methyl donor, S-adenosylmethionine, to form a "multisubstrate adduct". In the present case, catecholamine analogues attached through a phenethyl sulfide linkage to 5'-thioadenosine or homocysteine have been synthesized, together with the corresponding methylsulfonium salts. These compounds were assayed as inhibitors of catechol O-methyltransferase, and the adenosylsulfonium salts (4) were found to be inhibitors of the enzyme.

Catechol O-Methyltransferase Inhibitors↗
PubMed1979

Induction of myeloperoxidase deficiency in granulocytes in lead-intoxicated dogs.

Lead interferes with heme synthesis in erythrocytes and has a deleterious effect on red cell membranes. We measured myeloperoxidase (MPO) enzyme activity in the granulocytes of dogs fed increasing quantities of lead. Concurrently, iodination capability and in vitro bactericidal activity were measured. Blood lead levels were monitored. Three of 4 dogs poisoned with lead developed significant decreases in MPO enzyme activity in their granulocytes. The decline in MPO activity correlated with cumulative lead toxicity as judged by blood lead levels and clinical signs of lead poisoning. Iodination ability in all 4 dogs decreased with cumulative lead toxicity. After discontinuation of lead administration, recovery of granulocyte MPO activity preceded recovery of iodination ability. This observation suggests the possibility of separate effects of lead on iodination ability and MPO activity. Moderate impairment of bactericidal capacity developed in 3 of 4 dogs with severe lead poisoning. Clinical infections were not observed during the course of the study.

Animals↗
PubMedDate not supplied

Poor surgical technique produces more emboli after arterial anastomosis of an island flap.

To answer the question "Are more emboli produced after a small artery anastomosis has been performed poorly?", we used the isolated rat cremaster muscle. The number of emboli seen downstream from a small artery anastomosis were counted after using two anastomotic techniques. Direct observations using intravital microscopy of emboli passing through the principal arteriole of the cremaster revealed that surgical technique using a large needle (poor execution) caused a significantly higher number of emboli to be produced at the site of small artery anastomosis than was noted after a fine needle technique.

Anastomosis, Surgical↗
PubMedDate not supplied

A comparison of trends in mortality from stroke in the United States and Rochester, Minnesota.

More uniform methods of diagnosis and determination of the cause of death result in greater reliability of trends in mortality from stroke. In all categories of stroke except subarachnoid hemorrhage, the mortality rates in Rochester, Minnesota, are lower and show a more rapid decline with time than in the United States as a whole. The differential between the rates for United States white population and the Rochester population is most evident in the older age groups. This difference may be due to the effects of revisions in the International Classification of Disease and/or to the assignment of nonstroke deaths to stroke causes in the United States as a whole to a greater extent than in Rochester. Whether different patterns of medical care affect the trends in stroke mortality has not been determined. The trends in mortality from various categories of stroke in Rochester are reliable because some of the inconsistencies of diagnosis, assignment of cause of death, and coding changes have been overcome. The decline in mortality rates for Rochester corresponds well with decreasing incidence rates and lack of change in case fatality rates previously reported.

Aged↗