Biomedical subjects

G L Bach

Publications and source records attributed to G L Bach.

44 records · Page 3Linked to original sources

PubMedDate not supplied

[Therapy of non-steroidal antirheumatic drug-induced gastrointestinal lesions with misoprostol].

In a multicenter placebo-controlled double-blind study in patients with degenerative or inflammatory rheumatic diseases the prostaglandin analogue misoprostol, in a dose of 200 micrograms twice daily after meals, was administered for the treatment of NSAID-induced lesions and symptoms of the upper gastrointestinal tract. Treatment with an NSAID was continued. Misoprostol treatment was demonstrated to be clearly superior to placebo in respect of reduction of gastroduodenal lesions and gastrointestinal pain. In addition, the physician's global assessment of gastrointestinal complaints was also statistically significantly better. No difference between the groups was found with respect to antirheumatic action of the NSAIDs.

Anti-Inflammatory Agents, Non-Steroidal↗

PubMedDate not supplied

[Benorylate and indomethacin in cervical syndromes: a comparative double-blind study].

In a double-blind study the effectiveness of benorylate and indomethacin was compared in patients suffering from cervical spine syndromes. From a total of 60 patients, 30 individuals (group A) received 100 mg of indomethacin/day and 30 (group B) were treated with 6 g of benorylate per day. Clinical improvement as judged by several given criteria occurred in 80% of the patients in group A and in 76.7% of the patients in group B. If strict objective criteria (ie. increased mobility) were used, 53.3% improved in both groups, while subjective criteria revealed improvement in 76.7% in both groups. Neurological signs improved in 36.7% in group A and in 30% in group B. In two patients treatment with indomethacin was discontinued because of severe side effects. In the benorylate treated group 3 patients had to be taken off treatment for the same reason. Side effects were mainly gastro-intestinal. The study indicates that with regard to clinical effectiveness benorylate is comparable to indomethacin in patients suffering from cervical spine syndromes; the substance is cheap and relatively tolerable.

Adult↗

PubMedDate not supplied

[Ulcer healing with ranitidine and antacids despite continued therapy with non-steroidal anti-rheumatic drugs].

The aim of this study was to investigate the course of gastric and duodenal ulcers under ranitidin and antacid treatment during continuous NSAID therapy, and to answer the question of whether ulcers are an absolute contraindication for NSAID treatment. A total of 21 patients (17 females; four males; average age 58 years) with rheumatoid arthritis (18 patients), ankylosing spondylitis (two patients), and cervical spine syndrome (one patient) with gastric and/or duodenal ulcers, demonstrated by endoscopy, entered the study. Because of the severe course of the rheumatic disease present in every patient, there was a need to continue NSAID therapy. Gastric or duodenal ulcers were treated with 300 mg ranitidin and an aluminium-magnesium-hydroxide-containing antacid with an acid binding capacity of 280 mval/day. The course of healing of the ulcers was checked endoscopically and in part by biopsies (gastric ulcers). Within the period of 31 +/- 11 days, all duodenal ulcers under observation had healed. Of the gastric ulcers, 50% had healed completely while the others showed definite improvement. NSAID-induced ulcers were located in or close to the pylorus, contrary to the location of peptic ulcers. These data show that NSAIDs--if administration is absolutely necessary because of the severe course of the rheumatic disease--can be continued even in the presence of gastric or duodenal ulcers when administered with ranitidin and antacids. Because of hemorrhage and perforation in NSAID-induced ulcers, close clinical and endoscopic checks are necessary. Failures, even with the use of H2-blockers, have also been described.

Aged↗

PubMedDate not supplied

[Flurbiprofen and indomethacin in chronic polyarthritis and gonarthrosis - a comparative multicentric double-blind cross-over study].

In two multicenter double-blind cross-over studies efficacy and safety of flurbiprofen and indomethacin were compared. Nineteen patients with rheumatoid arthritis and twenty with osteoarthrosis of the knee were treated. Both drugs were effective and almost equal. Also safety was good, however three patients on indomethacin and one on flurbiprofen had to be withdrawn from the trial because of side-effects.

Aged↗

PubMedDate not supplied

[Nasal septum perforation in disseminated lupus erythematosus, case report and literature review].

Perforation of Nasal Septum in Systemic Lupus Erythematosus: Report of a Case and Review of the Literature. Perforation of the nasal septum in systemic lupus erythematosus (SLE) is rare. Report of a case and review of the literature revealed the total of 13 patients with this lesion. There was only one male. The complication is most likely to occur during an exacerbation of SLE months or years after the diagnosis has been established. Epistaxis is a constant initial symptom. A frequent association with the Raynaud's phenomenon favours speculations, that the lesion may be due to local vasospasms following exposure to cold inspired air. The septum perforaton gradually increases in most cases virtually independent from drug treatment and favouring conservative management.

Adolescent↗

PubMedDate not supplied

[Glycosaminoglycanpolysulfate (GAGPS, Arteparon) for basic therapy of arthrosis. I. Comparative studies, Arteparon forte and physical therapy vs. physical therapy alone].

Glycosaminoglycan polysulphate (GAGPS, Arteparon) is effective as a fundamental therapeutic agent in arthrosis (osteoarthritis). Patients with gonarthrosis and coxarthrosis of activity grade II received intramuscular Arteparon forte injections and physical therapy (group 1, n = 69) or physical therapy only (group 2, n = 46). In group 1 23 patients (33.3%) became free of pain as compared to 3 patients (6.5%) in group 2. No therapeutic success was obtained in 6 patients of group 1 (8.7%) and in 14 individuals (30.4%) of group 2.

Adult↗

PubMedDate not supplied

[Glycosaminoglycanpolysulfate (GAGPS, Arteparon) for basic therapy of arthrosis. II. Comparative studies, Arteparon forte and physical therapy vs. physical therapy alone; late results].

Five to 9 months after a comparative study of 2 groups of patients with coxarthrosis and gonarthrosis, 69 individuals (group 1) receiving Arteparon forte injections and physical therapy and 46 persons (group 2) with physical therapy only, questioneer with specific questions was sent out. From 72 questioneers mailed 55 were returned to the investigators of the study. 53 questioneers were suitable for evaluation: 40 in the group 1 and 13 in group 2. 62.5% of the patients in group 1 described their condition improved as compared to 30.8% in group 2. In 46.1% of the patients in group 2 the condition had deteriorated; this occurred in only 17.5% of group 1.

Adult↗

PubMedDate not supplied

[Glycosaminoglycanpolysulfate (GAGPS, Arteparon) for basic therapy of arthrosis. III. Biochemical-diagnostic and clinical studies on the intramuscular use of GAGPS].

Investigations using 3H-Arteparon (3H-glycosaminoglycan polysulfate, 3H-GAGPS) showed that in humans with degenerative joint disease an intramuscular administration of 125 mg GAGPS (0.5 ml Arteparon forte) produces GAGPS concentrations within the joint, which in a biochemical assay inhibit cartilage degrading lysosomal enzymes. The dosage was determined from animal experiments that had indicated the relationship between the applied quantity of the drug and the resulting biological concentrations. Preliminary results of treatment with 0.5 ml Arteparon forte in 15 patients are reported.

Animals↗