New physical sign during myocardial ischemia--limb venous engorgement, nine cases.
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Arm↗
Biomedical subjects
G L Haycraft
Publications and source records attributed to G L Haycraft.
Myocardial oxygen supply-demand ratio: a validation of peripherally vs centrally determined values.
We sought to validate that the supply-demand ratio for myocardial oxygen could be accurately measured from tracings of peripheral as well as central arterial pressure. This ratio was the ratio of the diastolic pressure-time-index (DPTI) over the systolic pressure-time index (SPTI). Sixteen patients had the peripheral DPTI/SPTI determined at cardiac catheterization by the following two different methods: (1) P1, using the mean diastolic and systolic peripheral arterial pressure and the ratio of the duration of diastole and systole; and (2) (P2, where the peak systolic and diastolic peripheral arterial pressures are used, eliminating the need for planimetric data. The results of P1 and P2 correlated closely with the central value (r = 0.96 and 0.92, respectively). We conclude that DPTI/SPTI can reliably be measured from a tracing of peripheral arterial pressure, enabling reliable continuous monitoring of this ratio.
Adolescent↗
Hemoglobin S Travis: a sickling hemoglobin with two amino acid substitutions [beta6(A3)glutamic acid leads to valine and beta142 (h20) alanine leads to valine).
Hb S Travis is a previously undescribed sickling hemoglobin with two amino acid substitutions in the beta chain: beta6 Glu leads to Val and beta142 Ala leads to Val. The beta6 Glu leads to Val mutation imparts to Hb S Travis the characteristic properties of sickling hemoglobin, namely its association with erythrocyte sickling, the insolubility of the hemoglobin in the reduced form, and a minimum gelling concentration value identical to Hb S. Unlike Hb S, Hb S Travis exhibits an increased oxygen affinity and a decreased affinity for 2,3-bisphosphoglycerate and inositol hexakisphosphate. In addition, the variant hemoglobin's tendency to autoxidize and its mechanical precipitability suggest that there are conformational differences between Hb S and Hb S Travis.
Alanine↗