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Biomedical subjects

G L Henson

Publications and source records attributed to G L Henson.

4 recordsLinked to original sources
PubMed1991

Head circumference/abdominal circumference ratio, ponderal index and fetal malnutrition. Should head circumference/abdominal circumference ratio be abandoned?

Head circumference/abdominal circumference (HC/AC) ratios of the fetus are accepted as a means of distinguishing different patterns of growth retardation with a high ratio implying malnutrition of the fetus. Ponderal index (birthweight/length3) is used by paediatricians as a measure of neonatal wasting and would therefore be expected to correlate with HC/AC ratios at delivery. Anthropometric data on 999 newborn infants have been collected and analyzed by multiple regression. The results show a poor correlation between ponderal index and HC/AC ratio, worse than that between ponderal index and AC alone. The use of HC/AC ratios antenatally to identify subgroups of intrauterine malnutrition should be abandoned. The prediction of intrauterine malnutrition by weight/length ratios should be investigated further.

Anthropometry↗
PubMed1983

Antenatal fetal heart-rate variability in relation to fetal acid-base status at caesarean section.

A quantitative comparison was made of fetal heart-rate (FHR) traces obtained shortly before delivery, and of umbilical artery blood gas values, in 49 women delivered by caesarean section for reasons other than fetal compromise and in 23 women delivered by section for antenatal fetal compromise judged from visual inspection of conventional FHR recordings. The FHR traces in the compromised group of fetuses were abnormal, with low variability and a high incidence of decelerations, but there was no significant difference from the normal group in metabolic acidaemia, as judged by the base excess of umbilical artery blood. The compromised group consisted almost exclusively of infants small-for-gestational age. These results suggest that the FHR pattern of the compromised fetuses is not the direct result of intrauterine asphyxia but of some other factor associated with growth retardation.

Acid-Base Imbalance↗
PubMedDate not supplied

Birthweight for length: ponderal index, body mass index or Benn index?

This study compares how effectively the ponderal index and the body mass index adjust birthweight for length at different gestations, and derives an improved index suitable for all gestations. The study was a cross-sectional survey, in a London teaching hospital, using a total of 999 neonates of 33 weeks gestation or later. Main outcome measures were the ponderal index (birthweight/length3), body mass index (birthweight/length2), and Benn index (birthweight/length(n)), where the length power n varies with gestation and is estimated by log-log regression. Results showed that up to 39 weeks gestation, the ponderal index is uncorrelated with length and so is a good index of birthweight for length. Past 39 weeks gestation, the ponderal index is negatively correlated with length, while the body mass index is uncorrelated, so that the body mass index is better. Neither index is optimal at all gestations. Deriving the Benn index (birthweight/length(n)) for each week of gestation, choosing n to make the index uncorrelated with length, shows that n falls steadily and very significantly (p < 0.0001) with increasing gestation. This in turn means that predicted birthweight for length depends on gestation: for a neonate 48 cm long, predicted birthweight varies from 2485 g at 34 weeks to 3030 g at 43 weeks, a 20% range. However, for a 54 cm long infant, predicted birthweight is the same at all gestations. A Benn index where the value of n changes linearly with gestation is described. We conclude that the ponderal index is not appropriate for measuring intra-uterine malnutrition, as it fails to adjust for length at all gestations. No other index of birthweight/length(n) with constant n is any better, as different gestations require different indices. Birthweight predicted from an infant's length depends on the infant's gestation. If, as Barker proposes, thinness at birth assessed by birthweight for length is used to predict later health status, more account needs to be taken of the complex relationship between birthweight, length and gestation.

Birth Weight↗