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Biomedical subjects

G L Newstead

Publications and source records attributed to G L Newstead.

3 recordsLinked to original sources

Logical clinical decisions in the investigation and management of non-urgent rectal bleeding.

The benefits of assessment for non-urgent rectal bleeding derive from a combination of yield, risk factors, cost and patient comfort. Prospective studies have been completed which assign patients to investigative and management programmes based on graded bleeding patterns, the yield and true extent of flexible sigmoidoscopy and the safety and efficacy of immediate anorectal management. Between 1986 and 1989, 2268 new patients with bleeding were categorised by symptom grouping and entered into programmes of investigation and management. Flexible sigmoidoscopy (n = 936) eliminated or identified proximal bleeding in most (n = 882; 94.23%) and was confirmed to be generally specific for sigmoid assessment by "blinded" image intensifier confirmation of the level reached. No cancers are known to have been missed by clinical categorisation of patients. Between 1985 and 1988, 2112 patients underwent immediate sclerotherapy and triple banding for haemorrhoids, Significant secondary bleeding occurred in 9 patients (0.43%) and moderate to severe pain in 45 (2.13%) No deaths occurred. Further therapy to residual mucosal pedicles was required in 234 patients (11.08%) at one month, in 135 (6.39%) at a further month, and 67 patients (3.18%) subsequently. Careful clinical assessment, immediate investigation and management of the majority of anorectal disease in an ambulatory setting has been shown to be safe, highly cost efficient and relatively comfortable.

Ambulatory Care

Bowel preparation with mannitol.

Orally administered mannitol has been used for colonic preparation before operations, for colonoscopy, and before barium enema X-ray examinations. It is quick, effective, comfortable, safe, and cheap. The metabolic effects have been evaluated and found to be minimal, and recommendations for the use of orally administered mannitol are given.

Administration, Oral

Fibrinolytic activity of carcinoma of the colorectum.

Twenty patients with carcinoma, mostly of the colorectum, and five without malignant tumors who were used as controls, have been investigated to elucidate the relationship between tumor fibrinolytic activity and the release of circulating malignant cells. The nature of the tumor fibrinolytic activity has been considered. The most significant fibrinolytic activity was seen in blood draining from the tumors and was evident in 80 per cent. Circulating malignant cells were recovered from half the patients, and in those with significant blood fibrinolysis, recovery from the draining vein reached 89 per cent. The most undifferentiated tumors appeared to be more active and released more cells. Fibrinolytic activity of tumor tissue derives from inflammatory cells, dead tumor cells, avascular areas of the tumor and vascular endothelium and is probably proteolytic as well as purely fibrinolytic.

Colonic Neoplasms