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Biomedical subjects

G L Paris

Publications and source records attributed to G L Paris.

12 recordsLinked to original sources

Treatment of refractory orbital pseudotumors with pulsed chemotherapy.

Five patients with orbital pseudotumor refractive to initial therapy are discussed. Three had a destructive granulomatous process associated with a sclerosing component. Two exhibited a predominantly lymphocytic infiltration. Chemotherapy with Prednisone (100 mg/day) and either Cytoxan (100 mg/day) or Chlorambucil (10 mg/day) in 5-day pulses is described. All patients responded clinically to this treatment without unfavorable side effects.

Adult↗

Repair of the contracted socket using RTV silicone as a stent for mucosal grafting.

The anophthalmic socket is often contracted due to a deficiency of conjunctiva. The use of buccal mucosa to expand the socket is well known to ophthalmologists. However, this material often suffers shrinkage due to excessive scarring following surgery, leading to further contracture of the socket. RTV silicone (Medical Elastomer 382) has been found to be an excellent stent following buccal mucosal grafting. This paper deals with technical aspects of performing this procedure and discusses the complications. The results in 17 of 21 sockets have been excellent in allowing the conjunctival graft to take without further shrinkage and in allowing the patient to wear a prosthetic eye comfortably.

Anophthalmos↗

Salicylate-induced bleeding problem in ophthalmic plastic surgery.

A 54-year-old woman with clinically asymptomatic PCV underwent eyelid surgery. Twenty-four hours after an uncomplicated procedure she had a severe bleeding diathesis following the ingestion of a small amount of aspirin. Treatment of her bleeding disorder and a review of the effects of salicylates on platelet function are discussed.

Aspirin↗

Correction of enophthalmos in the anophthalmic orbit.

Enophthalmos with an associated superior sulcus syndrome is a common finding in the anophthalmic socket. Two common causes are: (1) progressive relaxation of the lower eyelid leading to downward migration of the prosthesis and associated ectropion formation; and (2) decreased volume of the orbit. Relaxation of the lower eyelid is corrected with repair and support using autogenous fascia lata. Decreased volume of the orbit is corrected with implantation of RTV silicone. The surgical techniques, surgical complications, ocular prosthetic modifications and follow-up on 20 patients are discussed.

Eye, Artificial↗

The O-to-Z plasty.

Closure of circular defects in the eyelids and canthal areas, as well as the face and neck regions, can present a challenging problem for the ophthalmic plastic surgeon. The O-to-Z plasty devised by Dr. Marvin Quickert is an excellent procedure for dealing with medium-sized circular defects in these regions. It is most commonly used after removal of benign or malignant tumors. In this procedure, skin is undermined from subcutaneous tissue and muscle around the entire circular defect. Two parallel incisions are made along normal lines of cleavage tangential to the circular defect. This allows the skin edges to be advanced and closed along a diagnol converting the defect to a Z closure. The advantage of this procedure is that it allows a smooth firm closure without a "dog-ear" defect. In addition, skin grafts can be avoided in closing many small- and moderate-sided circular defects.

Eyelid Neoplasms↗

Uses of RTV silicone in orbital reconstruction.

In a five-year follow-up of 42 patients with unsatisfactory cosmetic results after enulceation, room-temperature vulcanizing (RTV) silicone was used in the surgical correction of enophthalmos and superior sulcus depression. RTV silicone with a catalyst was placed in a dissected pocket subperiosteally along the floor and lateral wall of the orbit to correct the volume deficit. When vulcanizing in situ into soft silicone rubber, the implant conformed to the orbital wall and did not migrate. We determined tissue tolerance to in situ vulcanizing silicone histologically in 30 rats by inserting prevulcanized and in situ vulcanized material in paired subcutaneous pockets. No statistical difference was noted between the two methods. In 11 cases, the same material was used as a convenient stent to maintain the pressure over a graft and to maintain socket size after the reconstruction of a contrated socket, by filling the socket with RTV silicone which surrounded a Kirschner wire drilled through the lateral orbital rim.

Animals↗