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Biomedical subjects

G L Tadini

Publications and source records attributed to G L Tadini.

7 recordsLinked to original sources
PubMed1995

Tuberculosis cutis miliaris disseminata due to multidrug-resistant Mycobacterium tuberculosis in AIDS patients.

Two patients with AIDS and disseminated tuberculosis characterized by cutaneous involvement are reported. They developed a maculopapular skin eruption, from which a multidrug-resistant Mycobacterium tuberculosis strain was isolated. In both cases the clinical course was rapidly fatal. Tuberculosis cutis miliaris disseminata should be differentiated from the skin lesions frequently seen in HIV-infected patients, especially from folliculitis. In patients with tuberculosis, the appearance of cutaneous lesions may be due to the haematogenous dissemination of mycobacteria. Therefore, early identification of the causative organism by use of optimal microbiological methods is fundamental.

Acquired Immunodeficiency Syndrome↗
PubMed1993

Encephalocraniocutaneous lipomatosis: case report and review of the literature.

Encephalocraniocutaneous lipomatosis is a congenital disorder characterized by unilateral cerebral malformations and ipsilateral scalp, face, and eye lesions. Distinguishing histopathologic features are dysgenesis and neoplasia of the adipose tissue. A Caucasian boy had soft tumors and elastic papules on his head since birth, associated with atrophic areas, and a bilobed lesion on the upper right eyelid. On the bulbar conjunctiva of the right eye, an oval 6-mm lesion was present. Ultrasonogram, computerized tomographic scan, and magnetic resonance imaging revealed a dilation of the right lateral ventriculus, a mass on the pontocerebellar angle, agenesia of the corpus callosum, an arachnoidal cyst on the right hemisphere, microcalcifications, and pachygyria. The histology of a soft cutaneous tumor was consistent with a fibrolipoma, and dispersed extracellular lipid globules in the upper dermis were found on electron microscopy. The diagnosis suggested by these findings was encephalocraniocutaneous lipomatosis. Even in view of the rarity of the syndrome (11 cases described in the literature), this patient seems unusual because of the bilateral distribution of the cutaneous lesions and because of the agenesia of the corpus callosum. The peculiar ultrastructural findings require further confirmation.

Brain Neoplasms↗
PubMed1990

[Structural and ultrastructural study of an isolated case of pili annulati].

A case of pili annulati in an eighteen year old woman is described. The hairs show bright spots along hair shafts when viewed in daylight. The transmission and scanning electron microscopy confirmed that the bright spots are due to small cavities into the cortex. The plasmatic measurement of copper, zinc and of the most important hormone, such as the dosage of plasmatic, urinary and hair aminoacids, allowed the Authors to exclude any influence of metabolic systemic alterations on the pathogenesis of pili annulati. Neither cutaneous nor internal anomalies were detected.

Adolescent↗
PubMed1987

Arachidonic acid and LTB4 enhance aggregation of psoriatic peripheral blood mononuclear leukocytes in vitro.

The aim of the reported series of experiments was to examine the possible role played by arachidonic acid (Aa) derivatives in monocyte aggregation in psoriasis. Twenty patients with active plaque-type psoriasis covering not less than 20% of body surface area and 20 age-matched controls were investigated. Peripheral blood monocytes were harvested according to the technique recently set up by Colotta et al. These preparations usually contained more than 95% monocytes, as assessed by morphology and esterase staining. Aggregation tracings were plotted using a common platelet aggregation recorder system and expressed in arbitrary units. Aa sodium salt, acetylsalicylic acid (ASA), indomethacin, nordihydroguaiaretic acid (NDGA), and leukotriene B4 (LTB4) were used during testing. Aa induced an enhanced aggregation of mononuclear leukocytes (MNL) in psoriatic patients versus normal controls in a concentration-dependent way. Furthermore, neither ASA nor indomethacin inhibited Aa aggregation, while both markedly increased the aggregation response in psoriasis. LTB4 induced an enhancement aggregation in psoriasis, whereas NDGA strongly inhibited it. Although the pathophysiological significance of MNL aggregation described here remains obscure, assembly of the cells at the site of psoriatic skin might be a crucial event.

Adult↗
PubMed1984

Hyper IgE syndrome: four case report.

Patients with hyper IgE syndrome (HIES) have varying degree of immunological unbalance that account for deficiency of total T and OKT8 lymphocytes. To investigate the role of immunostimulating drugs in HIES, thymostimulin (TP1) and levamisole were given in highly controlled groups of patients after a wash out period with disodium-chromoglycate (DSCG). Both drugs do not modify clinical picture whereas they do modulate some laboratory parameters as T lymphocyte total number, IgE plasmatic concentration, neutrophil chemotaxis. Furthermore TP1 had a worsening clinical effect in 3 of our patients. In our opinion we feel that the therapies proposed and employed so far for this rare disease must be critically analyzed.

Antibodies, Monoclonal↗
PubMedDate not supplied

Phakomatosis pigmentovascularis: A new case with renal angiomas and some considerations about the classification.

We report phakomatosis pigmentovascularis detected in a Caucasian child characterized by the presence of a nevus flammeus and nevus anemicus on the face, a telangiectatic linear nevus of the right leg, and a very extensive blue spot covering 60% of the body surface, with ocular melanosis. Multiple angiomatous lesions of the kidney are associated without alterations of the central nervous system (CNS). This association has not been reported before; it could be a further expression of the complex of developmental defects. Our case corresponds exactly to type IIb in the classification of phakomatosis pigmentovascularis proposed by Hasegawa. As this classification seems very extensive, the higher incidence of cases corresponding to the second subtype suggests that we should identify it by the term phakomatosis pigmentovascularis, while the others could be considered as only very uncommon variants.

Facial Neoplasms↗