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Biomedical subjects

G L Weisbrod

Publications and source records attributed to G L Weisbrod.

52 records · Page 3Linked to original sources

Percutaneous fine-needle aspiration biopsy of mediastinal lesions.

Percutaneous fine-needle aspiration biopsy (PNAB) of mediastinal masses was carried out in 116 patients. The technique yielded a high percentage of correct diagnoses, and the results were usually available within hours. More importantly, the procedure was well tolerated by patients, and in this series of 116 cases, only one serious complication was encountered. There was a high accuracy (90.3%) in the cytologic diagnosis of mediastinal metastases from lung and extrathoracic sites. Excellent results were also achieved with the cytologic diagnosis of thymoma (82.4%). Very good results were achieved with benign mediastinal cysts, and PNAB with aspiration of fluid proved to be a valuable tool in the diagnosis of these lesions. The results achieved with the cytologic diagnosis of lymphoma supported by pathology (66.7%) and with neurogenic tumors were acceptable, but less impressive.

Aged↗

Nepheline rock dust pneumoconiosis. A report of 2 cases.

Two cases of nepheline rock dust pneumoconiosis are presented. Radiologically, this is seen as a diffuse increase in interstitial lung markings, lymphadenopathy, air-space disease, and atelectasis secondary to extrinsic compression by enlarged hilar lymph nodes. Major differential diagnoses include carcinoma of the lung, sarcoidosis, and interstitial lung disease caused by other inorganic dusts. Nepheline rock dust pneumoconiosis should be considered when the above radiological changes are observed and an occupational exposure to inorganic dust is documented.

Aluminum Compounds↗

Cardiac tamponade as a complication of thin-needle aspiration lung biopsy.

Thin-needle aspiration lung biopsy has become an important diagnostic technique in chest disease. Complications, other than pneumothorax, are infrequent. We report a case of acute cardiac tamponade complicating biopsy of a lesion near the mediastinum. Caution should be exercised in selecting patients for, and in performing biopsies in, or close to the mediastinum.

Adult↗

Pulmonary kaolin granulomas.

We report a patient with multiple pulmonary kaolin granulomas. The granulomas developed secondary to the use of a liquid kaolin suspension for pleural poudrage to treat recurrent spontaneous pneumothoraces. Presumably the kaolin entered the lung through pleuro-alveolar or pleuro-bronchial openings. Kaolin pneumoconiosis is generally regarded as an inhalational pneumoconiosis. However, on rare occasions kaolin may incite lung damage by the mechanism described above.

Adult↗

Pulmonary alveolar proteinosis: relationship to silicosis and pulmonary infection.

Pulmonary alveolar proteinosis is a rare disease with varied radiographic and clinical manifestations. Thirteen patients are presented and the role of pulmonary lavage in management is illustrated. Six patients had associated diseases such as nocardiosis, leukemia, and silicosis. The broad spectrum of relationships found in alveolar proteinosis suggests that it represents one mechanism by which the lung responds to a variety of insults.

Adolescent↗

Exogenous lipoid pneumonitis.

The clinical and radiologic diagnosis of exogenous lipoid pneumonitis often goes unrecognized. A specific history of lipoid aspiration is rarely obtained unless specifically sought. We analysed the clinical, radiologic and pathologic findings in 11 patients with pathologically-proven exogenous lipoid pneumonitis. Lipid aspiration results in a predictable pathologic and consequently radiologic pattern of disease, often simulating bronchogenic carcinoma. Transthoracic percutaneous fine-needle aspiration biopsy is useful as a complementary procedure to bronchoscopy in making the diagnosis.

Adult↗

Unusual manifestations of pulmonary aspergillosis.

Pulmonary aspergillosis is being diagnosed with increasing frequency, particularly in larger referral centers. The spectrum of lung pathology can be classified into 3 major groups: A) non-invasive mycetoma; B) allergic bronchopulmonary aspergillosis and C) invasive aspergillosis. Five patients with pulmonary aspergillosis are presented, illustrating unusual features of each major group. Transthoracic needle aspiration biopsy was diagnostic in 3 patients. It is important to differentiate a mycetoma developing in a pre-existing cavity from a cavitating Aspergillus abscess. The radiologic appearances may be similar, but evolution of the 2 lesions is entirely different.

Adult↗

Transthoracic needle biopsy.

Percutaneous fine-needle aspiration biopsy is a relatively simple invasive procedure with good patient acceptance, low morbidity, and almost negligible mortality. It provides a diagnosis of pulmonary, hilar, and mediastinal masses quickly and accurately, thus eliminating many laboratory tests, saving hospital days, and thereby saving time and money. Percutaneous fine-needle aspiration biopsy should be performed early in the investigation of many types of intrathoracic lesions.

Biopsy, Needle↗

Mycobacterium xenopi pulmonary infection: evaluation with CT.

PURPOSE: Our goal was to describe the CT appearances of Mycobacterium xenopi pulmonary infection. METHOD: A retrospective study period of 75 months was used. Eight immunocompetent patients fulfilled the American Thoracic Society criteria for M. xenopi infection and had CT scans of the thorax. CT scans were reviewed by two observers, and decisions were reached by consensus. RESULTS: Seven patients demonstrated upper lobe cavitary disease: one mass with cavity, one nodule with cavity, three consolidation with multiple cavities, and two cavities only. One patient demonstrated upper lobe consolidation only. All patients demonstrated adjacent lung architectural distortion indicating fibrosis and centrilobular nodules suggesting endobronchial spread of infection. Seven patients had a clinical history of preexisting chronic obstructive pulmonary disease that was confirmed by CT. Four patients demonstrated adjacent pleural disease. CONCLUSION: M. xenopi pulmonary infection usually affects patients with preexisting pulmonary emphysema. It predominantly affects the upper lobes, usually with cavitary opacities and evidence of fibrosis and endobronchial spread of infection.

Aged↗