Biomedical subjects
Publications and source records attributed to G Laban.
The existence of a new crystalline modification of the analgesic and antiinflammatory agent piroxicam was predicted. A model of the structure was derived from the crystal data of the alpha-modification. Lattice constants and molecular packing parameters were refined using X-ray powder diffraction data.
The anti-inflammatory drug piroxicam, 4-hydroxy-2-methyl-N-(2-pyridyl)2H-1,2- benzothiazine-3-carboxamide-1,1-dioxide, crystallizes in three different forms, two anhydrates and one monohydrate. Crystal structure analyses of the monohydrate and one of the anhydrate were carried out by Bordner et al. and Kojić-Prodić et al., respectively. In this paper the results of the analysis of the third piroxicam modification and of an independently performed structure determination of the monohydrate are reported. Molecular structures and hydrogen bonding of all modifications are discussed.
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The authors deal with the synthesis of 3-substituted 6,7-dimethoxy-1-thiaisochroman-1,1-dioxide and 3,4-dihydro-6,7-dimethoxy-2H-1,2-benzothiazine-1,1-dioxide derivatives. The compounds in the first-named group were found to exert effects on the central nervous system, those produced by the basic amides being particularly marked, which differ from those of currently used psychopharmacological agents.