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G Lagache

Publications and source records attributed to G Lagache.

At least 19 recordsLinked to original sources
PubMed1983

[Dermatomyositis and colonic cancer. Review of the literature apropos of a case].

The authors report the case of a 56 year-old woman presenting with dermatomyositis revealing a cancer of the colon at the ganglial dissemination stage. Exeresis led to the regression of the dermatomyositis and allowed an attenuation of the steroid therapy. The muscular and cutaneous signs reappeared within six months, evidencing a metastatic hepatic dissemination. Death came within six months of the appearance of the dermatomyositis. The authors review the literature concerning dermatomyositis associated with cancers of the digestive tract in general, and of the colon in particular. This association is found in about 6 to 35% of cases of dermatomyositis, which is the most common paraneoplastic skin associated with cancers of the colon.

Colonic Neoplasms↗
PubMed1983

[Diagnostic value of the assay of beta 2 microglobulin during the monitoring of surgically-treated colorectal cancers. Comparison with carcinoembryonic antigen].

This work presents an evaluation of the diagnostic value of seric beta 2-microglobulin in the follow-up of operated colorectal cancers. Ninety-one patients were operated on with a curative intent between 1976 and 1979. These patients were followed for at least 2 years and divided in 2 groups: a) group NR: 48 patients apparently free of loco-regional recurrence and of distant metastases, b) group R: 43 patients presenting a cancerous relapse. High levels of beta 2-microglobulin were found in 21 patients of group NR (specificity: 56 p. 100) and in 25 patients of group R (sensitivity: 58 p. 100). In the same population, the specificity and the sensitivity of carcinoembryonic antigen (CEA) for the diagnosis of a relapse were 92 p. 100 and 88 p. 100 respectively. No significant statistical correlation was observed between the levels of beta 2-microglobulin and CEA. The sensitivity of the association beta 2-microglobulin + CEA was not superior to the dosage of CEA alone despite its reduced specificity (54 p. 100). These results indicate that the diagnostic value of the dosage of beta 2-microglobulin is inferior to that of CEA and is without interest for the detection of tumoral recurrence in the postoperative follow-up of colorectal cancers.

Aged↗
PubMed1983

[Colonic occlusions. Retrospective cooperative study of 497 cases].

A retrospective multicenter study involving 12 digestive surgery centers was conducted on 497 cases of colon obstruction. The most frequent cause of colon obstruction was colo-rectal cancer (71 p. cent of cases), but many other etiologies were involved, including 61 cases of torsion and 37 patients with occlusive sigmoiditis. Differential clinical and radiological features in each etiological group are discussed, the results of therapy undertaken analyzed, and a reasonable line of conduct proposed, adapted to each situation, with the objective of attempting to reduce mortality which still affects 25 p. cent of cases operated upon.

Adult↗
PubMed1981

[Is age a prognostic factor in differentiated carcinoma of the thyroid gland? (author's transl)].

Reviewing the outcome of 82 patients with differentiated carcinoma of the thyroid gland operated upon and followed up for more than 5 years, the authors were unable to find any difference between "younger" *under 45) and "older" (above 45) patients. They wonder whether the poorer prognosis of differentiated thyroid gland carcinoma in older patients could be due to to the tumour being usually more advanced in such patients at the time of diagnosis rather than to age itself. II this were the case, there would be no need to tailor the operative procedure to the patient's age.

Adenocarcinoma↗