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Biomedical subjects

G Lambert

Publications and source records attributed to G Lambert.

At least 181 records · Page 10Linked to original sources
PubMed1973

Bovine viral diarrhea virus in swine: characteristics of virus recovered from naturally and experimentally infected swine.

A noncytopathogenic field strain of bovine viral diarrhea virus (BVDV) was isolated from an Iowa farm brood sow and from her hysterectomy-derived, colostrum-deprived (HDCD) piglets. This field isolant was fully virulent for a neonatal calf. The NADL strain of BVDV was passaged through a series of HDCD piglets with no resultant loss of virulence for neonatal calves. Most of the BVD viral isolants recovered from pigs had been changed from a cytopathogenic biotype to a noncytopathogenic biotype. Circumstantial evidence points to swine as "carrier" hosts of BVDV.

Animals↗
PubMed1973

Bovine viral diarrhea virus in swine: neutralizing antibody in naturally and experimentally infected swine.

Neutralizing antibodies against bovine viral diarrhea virus (BVDV) were detected in sera of Iowa farm sows, their piglets derived by hysterectomy and in specific-pathogen-free (SPF) pigs in a closed herd. No antibodies against BVDV were detected in sera of 134 fetal pigs from 67 sows in an Iowa slaughter-house. Neutralizing antibodies against BVDV or hog cholera virus, produced experimentally in SPF pigs, were demonstrated to be due to different antigens rather than to a common antigen, although slight cross-neutralization reactions sometimes occur.

Animals↗
PubMed1973

Age dependent resistance to transmissible gastroenteritis of swine (TGE). I. Clinical signs and some mucosal dimensions in small intestine.

Pigs were exposed to transmissible gastroenteritis (TGE) virus when three days old or when 21 days old. Diarrhea was earliest in onset, most frequent, most profuse and most prolonged in the youngest group. Pigs exposed when three days old also had a higher case fatality rate than those exposed when 21 days old. The histological response of both groups to exposure was atrophy of villi and hyperplasia of crypts in jejunum and ileum. However, from days three to seven post-exposure, when most fatalities occurred in the younger group, atrophy of villi was both more intensive and extensive in the younger group. Hyperplasia of crypts was also greater and more prolonged in the younger group. Regeneration of atrophic villi was more rapid in jejunum than ileum in both groups. Results were interpreted to indicate two populations, with different rates of regeneration, in the 21-day old group. Based on this interpretation, regeneration of villi was more rapid in one population from the 21-day old group than in the three-day old group. The length of villi and depth of crypts in control pigs varied longitudinally (i.e. from site to site) in the intestine, within each age group. Length of villi and depth of crypts in control pigs also varied with age.

Age Factors↗
PubMed1973

Age dependent resistance to transmissible gastroenteritis of swine (TGE). II. Coronavirus titer in tissues of pigs after exposure.

Coronavirus titers were compared in various tissues of three-day old and 21-day old pigs after exposure to the virus of transmissible gastroenteritis (TGE). Pigs in both groups that did not die from TGE were necropsied at intervals from one to 15 days post-exposure, and their tissues assayed for viral content. Viral titers were much higher in the small intestines of the younger pigs. Viral isolations were obtained from several tissues of the younger pigs but only from the small intestines of pigs infected at 21 days of age. Levels of viral neutralizing antibodies in the serums of both age groups were comparable at similar post-exposure intervals.

Age Factors↗