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Biomedical subjects

G Langbein

Publications and source records attributed to G Langbein.

8 recordsLinked to original sources
PubMed1996

[Importation of cholera from Turkey. Case report of cholera acquired in Istanbul].

Following a short holiday in Istanbul, a 41-year-old man developed severe infectious enteritis accompanied by exsiccosis, hypokalemia and renal insufficiency. The patient was initially treated symptomatically under the assumption that he had traveller's diarrhea or Campylobacter enteritis. Finally, cholera vibrios were detected in several stool samples. Although Turkey is not considered to be endemic for cholera, a number of cases originating there have now been diagnosed in Germany. For the diagnosis of cholera, special microbiological expertise and techniques are required, and these are apparently not available in every medical laboratory. In view of the increasing spread of cholera worldwide, and the penchant of the German population for travelling abroad, diarrhea occurring after a visit to a foreign country should always prompt the physician to consider the possibility of cholera and to request relevant microbiological examinations of stool samples in a specialized laboratory.

Adult↗
PubMed1985

[Vinyl chloride induced hepatocellular carcinoma].

On the occasion of a hitherto unique observation of three hepatocellular carcinomas in workers of the same industrial plant within 7 years following long-term exposure to vinylchloride, the characteristics are discussed of a chemical carcinogenesis leading to two different malignant tumours: haemangiosarcoma and hepatocellular carcinoma. This carcinogenic sequence has been predicted by animal studies. It is not known why the transformation of hepatocytes into carcinoma is far rarer than of sinusoidal cells into sarcoma. Whereas the hepatocellular carcinoma predominantly develops in association with cirrhosis, vinyl chloride is able to cause cancer directly without other known co-carcinogenic agents. This hepatic carcinogenicity is dose-dependent. After the introduction of industrial prevention measures, a new initiation of the tumour is improbable. Nevertheless, because of its long latency period, estimated between 5 and 20 years, clinical manifestations are still possible. An early diagnosis by sonography and computertomography, possibly combined with puncture, in exposed persons or those formerly at high risk is conceivable, while laboratory data, even tumour markers are unreliable. Its fulminant course does not differ from that of other hepatocellular carcinomas and has until now hindered successful treatment.

Aged↗
PubMed1983

[Hepatocellular carcinoma after exposure to vinyl chloride].

Hepatocellular carcinoma was diagnosed already during life in a 54-year-old workman who had been exposed to high concentration of vinyl chloride due to his occupation for more than twenty years. In addition, typical early changes as seen in experimental vinyl chloride induced angiosarcoma were observed. In recent years permissible room air concentration of vinyl chloride at work have been lowered drastically. However, due to the long latency occurrence of malignant liver tumours may still be expected in persons exposed formerly. Within the search programme for such patients at risk ultrasonography and computed tomography as non-invasive methods with high accuracy are advisable.

Ascites↗
PubMed1981

[The role of acid in ulcer pain (author's transl)].

In 33 patients (duodenal ulcer 11, gastric ulcer 10, nonulcerous bulbar lesions 7, anastomotic ulcer 4, antral erosions 1), approximately 4 ml HCL 0,1 N were instilled under endoscopic view directly onto the lesion, with the purpose of eliciting patients-specific pain. Five (5) patients were test-positive; their pain was reproduced (duodenal ulcer 1, gastric ulcer 2, other bulbar lesions 2), the rest was negative. Twenty-three of the 33 patients were studied during a period of spontaneous pain, 4 exhibiting a positive test; 9 were asymptomatic, and 2 of these had a positive test. The role of acid in ulcer pain remains unclear. The pertinent literature is discussed.

Female↗