Biomedical subjects

G Lankhorst

Publications and source records attributed to G Lankhorst.

4 recordsLinked to original sources

PubMed1999

Exploring differences between subgroups of multiple sclerosis patients in health-related quality of life.

Health-related quality of life (HRQoL) questionnaires finding increasing use in medicine, but still only few publications have reported on HRQoL in patients with multiple sclerosis (MS). Because of its progressive and disabling nature, the disease has a considerable effect on HRQoL. To facilitate the interpretation of scores for the heterogeneous MS population, we explored differences between subgroups of MS out-patients (n = 90) on two HRQoL instruments: the Medical Outcome Study Short Form-36 and the Disability and Impact Profile. Three disease-related characteristics were studied: severity of MS, time since diagnosis, and MS progression in the past 6 months. The results show that each of these have an effect on one or more aspects of HRQoL. Thus, the longer the disease duration and the more severe and progressive the MS, the lower is the patient's experienced HRQoL.

Adult↗

PubMed1998

Psychological functioning in primary progressive versus secondary progressive multiple sclerosis.

Psychological functioning in two types of multiple sclerosis (MS) patients is assessed: primary progressive (PP) and secondary progressive (SP) patients. On the basis of differences in clinical course and underlying pathology we hypothesized that primary progressive patients and secondary progressive patients might have different psychological functioning. Seventy patients treated in an MS centre were examined cross-sectionally. Forty had an SP course of MS and 30 a PP course. The 33 male and 37 female patients had a mean age of 48.4 years (SD 11.2) and mean age of onset of MS of 30.7 years (SD 11.1). Patients completed questionnaires measuring among others the following aspects of psychological functioning: depression (BDI, SCL-90), anxiety (STAI, SCL-90), agoraphobia (SCL-90), somatic complaints (SCL-90), hostility (SCL-90) and attitude towards handicap (GHAS). Patients with a PP-MS scored significantly better on 5 out of 14 subscales than patients with SP-MS (p < .05). On the basis of our operationalizations of psychological functioning, the findings support the conclusion that on average 18 years after diagnosis of MS, amongst patients attending an MS unit, primary progressive patients were found to have better psychological functioning.

Adaptation, Psychological↗

PubMed1998

Reliability of two measures of health-related quality of life in patients with multiple sclerosis.

Multiple sclerosis is a chronic neurological disease which can cause a variety of symptoms (motor and sensory impairment, visual problems, bladder and bowel problems, sexual dysfunction, and decline in cognitive function). Both the Medical Outcome Study Short Form-36, a generic questionnaire regarding health-related quality of life, and the Disability and Impact Profile, a similar questionnaire developed for people with chronic diseases, are used regularly to assess patients with multiple sclerosis. Over a 6-mo. interval 187 patients with multiple sclerosis completed these questionnaires twice. Internal consistency of both questionnaires at Times 1 and 2 was .60 or above for all eight scales of the Medical Outcome Study Short Form-36 and five scales of the Disability and Impact Profile. Estimates of test-retest reliability for three scales of the Medical Outcome Study Short Form-36 were below .60, but for all scales of the Disability and Impact Profile were .60 or higher. The two questionnaires appeared to be reliable for our sample of patients with multiple sclerosis.

Adult↗

PubMed1997

Occupational therapy for patients with chronic diseases: CVA, rheumatoid arthritis and progressive diseases of the central nervous system.

A substantial proportion of the patients treated by occupational therapists have a chronic disease. The aim of this study was to describe the outlines of occupational therapy treatment for three specific groups of chronic diseases: progressive neurological diseases, cerebrovascular accident and rheumatoid arthritis. A total of 143 therapists, working in 49 occupational therapy departments in The Netherlands, were asked to complete a standard registration from based on the ICIDH. This form consisted of three sections: (a) patient characteristics, (b) occupational therapy diagnosis and treatment goals in terms of ICIDH and (c) treatment characteristics. The present study concerns 507 patients: 102 had progressive neurological diseases (PND), 338 had a CVA and 67 had rheumatoid arthritis (RA). Our results showed that each patient group was characterized by a specific treatment approach. Especially at the level of treatment programmes substantial differences between groups were observed. Besides the clear differences, similarities in approaches were found between the PND and RA group, e.g. total time spent on therapy differed largely between the PND and RA patients (both averages 6 h) and the CVA patients (average 14 h).

Adult↗