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Biomedical subjects

G Laskaris

Publications and source records attributed to G Laskaris.

At least 55 records · Page 3Linked to original sources
PubMed1985

Loss of intercellular substance antigens in oral hyperkeratosis, epithelial dysplasia, and squamous cell carcinoma.

Tissues from 20 oral squamous cell carcinomas and 32 leukoplakic lesions were investigated for the presence of intercellular substance antigens by the indirect immunofluorescent technique using sera from patients with proven pemphigus vulgaris. The leukoplakic lesions included 19 hyperkeratoses without histologic evidence of dysplasia and 13 hyperkeratoses with varying degrees of epithelial dysplasia. Oral tissues from 20 healthy subjects were included as a control group. The great majority of squamous cell carcinomas (95%) showed partial or complete loss of the intercellular substance antigen reactivity. Similarly, hyperkeratoses with dysplasia demonstrated, in 92% of the cases, decreased or complete absence of intercellular substance antigen reactivity. Furthermore, the degree of antigenic loss seemed to be directly related to the degree of cellular anaplasia. On the other hand, in the hyperkeratosis group without histologic signs of epithelial dysplasia, retention of normal intercellular substance antigenic pattern was observed in 73.7% of the cases as compared to the control specimens. The authors suggest that further studies are necessary to assess what value lies in determining the loss of epithelial antigens in predicting the malignant potential of dysplastic oral epithelium.

Antigens↗
PubMed1985

Warty dyskeratoma of the oral mucosa.

A case of oral warty dyskeratoma is presented and the literature is reviewed in brief. While warty dyskeratoma of the oral mucosa is rare, it appears to exhibit a variability of clinical appearance and to have a special predilection for keratinised mucosae exposed to friction and mechanical stress.

Darier Disease↗
PubMed1984

Molluscum contagiosum of the oral mucosa.

A case of molluscum contagiosum involving the buccal mucosa is reported. A review of the literature disclosed only two documented cases of this tumor with oral involvement, emphasizing its rare occurrence in the oral cavity.

Adult↗
PubMed1984

Maffucci's syndrome. Report of a case with oral hemangiomas.

A case of dyschondroplasia with hemangiomas (Maffucci's syndrome) is presented. The hemangiomas were located on the tongue and represented the only vascular lesions of the syndrome. A review of the literature revealed eight previous cases with oral hemangiomas.

Adult↗
PubMed1984

Eosinophilic ulcer of the oral mucosa.

Two additional cases of eosinophilic ulcer of the oral mucosa are presented. Both patients were treated with corticosteroids, with favorable results. A review of the literature provided useful information on the clinical characteristics, histologic features, method of treatment, and benign course of the lesions.

Adult↗
PubMed1983

Frequency of desquamative gingivitis in skin diseases.

In an attempt to determine the frequency of desquamative gingivitis (DG) in pemphigus vulgaris (PV), bullous pemphigoid (BP), cicatricial pemphigoid (CP), and lichen planus (LP), a large series of patients examined and classified in each group during the years 1972 to 1981 were included in this study. Analysis of the clinical data revealed that, of the four skin diseases, CP manifests as DG in 63.6 percent of the cases. Desquamative gingival lesions are less frequent in LP (25 percent) and in PV (18.4 percent). The great majority of DG patients were females (72.9 percent). Identification of the underlying causes of desquamative gingivitis is of utmost importance and is dependent upon clinical, histologic, and immunologic criteria.

Aged↗
PubMed1983

Serum immunoglobulins and complement (C'3) in oral lichen planus.

Serum immunoglobulins and complement (C'3) were determined by single radial immunodiffusion according to the method of Mancini and co-workers in fifty patients with oral lichen planus and twenty persons with clinically normal oral mucosa. Significantly increased levels of serum IgG (p less than 0.05) and a significant reduction of serum IgA concentration (p less than 0.05) in the experimental group as compared with normal controls were observed. Mean serum IgM and complement (C'3) levels were similar in patients and controls. No correlation between disease variety or extensiveness and immunoglobulin or complement levels was noticed. These results suggest that patients with oral lichen planus may have a generalized immunologic disorder in which humoral immunity is disturbed. Whether humoral immunity is of etiologic significance, contributes to the disease process, or, finally, represents an event secondary to the pathologic changes seen in the disease remains to be determined.

Adult↗
PubMed1982

Bullous pemphigoid, cicatricial pemphigoid, and pemphigus vulgaris. A comparative clinical survey of 278 cases.

The clinical features of bullous pemphigoid (BP), cicatricial pemphigoid (CP), and pemphigus vulgaris (PV), based upon examination of 278 patients during the years 1972 through 1981, are recorded. Data in relation to age, sex, site of onset, duration of the disease at the site of onset, distribution of oral, skin, and extracutaneous lesions, and time of final diagnosis are analyzed for each disease separately, and a detailed discussion in comparison with previous reports follows. Comparative evaluation of all the clinical data permitted identification of similarities and differences in the clinical manifestations within this disease group and provided an opportunity to increase our knowledge and understanding of the overall clinical behavior of these bullous diseases. Greater awareness of these entities, which very often involve the oral mucosa, in correlation with careful clinical observation is of particular importance and leads to early diagnosis and improved treatment.

Adolescent↗
PubMed1982

Direct immunofluorescence in oral lichen planus.

Direct immunofluorescent staining (DIF) was performed on biopsy specimens from thirty-five patients with oral lichen planus. The results showed fibrin deposition in all cases at the mucosal-submucosal interface, within colloid bodies (fourteen of thirty-five) and within vascular walls (five of thirty-five). Deposition of IgG, IgA and IgM was detected to a lesser extent, while complement (C3) could not be identified in any case. The significance of these findings was assessed by comparison with the IF results obtained in thirty-five biopsies from various oral diseases other than lichen planus and ten healty persons. Although the presence of fibrin deposition at the mucosal-submucosal junction, within vessels and cytoid bodies, was found to be highly characteristic of lichen planus, these findings were not specifically diagnostic. Morphologically identical deposits were also seen in lupus erythematosus. It is known at present whether immunologic reactions may play a role in the pathogenesis of lichen planus. However, the immunopathologic findings may occasionally be additional suggestive markers in the diagnosis of the disease.

Complement C3↗
PubMed1982

Verruciform xanthoma of the oral mucosa.

An additional case of verruciform xanthoma in the oral cavity is presented. The clinical and light microscopic findings in this case are similar to those previously described. In addition, the clinical features of 47 cases that could be found in the literature are summarized and discussed.

Adolescent↗
PubMed1981

Oral submucous fibrosis in a Greek female.

Submucous fibrosis of the oral cavity is a disease affecting almost exclusively the Indian race, although sporadic cases have been described in non-Indians. Its aetiology is unknown and dietary factors have been incriminated in its pathogenesis, such as chilli ingestion. In this paper we present a case of oral submucous fibrosis in a 67-year-old Greek female, who two years after initial diagnosis developed squamous cell carcinoma of the tongue. The clinical course and histological findings are described and the potential of this disease as a predisposing factor for the development of malignancies of the oral mucosa is discussed.

Aged↗
PubMed1981

Immunofluorescent study of cytologic smears in oral pemphigus: A simple diagnostic technique.

This study was undertaken in order to explore the diagnostic efficacy of the direct immunofluorescent technique for demonstration in vivo bound immunoglobulins to desquamated epithelial cells from patients with oral pemphigus. Cytologic smears were obtained with a wooden spatula from the oral lesions of thirty patients with known pemphigus vulgaris. Control smears were taken from thirty-five patients twenty suffering from various other mucosal diseases and fifteen devoid of oral lesions. The smears were stored at -30 degrees C. and prepared within 48 hours for examination by the direct immunofluorescent technique. Deposition of IgG was demonstrated in all thirty smears from the oral pemphigus lesions. None of the control smears gave positive results. These findings suggest that the direct immunofluorescent technique using cytologic smears may provide an additional simple and reliable method in the diagnosis or oral pemphigus vulgaris.

Diagnosis, Differential↗
PubMed1981

Cicatricial pemphigoid: direct and indirect immunofluorescent studies.

Oral mucosa, skin tissue, and serum samples from thirty-three patients with cicatricial pemphigoid were studied by the direct and indirect immunofluorescent techniques to determine the presence of tissue-bound and circulating antibodies. A linear continuous basement membrane zone pattern was observed in 96.9 percent of the oral mucosa biopsy specimens studied. This pattern is indistinguishable from the pattern observed in bullous pemphigoid. In 97 percent of the cases clinically healthy skin biopsy specimens were negative for basement membrane zone staining. Circulating anti-basement membrane zone antibodies were present in 36.4 percent of thirty-three patients with cicatricial pemphigoid in low titer (1:10 to 1:40), when normal oral mucosa was used as substrate. The demonstration of tissue-bound and circulating basement membrane zone antibodies in cicatricial pemphigoid morphologically identical to those found in bullous pemphigoid provides further support for the concept that the two diseases may represent variants of the same entity.

Adult↗
PubMed1981

Oral pemphigus vulgaris: an immunofluorescent study of fifty-eight cases.

Oral mucosa biopsy specimens and sera from fifty-eight patients with pemphigus vulgaris limited to the oral cavity were studied by the direct and indirect immunofluorescence technique. Direct immunofluorescence demonstrated intercellular substance (ICS) deposition of IgG, either alone or in combination with C3, IgA, and IgM, in fifty-seven out of fifty-eight (98.3 per cent) oral mucosa biopsy specimens examined. At the time of initial evaluation circulating ICS antibodies were detected in twenty-eight out of fifty-eight patients (48.3 per cent) when a compound animal epithelial tissue was used as substrate. However, when normal human oral mucosa was used as substrate, circulating ICS antibodies were observed in fifty out of fifty-eight patients (86.2 per cent). It is concluded that direct and indirect immunofluorescence is a valuable diagnostic test in the early diagnosis of oral pemphigus vulgaris. In addition, normal human oral mucosa is a more appropriate substrate than animal epithelial tissue.

Adolescent↗
PubMed1981

Immunofluorescent studies in desquamative gingivitis.

Twenty-seven patients (19 females and 8 males) with a clinically diagnosed desquamative gingivitis were used in this study. Twenty-seven additional patients with oral and skin diseases and with gingival involvement other than that of the desquamative gingivitis type served as controls. Biopsy gingival specimens were sectioned and stained with H and E. The rest of the tissue specimen was cut with a cryostat and used for immunofluorescent assays of the tissue-bound antibodies (IgG, IgA, IgM, C3 anf fibrin). Circulating antibodies were determined by using the indirect immunofluorescence method in serum samples. Normal human oral mucosa and several animal epithelial tissues were used as substrates. The immunopathologic findings suggest the diagnosis of lichen planus in the presence of linear or granular fibrin deposition at the basement membrane zone/mucosal submucosal interface with or without cytoid bodies and cicatricial pemphigoid, in the presence of circulating and/or tissue-bound immunoglobulins and C3 in a linear continuous pattern along the BMZ. It is suggested that an accurate diagnosis of the underlying disease of the desquamative gingivitis can be made on the bases of the clinical, histopathologic, immunopathologic and follow-up findings.

Adult↗
PubMed1980

Focal palmoplantar and oral mucosa hyperkeratosis syndrome: a report concerning five members of a family.

Focal palmoplantar and oral mucosa hyperkeratosis is a rare inherited disease that is transmitted as an autosomal dominant trait. Five affected members of a Greek family are described. All affected members of this family had hyperkeratosis of the palms, soles and attached gingiva. In addition, less severe hyperkeratosis was observed in areas of the oral mucosa subject to pressure and friction (palate, lateral border of the tongue, and retromolar pad). On histologic examination of biopsy material from the gingiva and the soles, severe hyperkeratosis and acanthosis were noted. Because hyperkeratotic lesions were located in areas of the oral mucosa in addition to the attached gingiva, the name Focal palmoplantar and oral mucosa hyperkeratosis syndrome is proposed.

Adult↗
PubMed1980

Immunopathology of oral mucosa in bullous pemphigoid.

The immunopathology of the oral mucosa was studied in twenty-nine patients with bullous pemphigoid. The 14 patients with simultaneous involvement of the skin and oral mucosa had positive oral mucosa biopsies by direct immunofluorescence, whereas 85.7 percent had positive skin biopsies. Of the fifteen patients with only skin lesions, 80 percent had positive oral mucosa biopsies by direct immunofluorescence, although the oral cavity was clinically free of disease. A total of 89.6 percent of the patients had positive oral mucosa biopsies, and an equal percentage had positive skin biopsies. IgG was present in the immune deposits in all positive biopsies, and in eight cases C'3 was detected as well. Circulating antibasement membrane zone antibodies were detected in 79.3 percent of the cases when a compound animal substrate was used and in 82.7 percent of the cases when healthy human oral mucosa was used as substrate.

Adult↗