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Biomedical subjects

G Lazarus

Publications and source records attributed to G Lazarus.

28 records · Page 2Linked to original sources
PubMed1980

Current knowledge on pharmacokinetics of halothane and enflurane.

Blood solubilities of halothane and enflurane are in a favourable range and differ only for 21%. There are some pharmacokinetical advantages to enflurane compared to halothane, but more because of its lower tissue/blood partition coefficient than due to the difference in blood solubility. The differences in physical behaviour are of more practical significance during recovery than during induction. With the use of enflurane recovery will be more rapid and somewhat less influenced by the duration of anesthesia and by alterations of distribution capacity. With both agents induction can be made faster by adjusting to a higher inspiratory concentration, whereas the waking-up time is commonly reduced by starting recovery from a lower alveolar concentration immediately at the end of operation. Hyperventilation in this period is limited by the resulting hypocapnia with reduced brain perfusion.

Cardiac Output↗
PubMed1977

[Intensive care in rabies. A case report (author's transl)].

A case of human rabies is reported showing a peculiar course in some respects. The lack of a satisfactory history concerning an animal bite 5 months earlier as well as a misleading psychiatric history led to difficulty and delay in reaching a diagnosis. Under intensive care, including mechanical ventilation and cardiac pacing, the disease reached a final stage, which is rarely seen. The clinical course and the pathological findings are described in detail and the etiology and prognosis of the disease are discussed. The latter remains rather hopeless de spite modern intensive care.

Adult↗
PubMed1977

[Tracheal suture under jet ventilation in a 7-year-old child (author's transl)].

Anaesthesia in a 7-year-old girl with incomplete dissection of the trachea due to stabbing is reported. After nasotracheal intubation the lesion was isolated. Then transtracheal jet ventilation through the defect was performed. Thus sufficient ventilation as well as a clear surgical field for the intratracheal suture even of the pars membranacea was garanteed. The advantages of this procedure compared with the traditional intubation are discussed.

Child↗
PubMed1977

[Heart rate of anaesthesiologists under physical and psychological professional stress (author's transl)].

The heart rate of anaesthesiologists under defined physical and psychological stress as well as during normal anaesthetic practice was studied. An acceleration of heart rate during induction and management of anaesthesia did not occur except in the presence of complicating circumstances. A phone call or a beeper alarm led to a rather ergotropic heart rate reaction (increase of 21%), especially when sleep was interrupted (increase of 75%). Locomotion for a professional reason, whether urgent or not, enhanced the heart rate up to 121/min. A simultaneous subjective feeling of psychological stress had no additional effect. The heart rate during the treatment of life-threatening situations remained at 109/min and often exceeded that of exhaustive running. The mean heart rate during the normal narcotic programe (90/min) was not uncommon and comparable with that of other surgical disciplines. However an increasing tolerance was seen with growing experience. Physical and psychological stress during the anaesthesiologist's work could be differentiated by means of heart rate except in some single observations. In the presence of both stressing factors the heart rate seems to be determined by the motor effort required.

Adult↗