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Biomedical subjects

G Le Menn

Publications and source records attributed to G Le Menn.

At least 19 recordsLinked to original sources
PubMed1995

Evaluation of detail reproduction for three die materials by using scanning electron microscopy and two-dimensional profilometry.

This study evaluated the reproduction of detail by Fuji-rock artificial stone, Epoxydent epoxy resin, and Steady-plast polyurethane resin. A polyvinyl siloxane impression was made of a disk-shaped calibration model, with etched grooves ranging from 1 to 46 microns in depth. The die materials were poured in the silicone impression of the disk, then examined with a scanning electron microscope and two-dimensional profilometer. The results revealed that the artificial stone could not reproduce details smaller than 20 microns because of the size of the crystalline structure, whereas epoxy resin and polyurethane resin accurately reproduced details of 1 to 2 microns.

Analysis of Variance↗
PubMed1993

Salt wastage, plasma volume contraction and hypokalemic paralysis in self-induced water intoxication.

Eleven episodes of severe hyponatremia secondary to hiccup-induced potomania were recorded in 3 years in a man who had essential hypertension, a low protein intake and a normal diluting ability. Paradoxical increase in hematocrit and plasma protein with acute extensive natriuresis was associated as well as urine potassium loss and hypokalemia producing paralysis in 1 episode. During a chronic water loading test, the defect in water excretion was related to a low urine solute delivery which was partially reverted by the natriuretic response to plasma volume expansion, promoting water diuresis. In acute water intoxication, this natriuretic response was exaggerated, producing a brisk water diuresis. Plasma volume was rapidly normalized but without any improvement in plasma sodium due to the concomitant negative sodium balance. Thus, water diuresis persisted until plasma volume was significantly contracted. Potassium loss appeared to be related to sodium excretion. Metabolic disturbances have not reoccurred despite persistent hiccup and potomania during 2 years of urea therapy.

Aged↗
PubMed1990

[The French ambulatory multicenter trial of Triatec: conclusions of the trial].

The multicentre ramipril trial was original in that the CEI was tested at its lowest effective dosage level. More than 80 p. 100 of the patients responded to a single-drug treatment with ramipril 5 mg per day or less. At that dosage level the drug was well tolerated and no severe or serious side-effect was noted. A relation could be demonstrated between the prevalence of cough and the dose of ramipril. The trial was carried out in a population of ambulatory patients with moderate, uncomplicated arterial hypertension (DAP between 95 and 115 mmHg and SAP less than or equal to 200 mmHg). It was conducted according to the "Good Clinical Practice" rules by 102 general practitioners, under their usual conditions of work, and this provided them with experience for further clinical studies of hypertension and with education for the managements of that disease in private practice.

Angiotensin-Converting Enzyme Inhibitors↗
PubMed1986

Acetaldehyde adducts with serum proteins are not responsible for decreased drug binding in alcoholic patients.

Decreased plasma binding of phenytoin and diazepam has previously been described in patients with alcoholic liver diseases. It has been attributed to hypoalbuminemia, endogenous displacers and/or qualitative changes in albumin such as formation of adducts with acetaldehyde, a highly reactive metabolite of ethanol. In the present report this hypothesis was tested. After treating the sera with activated charcoal to remove the endogenous displacers and adjusting albumin concentration to a constant level, the binding parameters of both drugs, phenytoin and diazepam, were determined in 14 healthy men and 16 alcoholic patients by equilibrium dialysis. In these conditions, no significant difference in the number of binding sites nor in the affinity constant was observed, which suggests that acetaldehyde adducts with proteins do not contribute, to a major extent, to the defect of drug binding observed in alcoholic patients.

Acetaldehyde↗
PubMed1985

[Binding of complement by anti-native desoxyribonucleic acid antibodies in systemic lupus erythematosus].

Antibodies directed against double-stranded (native) desoxyribonucleic acid (dsDNA) were detected by the immunofluorescence technique on Crithidia luciliae in 38 out of 58 patients with systemic lupus erythematosus (SLE) and in 22 out of 296 controls with autoimmune diseases. The SLE patients had high titers of anti-dsDNA antibodies which belonged at least to the IgG class and fixed the complement in 20 out of 38 cases. These complement-fixing antibodies differed from the others in their greater activity, as evaluated by C3 levels, and in their association with a high incidence of renal lesions.

Adolescent↗
PubMed1985

Nonorgan-specific autoantibodies and immunoglobulin allotypes in relatives of patients with monoclonal gammopathy.

Polyclonal immunoglobulin increase, rheumatoid factor, antinuclear antibodies and cold lymphocytotoxins were detected 10, 8, 7 and 8 times, respectively, in a group of these informative families (22, 17 and 29 subjects tested, respectively). Each family included at least 1 subject with a monoclonal gammopathy in addition to that of the proband. No correlation could be shown between any of these abnormalities and Gm haplotypes. Nonetheless, it is worth noting that 6 out of 41 relatives under 30 years of age had cold lymphocytotoxins.

Adolescent↗
PubMed1984

[Lambert-Eaton syndrome and myasthenia. Nosologic discussion].

The Eaton-Lambert syndrome is a presynaptic neuromuscular blockade with well-defined electrical characteristics. It contrasts with the postsynaptic neuromuscular blockade which typifies myasthenia gravis. A review of the literature shows that cases do not always perfectly fit the description by Eaton and Lambert and that both kinds of blockade may be associated as in the observation reported here. Since its first description in 1956, there have been many publications on the Eaton-Lambert syndrome. However, there are cases in which both types of blockade; i.e. myasthenic and pseudo-myasthenic, are associated and the following case-report has seemed to us worthy of interest.

Carcinoma, Small Cell↗
PubMed1984

[Gougerot-Sjögren syndrome and monoclonal immunoglobulin].

Serum electrophoresis and immunoelectrophoresis were performed in 67 patients with Sjögren's syndrome. We found a monoclonal gammapathy in 11 cases: IgG (10 cases) and IgM (1 case). 1 monoclonal gammapathy was detected in 2 of 21 patients with primary Sjögren's syndrome. All patients with monoclonal gammapathy were asymptomatic.

Adult↗
PubMed1984

Genetic variants of serum alpha-1-antitrypsin (Pi types) in a Breton population, the Bigoudens.

Pi typing was carried out by high resolution isoelectric focusing in 397 Bigoudens and in 100 non-Bigouden Bretons. Gene frequencies were computed by the gene counting method. No difference between the two groups could be demonstrated, neither was there a deviation from the expected Hardy-Weinberg distribution nor a heterogeneity between the Bigouden villages. The results were significantly different (p less than 0.02) from those reported in Normans.

Ethnicity↗
PubMed1984

[Significance of antinuclear anti-histone antibodies].

The results of routine antihistone antibody (AHA) assay in a preliminary series of 189 sera are presented. There were 23 positive tests (systemic lupus erythematosus, 8 cases; drug induced SLE, 4 cases; rheumatoid arthritis 7 cases; and multiple sclerosis, 1 case; chronic active hepatitis, 1 case; systemic sclerosis, 1 case and primary biliary cirrhosis 1 case). The results of routine assay in 5 other patients groups are reported: 30 spontaneous SLE (9 positive AHA), 63 rheumatoid arthritis (2 positive AHA), 19 Sjögren syndrome (no AHA), 11 primary biliary cirrhosis (1 positive AHA) and 7 mixed connective tissue disease (no AHA).

Adolescent↗
PubMed1984

[Serum immunoglobulins and complement fractions in protein malnutrition].

Serum immunoglobulins and some complement components (C1q, C3c, C4, factor B, C9) have been evaluated in 99 malnourished patients. The sole abnormality which seems related to protein calorie malnutrition is a C1q decrease significantly correlated to serum albumin, thyroxin binding prealbumin and retinol binding protein. The immunoglobulins modifications seem to be related to pathological conditions associated with malnutrition (sepsis, liver diseases).

Adult↗