Biomedical subjects

G Leb

Publications and source records attributed to G Leb.

At least 109 records · Page 6Linked to original sources

PubMed1976

[67Ga-whole-body-scanning for non-invasive diagnosis and observation of the course of Hodgkin's disease].

Whole body scanning with 67-Ga citrate, could stand the test as a valuable non-invasive agent for the diagnosis and course study of Hodgkin's disease. It shows a differential accuracy in various nodal and extranodal manifestations, as well as in treated and non-treated cases. The method is not capable of replacing the common diagnostic methods which has been thus far used, but it can complete and occasionally correct them. The best diagnostic information can be gained in the thorax and in extranodal manifestations, which are difficult to evaluate by conventional studies. Our own results, which were obtained by means of studies in 18 cases, are discussed in comparison with reported results in the literature.

Adult↗

PubMed1976

[Frequency distribution of an index for free thyroxin in relation to age and thyroid status].

We compared an index for free thyroxine (FT4I) between groups of patients which were formed according to the results of radioiodine testing. An elevation of free thyroxine (as measured by the FT4I) which has been reported in elderly women by other authors could not be confirmed. Overlapping between euthyroidism and hyperthyroidism was not found as disturbing as reported elsewhere, a finding which can probably be explained by the different criteria for the categories "euthyroidism" and "hyperthyroidism". A group with depressed radioiodine uptake had an unexpected high percentage of elevated FT4I. These cases may be explained as toxic goitres. The incidence of hypothyroidism (as judged by FT4I) in this group is low compared with the incidence of obvious exogenous exposure to excessive iodide. Cases presenting with a normal radioiodide uptake together with absent suppression by thyroxine administration are more often connected with a normal FT4I and are therefore believed to be euthyroid; less frequently they are truly hyperthyroid (FT4I). In patients previously treated with radioiodine an elevated FT4I is found suprisingly often. A reevaluation of the radioiodine dosage and the course of the disease in these numerous patients seems to be indicated.

Age Factors↗

PubMed1976

[Thyroxine in the treatment of euthyroid goiter and the prevention of goiter recurrence].

Patients with non-toxic goitre, or patients after an operation of non-toxic goitre, were given 75 mug thyroxine daily. The level of TSH decreased significantly only for the non-toxic goitre group. The TSH-TRH-test showed a high percentage of abnormal results, even after several months of treatment. An index for free thyroxine increased a little, but significantly. The neck sizes decreased only in the post-operative group significantly. The final scans showed a high percentage of goitres. 75 mug thyroxine is too small a dosage in these patients and 100 to 150 mug daily seem to be indicated in the above mentioned states.

Goiter↗

PubMed1975

[The value of pyrophosphate scintigraphy for the assessment of the activity of spondylarthritis ankylopoietica (author's transl)].

Seriological and scintigraphic activity was compared in 29 patients with spondylarthritis ankylopoietica (Bechterew's disease). Among our cases, 11 serologically active patients also had positive scans. the details being: cervical vertebral column in 5, thoracic vertebral column in 7 cases and the lumbar vertebral column and iliosacral joint in all 11 patients. In the group of 16 serologically inactive patients, 12 cases could be confirmed radiologically, in the remaining 4 early detection of ankylosing spondylarthritis was possible from the scintigraphic findings in combination with the clinical symptoms. The clinically suspected diagnosis of an incipient Bechterew's disease could not be justified in the remaining 2 patients who had no positive scintigraphic or serological results.

Adolescent↗

PubMed1975

[Isotope diagnostic findigs in nephroptoses].

Radiorenography, serial scans and clearance determinations using 131-I-Iodohippurate and 51-CPr-EDTA were performed on a total of 106 patients with unilateral nephroptosis. In 45 of them with pathological findings in the upright position the examination was repeated in the prone position. 19 patients underwent nephropexy and were reexamined 2 to 6 weeks there after. The results suggest that the combination of different radioisotope methods provides a valuable and sensitive means to detect posture-dependent impairment of kidney and urinary tract function and yields an additional objective basis for the selection of patients for nephropexy.

Adult↗

PubMed1975

[20 min 99mTc thyroid uptake (author's transl)].

The 20 min 99mTc thyroid uptake compares favourably with the more time consuming 24 h 131J uptake because it results in a lower radiation dose to the thyroid gland. The reliability of both methods is nearly the same. In all conditions in which the 131J uptake is altered, a similar deviation of the 99mTc uptake has been found. A single exception are patients treated with antithyroid drugs (together with thyroid hormones), who show frequently an elevated 99mTc uptake (in contrast to the 131J uptake). Prognostic conclusions have been drawn by other autors from the 99mTc uptake in similar cases.

Antithyroid Agents↗

PubMed1974