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Biomedical subjects

G Lecoin

Publications and source records attributed to G Lecoin.

2 recordsLinked to original sources

[Vascular microanastomosis by eversion and stapling using VCS forceps. Presentation of the technique and experimental evaluation of its reliability].

With the objective of further improving the reliability of microvascular anastomoses, several different procedures are now available to microsurgeons, including eversion-stapling by VCS forceps. The authors start by presenting the technique, emphasizing the need for specific instruments and compliance with certain principles determining the success of these anastomoses. In the context of an experimental protocol in the pig, on vessels measuring an average of 2.5 mm in diameter, 80 anastomoses were performed by VCS stapling-eversion and studied clinically, histologically and ultrastructurally, comparing the results to those of conventional anastomoses by approximation-suture with needle and suture. In light of the results, eversion-stapling anastomoses appear to be more reliable due to the absence of intraluminal foreign body, permanent endothelial continuity and effective re-endothelialisation before day 7.

Anastomosis, Surgical↗

Functional, behavioral, and histological changes induced by transient global cerebral ischemia in rats: effects of cinnarizine and flunarizine.

Temporary cerebral ischemia (15 min) produced by "four-vessel occlusion" in the rat causes neurological disorders, changes in behavior (locomotor hyperactivity), and neuronal damage in the neocortex, striatum, and especially the CA1 zone of the hippocampus. We have studied the effects of two calcium overload blockers, flunarizine (50 mg/kg p.o. twice a day) and cinnarizine (100 mg/kg p.o. twice a day), on these alterations. Cinnarizine markedly improved the functional abnormalities of ischemia but had little or no effect upon the neuronal damage. In contrast, flunarizine provided far greater neuronal protection but with less obvious effects upon behavioral parameters. However, there was evidence of sedation 2 h after treating animals with this dose of flunarizine that might have masked any positive effect of the drug on behavior. We conclude that under the present experimental conditions, there is no correlation between the early and late behavioral changes observed following a temporary cerebral ischemic episode and the histological damage observed in certain vulnerable neurons, particularly in the hippocampus, 72 h after the insult.

Animals↗