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Biomedical subjects

G Ledent

Publications and source records attributed to G Ledent.

8 recordsLinked to original sources
PubMed1993

Detection of secondary tumours in patients with renal carcinoma: comparative study of ex vivo ultrasonography and histological examination.

Seventeen kidneys removed from patients with renal carcinoma were submitted to ex vivo ultrasonography and then to serial pathological examination in an attempt to detect secondary tumours in apparently normal tissue. Ex vivo ultrasonography failed to reveal further tumours, but 2 lesions measuring 5 and 8 mm were found on pathological examination. These preliminary data suggest that intra-operative ultrasonography may be of little value in detecting secondary tumours in conservative surgery for renal carcinoma.

Humans↗
PubMed1993

Neutron therapy of bladder carcinoma: can a high rate of severe complications be avoided in neutron therapy?

We reviewed retrospectively a series of 58 patients with deeply invasive bladder cancer treated with fast neutron therapy (p(65) + Be) in order to evaluate its tolerance and side effects. Patients were divided into three groups according to treatment technique. Patients of group A received whole pelvis irradiation up to 50 Gy photon equivalent followed by a boost to the bladder up to 57-66 Gy photon equivalent (40-56 days). Group B patients were treated by a split course regimen of 30 Gy photon equivalent on the whole pelvis at 3-4 weeks interval (66-108 days). Group C patients, not suitable for radical treatment, received only 40-54 Gy photon equivalent (26-70 days). The overall 5-year actuarial survival rate was 30% (SE 8%). As expected, T stage was a statistically significant prognostic factor. The overall local control rate reached 21% at 4 years. Acute and late side effects were minimal to moderate. These results suggest that high-energy neutron beam treatment is at least as effective as photon beam treatment for bladder carcinoma, without a higher incidence of major side effects.

Adenocarcinoma↗
PubMed1993

[Neuroendocrine tumors of the prostate].

Neuroendocrine carcinomas of the prostate is rare and usually concern patients with an initial diagnosis of adenocarcinoma of the prostate which become refractory to hormonal treatment. Here is reported the case of a patient who presented with a primary neuroendocrine tumor of the prostate. A review of the literature shows the differences with usual adenocarcinoma and the diagnostic and therapeutic implications.

Aged↗