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Biomedical subjects

G Lenci

Publications and source records attributed to G Lenci.

14 recordsLinked to original sources
PubMed1996

[Current aspects of lymph node tuberculosis of the neck].

In 1994, the incidence of tuberculosis (Tb) in Germany is 16/ 100,000, and the incidence of extrapulmonary Tb is 2,3/100,000. The peripheral lymph nodes represent with 41% the most commonly involved extrapulmonary organ system. At present, cervical lymph node Tb is of clinical relevance on one hand in patients from endemic areas of Tb in the developing countries and on the other hand in immunocompromised patients, particularly in course of HIV infection. Diagnostic methods are discussed with special attention to fine needle biopsy; modalities and indications of imaging methods are described. The microbiological examination allows the definitive diagnostic clarification. Cervical lymph node Tb responds well to antituberculous chemotherapy. Regimens of drug combination and the duration of treatment are discussed; generally chemotherapy should be continued for at least 9 months. Indications to surgical intervention are explained. The different aspects of adenopathies caused by atypical mycobacteria are considered.

AIDS-Related Opportunistic Infections↗
PubMed1996

[Goodpasture syndrome: treatment initiation with plasmapheresis before histologic diagnostic verification].

A 28 years old male patient presented, after a history of previous recurrent hemoptysis, with diffuse bilateral air space consolidation at chest radiography (CXR). Within 48 hours, partial respiratory insufficiency developed and required intubation. On a clinical and roentgenographic basis, the diagnosis of a Goodpasture syndrome was suspected. Plasmapheresis and immunosuppressive therapy with prednisone and cyclophosphamide were started immediately. Three days after admission, macrohematuria developed and serum creatinine began to rise to a maximum of 3.9 mg/dl. Totally, 13 plasmaphereses were performed within 27 days. Clinical, laboratory and radiological findings improved markedly. 30 days after admission, the patient was discharged and followed on an outpatient basis. Serum creatinine eventually decreased to 1.1 mg/dl. Initially, circulating antibodies against glomerular basement membrane (GBM) were positive, controls remained negative. Renal biopsy was performed after the acute phase and showed glomerulonephritis and linear immunoglobulin deposition along the GBM. Radiologic findings at CXR and high resolution computed tomography are demonstrated.

Adult↗
PubMed1994

[Toxic lung damage caused by mitomycin C].

Lung toxicity is one of the rare side effects of mitomycin C (MMC), an effective antineoplastic agent. There have been only few reports on pulmonary damage after MMC monotherapy. We describe a case of a pulmonary reaction following MMC monotherapy. The patient was examined including bronchoalveolar lavage (BAL) and transbronchial lung biopsy. BAL yielded the diagnosis of a lymphocyte alveolitis with normal CD4/CD8 ratio within the T lymphocytes. Histologically a florid alveolitis was diagnosed. Radiological and CT findings including HR-CT are described.

Aged↗
PubMed1993

[Pulmonary toxicity caused by nitrofurantoin].

Nitrofurantoin is used in the treatment of, and to prevent, urinary tract infections. Since this chemotherapeutic agent was introduced in the fifties, quite a number of cases of acute and chronic pulmonary damage have been reported that were conditioned by nitrofurantoin. This is a report on three cases of pulmonary nitrofurantoin reactions, one of them acute and two chronic. All three patients were examined with the inclusion of bronchoalveolar lavage and transbronchial lung biopsy. In all three cases alveolitides of varying activity were confirmed. The radiological and CT findings are described.

Adult↗
PubMed1990

[Bronchiolitis obliterans following nitrogen dioxide (NO2) inhalation: clinical-roentgenologic-histologic study].

A case of bronchiolitis obliterans after prior inhalation of NO2 is described. The diagnosis was confirmed histologically following diagnostic thoracotomy and biopsy by means of pulmonary wedge resection. The clinical course of the case was compatible with the typical phases described in the literature, and the condition underwent complete remission following treatment with corticoids.

Air Pollutants, Occupational↗
PubMed1990

[Chylothorax in liver cirrhosis: a case report].

In a patient with decompensated liver cirrhosis, ascites and hydrothorax on the right side, a chylous transformation of the peritoneal and pleural effusions was seen. This case prompts deliberations on the spontaneous chylothorax in a rather rare disease pattern, in respect of its connection with the abdomen and especially with the cirrhosis of the liver.

Aged↗