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Biomedical subjects

G Lerebours

Publications and source records attributed to G Lerebours.

12 recordsLinked to original sources
PubMed1989

Penetration of pefloxacin into bronchial secretions.

Twelve patients, intubated for acute exacerbation of chronic obstructive pulmonary disease, received six intravenous doses of 400 mg of pefloxacin at 12-h intervals. Samples of blood and bronchial secretions were taken simultaneously, before the injection and at 0.5, 3, 6, 9, and 12 h after the end of the sixth infusion. There was a large variation in pefloxacin levels in both serum and bronchial secretions. The mean concentrations of pefloxacin in bronchial secretions ranged from 6.51 to 11.1 micrograms/ml and were higher than the corresponding concentrations in serum at all times. Of 61 bronchial specimens, 48 (79%) contained more than 8 micrograms of the antibiotic per ml.

Adult↗
PubMed1987

Serum hyaluronate in malignant pleural mesothelioma.

The diagnostic value of hyaluronate concentration in effusions of malignant mesothelioma has been extensively reported but no information is available about serum hyaluronate in patients with this cancer. Using a new enzymoimmunologic assay based on hyaluronate-hyaluronectin interaction, serum levels of hyaluronate were measured in 16 patients with malignant pleural mesothelioma, 50 patients with other pleural effusions, and 94 healthy blood donors. The mean serum hyaluronate level in patients with mesothelioma (mean, 750 micrograms/l; range, 29 to 5833 micrograms/l) was significantly higher than in patients with other pleural effusions (mean, 56 micrograms/l; range, 4 to 137 micrograms/l) and than in blood donors (mean, 24 micrograms/l; range, 0 to 94 micrograms/l). Comparison of serum hyaluronate values observed in mesotheliomas with the clinical course of the disease suggests that serum hyaluronate might increase only at an advanced stage of the cancer. Therefore, serum hyaluronate determination has probably no clinical value for early detection of malignant mesothelioma, but might be useful to evaluate the clinical course of this malignancy.

Adult↗
PubMed1987

Evolution of peripheral nerve function in hypoxaemic COPD patients taking almitrine bismesylate: a prospective long-term study.

Almitrine bismesylate has been thought to provoke peripheral neuropathies in patients with chronic obstructive pulmonary disease (COPD). However, there seems to exist alterations of peripheral nerve function in patients with COPD, who have not taken almitrine. We have therefore examined 22 patients with COPD and no other cause of peripheral neuropathy (PN), before and after 6 and 12 months of treatment with almitrine (50 mg bd). Seventy-eight similar patients, who did not take almitrine, were also studied (controls). Sixty-four per cent of controls, and 55% of almitrine patients initially had at least one neurophysiological abnormality. There was no change in the studied parameters after 6 months and one year's treatment with almitrine.

Aged↗
PubMed1979

[Membrane oxygenator in cardiac surgery. Its interest in extra-corporal circulation (E.C.C.) lasting more than three hours (author's transl)].

Retrospective analysis of 20 cases of heart surgery under extracorporeal circulation lasting more than three hours was performed to assess the foreseeable character or not of the long duration of the E.C.C., furthermore the risk and interest of prolongation of the E.C.C. when the latter is performed with a membrane oxygenator. It is difficult to foresee before the operation the onset of problems of operative technic which lengthen the duration of the operation, and the necessity to continue the perfusion owing to the impossibility of stopping the E.C.C. The minimal risk of prolonging the E.C.C. when the latter is equipped with a membrane oxygenator and when the operative difficulties are solved satisfactorily leads one to consider E.C.C. an essential factor in intensive care.

Adolescent↗
PubMedDate not supplied

[Extra-corporeal circulation. Experimental study. Comparative study of various oxygenators (author's transl)].

An experimental study of three different types of oxygenator was carried out in the dog during two hours extra corporeal circulation. The hemodynamic aspects and the characteristics of pulmonary elasticity that a previous study permitted us to choose as controls of the quality of extracorporeal perfusion, were studied. The results show that the pulmonary arterial resistances and the indices of pulmonary compliance do not recover during E.C.C. to their initial values, in the case of an E.C.C. using a bubble oxygenator. These results should be taken into consideration in the choice of the most suitable oxygenator.

Animals↗