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Biomedical subjects

G Limido

Publications and source records attributed to G Limido.

At least 19 recordsLinked to original sources
PubMed1993

The pharmacokinetics of oxcarbazepine and its active metabolite 10-hydroxy-carbazepine in healthy subjects and in epileptic patients treated with phenobarbitone or valproic acid.

The kinetics of oxcarbazepine (OXC) and its active metabolite 10-hydroxy-carbazepine (10-OH-CZ) after a single oral OXC dose (600 mg) were compared in healthy control subjects and in epileptic patients treated with phenobarbitone or sodium valproate (n = 8 in each group). In all groups, serum 10-OH-CZ concentrations were much higher than those of the parent drug. In patients on valproate, the kinetics of OXC and 10-OH-CZ did not differ significantly from those observed in controls. In patients on phenobarbitone, AUC values of both OXC and 10-OH-CZ were lower than in controls (2.9 +/- 0.4 vs 5.1 +/- 0.7 microg ml(-1) h and 89 +/- 7 vs 119 +/- 10 microg ml(-1) h respectively, means +/- s.e. mean, P < 0.05), whereas 10-OH-CZ half-lives were only marginally shorter (17 +/- 1 h vs 20 +/- 2 h, NS). These data indicate that the biotransformation of OXC and 10-OH-CZ may be accelerated by concomitant treatment with phenobarbitone but that the magnitude of this effect is unlikely to be of great clinical significance.

Administration, Oral↗
PubMed1991

[Nephrobronchial fistula].

Nephrobronchial fistula is a rare pathology both in absolute terms and in relation to the complications of renal inflammatory processes. Clinical symptoms may be varied but pulmonary complications, which may mask renal symptoms, are generally predominant; cough, hemoptysis and the expectoration of calculi are rarely found. Occasionally, as in the case reported here, the most evident sign is an infective process due to the contemporaneous fistulization of subcutaneous tissues. Instrumental diagnosis is based on chest and abdomen X-ray, fistulography, retrograde pyelography and abdominal CT. CAT may be useful above all in the study of pararenal abscesses.

Bronchial Fistula↗
PubMed1991

[MacLeod's syndrome: nosographic framework in the area of diffuse diseases of the lung. Contribution of radiographic and radioisotope studies].

The paper examines the clinical and etiopathogenetic aspects of MacLeod's syndrome. MacLeod's syndrome, more accurately known as unilateral bullous pneumodystrophy, forms part of the diffuse or localised hyperdiaphanies of the pulmonary parenchyma. Standard chest examination, inhalation and exhalation chest X-rays and stratigraphic control are useful instruments for the etiopathogenetic study of the syndrome. More specific tests include perfusion and ventilation scintigraphy, in addition to bronchography and angiopneumography.

Bronchography↗
PubMed1990

[The legislative requirements for radioprotection in dental offices equipped with apparatus for dental radiodiagnosis and orthopantomography].

The paper summarises the new legislation which is expected to be introduced concerning the use of dental radiodiagnostic and orthopantomographic equipment. The above modifications are partly the responsibility of the employer responsible for the dental practice, the qualified expert and, if present, the authorized doctor. A summary is given of the development of Italian regulations which are being brought into line with EEC standards.

Dental Offices↗
PubMed1985

[Radiographic diagnosis in the early recognition and evaluation of incapacitating sequelae of advanced rheumatoid arthritis].

Two observed cases of rheumatoid arthritis, one at an initial, the other at a very advanced stage, form the basis for a detailed report on the radiographic signs of the disease. Particular emphasis is placed on the possibilities offered by the various radiographic techniques for the evaluation of the sequelae of rheumatoid arthritis and for the early diagnosis of the disease.

Arthritis↗
PubMed1985

[Clinical and radiological diagnosis considerations on 2 cases of achalasia].

Two cases of achalasia of the lower third of the oesophagus are presented. Leucoplakia was encountered in one of the cases. The clinical, aetiopathogenic and x-ray diagnostic aspects of achalasia are described in relation to the possibility that it may be associated with neoplasia or pre-cancerous alterations. In both the above cases, early dysphagia was encountered.

Diagnosis, Differential↗
PubMed1984

[Principal complications in radiographic studies].

After an introductory review of ion radiation sickness and the problem of accidents with contrast media, the main complications in urography, cholecystocholangiography, bronchography, lymphography and computerised axial tomography are listed. The comparative frequency of such complications is deduced from a study of the literature.

Angioedema↗
PubMed1984

[Radiographic diagnostic problems in cancer of the gastric stump in subjects gastrectomized for ulcer over 10 years earlier].

On the basis of some observed cases the histological, clinical and radiological aspects of carcinoma of the gastric stump are described in detail. The condition is comparatively rare, but once it occurs, recurrences are fairly frequent and given the high mortality rate it requires prompt diagnosis. Double contrast examination of the digestive tract is a useful additional technique for this purpose.

Female↗
PubMed1984

[The contribution of radiographic and radioisotope findings to the study of multiple sclerosis with special reference to the problems of false-positive scintigraphy reports].

The diagnostic value of radiographic and radioisotopic examinations in multiple sclerosis is noted. Multiple sclerosis is clinically diagnosed. If invasive and possibly dangerous examinations are to be avoided, only computerised axial tomography can often clarify differential diagnosis from other forms causing subtentorial hypercaptation and especially from tentorial meningitis.

Amyotrophic Lateral Sclerosis↗
PubMed1981

[Quality control of hospital care or medical audit: non-juridical guarantee of quality].

After defining the meaning of "medical audit", i.e. control and guarantee of the quality of hospital treatment with absolutely no judgment connotation or idea of something that interferes in any way with the physician's professional freedom, aspects of the medical audit are summarised on the basis of American and Dutch experience. It is pointed out that the technical and medical aspects should be the initial considerations.

Hospitals↗
PubMed1981

[The rights of the hospitalized patient. A medico-social problem of major importance].

Recently many Italian regions take care of the patient's rights and some regions have made regional laws of patients rights in hospital that had been made by international associations. In the latest times also syndicate of hospital's doctors began to take care of this problem and an important symposium on patient's rights was made in Gardone in September 1980. It has been discussed about patient's right and why these rights are sometimes forgotten by those who work in hospitals.

Inpatients↗
PubMed1980

[Anatomopathological, clinical, radiological diagnostic and therapeutic aspects of intraluminal duodenal diverticulum].

Anatomopathological, clinical, therapeutical aspects of intraluminal duodenal diverticulum are analyzed. This is an illness of which are described in all literature of world about 47 to 70 cases. On intraluminal duodenal diverticulum is described with x rays examinations. The diagnosis of this illness is made by radiological and endoscopical examinations. The clinical symptoms are very poor, but many illness of duodenum, pancreas, cholecystis are associated with this.

Adult↗
PubMed1980

[Iatrogenic risks. Medicolegal and organizational problems concerning the performance of radiographic examinations with intravenous administration of contrast media].

The forensic medicine and organizational aspects of doing X-rays with i.v. contrast medium are discussed. Special attention is paid to the pathogenetic and clinicotherapeutic aspects of X-ray and contrast medium induced accidents together with the organizational problems posed by these problems in small hospitals without anaesthesia and resuscitation departments.

Contrast Media↗
PubMedDate not supplied

Comparative pharmacokinetic study of chewable and conventional carbamazepine in children.

Fifteen children (7 boys and 8 girls) with generalized tonic-clonic seizures (GTCS) and partial seizures with elementary or complex symptomatology, treated with carbamazepine (CBZ) alone (n = 7) or in combination with either phenobarbital (PB, n = 6) or clobazam (CLB, n = 2) given for at least 3 months at stable individualized doses and regimens, entered an open, within-patient, change-over study of consecutive periods, each lasting 2 weeks. During period 1, conventional CBZ was given; during period 2, a chewable CBZ formulation was substituted for conventional CBZ and given at the same total daily dosage with the same schedule as in period 1. Blood samples for measuring plasma concentration of both total CBZ and CBZ-10,11 epoxide (CBZ-E) were taken on the last day of each period. No significant difference between the two periods was noted in the mean +/- SD of Cmax, Css mean, and area under the curve (AUC) of total CBZ and CBZ-E. The two different CBZ formulations, administered at the same total daily dosage, can be considered bioequivalent.

Administration, Oral↗