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Biomedical subjects

G Lindstedt

Publications and source records attributed to G Lindstedt.

33 records · Page 2Linked to original sources
PubMed1977

On the prevalence, diagnosis and management of lithium-induced hypothyroidism in psychiatric patients.

Fifty-three psychiatric patients who had been receiving treatment with lithium continuously for more than two years were examined to estimate the prevalence of lithium-induced hypothyroidism. It was found to be 20 per cent among women. No men were affected among these patients. In order to study the characteristics of the disorder further cases were drawn from another population. One third of the patients developed hypothyroidism during their first year of treatment, others not until after 9 years. About two thirds of the female patients with hypothyroidism had thyroid antibodies. All cases with lithium-induced hypothyroidism showed elevated levels of serum thyrotropin, which in our experience is the laboratory examination of choice in these as well as other cases of "primary" hypothyroidism. Since the probability of detecting these cases at a given control visit was found to be low, we feel that such visits need not include extensive laboratory investigations. Hypothyroid patients responding well to lithium treatment should continue their medication combined with appropriate thyroxine substitution.

Female↗
PubMed1977

Chromium, cobalt and nickel in Swedish cement, detergents, mould and cutting oils.

The concentrations of chromium, cobalt and nickel in 8 brands of Swedish cement, 19 detergents, 28 unused mould oils and 28 unused cutting fluids were determined by atomic absorption spectrophotometry. The total quantity of chromium in cement was 40-115 microgram Cr/g, whereas water-soluble chromium and chromate did not exceed 20 microgram Cr/g. The cobalt concentration was 5-16 microgram Co/g and the nickel concentration 5-59 microgram Ni/g. In detergents the nickel concentration was comparatively higher than that of chromium and cobalt. The highest value observed was 5.7 microgram Ni/g. In mould oils the concentrations were low, never exceeding 1 microgram/g. In cutting fluids the concentrations were low with the exeption of one product which contained 19.4 microgram Ni/g. The clinical implications of the results are discussed and it is pointed out that investigations of used cutting fluids can provide important information concerning possible allergy risks.

Chromium↗
PubMed1975

Serum hemopexin in patients with dermatitis herpetiformis on dapsone (di(4-aminophenyl)sulphone).

Twenty patients with dermatitis herpetiformis treated with di(4-aminophenyl)-sulphone (Dapsone) were analyzed with respect to serum hemopexin concentration as well as some other haematological parameters. With one exception, there were normal concentrations of serum hemopexin when the haptoglobin and methaemoglobin concentrations were normal. Ten out of 11 patients with haptoglobin below 0.3 g/l, which is the lower limit of reference interval at this laboratory, had their hemopexin concentrations reduced to various extents. There was an inverse relationship between the concentration of serum hemopexin and blood methaemoglobin. There was no correlation between amount of Heinz bodies and the concentrations of blood methaemoglobin, serum haptoglobin or serum hemopexin. It is concluded that serum hemopexin measurement should be of value in the assessment of the severity of the haemolysis caused by the drug treatment in those cases who have a low serum haptoglobin concentration.

Adult↗
PubMed1975

Monoclonal IgG cryoglobulinemia with secondary development of glomerulonephritis and nephrotic syndrome.

A 45-year-old man developed in 1965 skin lesions on cold exposure and was found to have cryoglobulinemia due to an M-component of IgG class. Glomerular damage was first noted in 1970, and progressed to renal impairment and nephrotic syndrome during the next two years. Reduced serum levels of complement components C3 and C4 were found, indicating in vivo complement activation. Renal biopsy revealed proliferative glomerulonephritis and deposition of IgG and C3 along the glomerular basement membrane. Electron microscopical examination revealed a striking deposition of a 'fibrillar' or microcrystalline material in the glomerular basement membrane. This material had an ultrastructure similar to that found in the cryoprecipitate from serum. There were no tubular changes of myeloma type, neither were there any monoclonal light chains detected in the urine. So far, there are no other signs of myeloma or lymphoma. Immunosuppressive treatment with prednisone and cyclophosphamide resulted in a decrease in the serum M-component as well as a decrease in protein leakage through the glomeruli and a return to normal of glomerular filtration rate. The finding of monoclonal cryoglobulinemia, demonstrable at room temperature, in a patient developing proliferative glomerulonephritis with complement activation is unusual. It is probably that the M-component is causally related to the glomerular lesions.

Basement Membrane↗