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Biomedical subjects

G Lingg

Publications and source records attributed to G Lingg.

At least 19 recordsLinked to original sources
PubMed1998

[Osteomyelitis--imaging methods and their value].

Various imaging modalities are used in diagnosis of acute and chronic infectious endogenous osteomyelitis and exogenous ostitis. The pathophysiological changes of osteomyelitis/ostitis in the bone and surrounding soft tissue are known. Findings in plain film radiography show these changes only in relatively advanced stages of disease. Hence, plain film radiographs are useful as a basic imaging modality by excluding other differentials and as a follow-up modality under therapy. Ultrasound-using advanced technology--offers diagnostic help in acute osteomyelitis, especially in infants. The various techniques of nuclear medicine show much higher sensitivity for detecting osteomyelitis than plain film radiography, but do not permit good separation for bone involvement and infectious changes in the surrounding soft tissue. While computed tomography offers the ability to display bone and soft tissue separately, it has been widely replaced by magnetic resonance imaging using fat-suppressed sequences and paramagnetic contrast media which show the spread of the infectious changes with higher sensitivity and accuracy.

Adolescent↗
PubMed1996

[Roentgen diagnosis and computerized tomography in inflammatory rheumatic diseases. Methods with a future?].

Plain-film radiography is an important and basic element in the assessment of inflammatory rheumatic diseases. Its various uses include assessment of inflammatory osseous destruction and the activity of inflammatory changes. Furthermore, the inflammatory collateral phenomena can indicate an acute clinical phase, and the articular soft tissue swelling and tenosynovitis are shown directly and indirectly very clearly. On the other hand, high-resolution computed tomography is very capable of showing cortical structures of bone complementary to MR. In some special clinical questions and anatomical regions, especially the axial skeleton, it delivers information of high specifity, partly for definitive diagnosis and partly for planning surgical procedures. The assessment of changes in the sacroiliac joints, sternoclavicular joints and craniocervical junction are domains of computed tomography.

Arthritis, Rheumatoid↗
PubMed1990

[Paroxysmal non-hereditary angioedema].

Recurrent hypovolaemic shock had been occurring over the last five and four years, respectively, in a 53-year-old woman and a 46-year-old man who had previously been healthy. The attacks were characterized by a tension feeling and sometimes oedema in the limbs, as well as increased thirst. Within a few hours sweating, tachycardia, orthostatic complaints and shock would occur. The woman's systolic blood pressure would fall to 70 mm Hg and the pulse rate rise to 150/min. The man's blood pressure was not measurable by sphygmomanometer during his first attack. Haematocrit rose to 61 and 71.5%, haemoglobin concentration to 20.7 and 21.3 g/dl, respectively. On administration of plasma expanders all abnormal clinical and biochemical changes quickly disappeared, only to recur within weeks or months. The cause of the condition is an increased permeability of the tissue capillaries, while renal, pulmonary and cerebral vessels apparently are unaffected. During ketotifen and tebonin (gingko biloba extract) administration to the man, he required no further hospitalization for nine months, after which he had three severe attacks. The woman had a severe attack of hypovolaemic shock one month on this treatment. The prognosis of capillary leak syndrome is bad.

Angioedema↗
PubMed1989

[Clinical study comparing the effectiveness and tolerance of 2 current and one new glibenclamide formulation].

In a clinical study efficacy and tolerance of Neogluconin (2.5 mg) a new galenical form of glibenclamide were compared with a conventional preparation (Euglucon 5). Neogluconin showed an improved absorption and comparable blood sugar levels at a dosage reduced by 25%. 25 outpatients suffering from Type II diabetes in a well balanced metabolic state and previously under Euglucon therapy for at least one year were changed to the new product. After 2 months of Neogluconin therapy blood sugar profiles, HbA1, C-peptide and cholesterin levels were unchanged in comparison to values determined during the previous Euglucon treatment. This confirms that Neogluconin produces a comparable favorable blood glucose lowering effect despite a 25% reduction in dosage.

Aged↗
PubMed1986

[X-ray morphology and pathologic anatomy of osteoblastoma].

Between 1974 and 1984, 24 patients with osteoblastomas were entered in the bone tumour registry of the Gerhard Domagk Institute of Pathology and Institute for Clinical Radiology of Westphalia. These cases are evaluated. Osteoblastoma is a benign primary bone tumour with a peak incidence between ten and 20 years and a sex ratio of 18 males to 4 females in our series. The site of predilection is the spine (59%) with long bones in second place (32%). The tumor is mostly situated in the medulla. Radiologically it usually appears as a well demarcated translucency with a narrow rim and marginal sclerosis. Variations in radiological appearance and the histology and treatment are described. A malignant variant, the "aggressive osteoblastoma", is discussed and one case is described. The classification of these cases is considered.

Adolescent↗
PubMed1985

Megakaryoblastic micromegakaryocytic crisis in chronic myeloid leukemia.

Atypical megakaryoblasts (MKB) or megakaryocytes (MK) are occasionally present in the peripheral blood during the terminal development of chronic myeloid leukemia (CML). We report on a 49-year-old female suffering from Ph1 chromosome-positive CML with typical megakaryoblastic transformation in the peripheral blood and in the bone marrow. The small "blasts" were at the most only slightly larger and were occasionally even smaller than lymphocytes but showed megakaryoblastic or atypical megakaryocytic differentiation. The cytoplasmic cytochemical pattern of the atypical megakaryocytic cells was identical to that of large atypical thrombocytes. Platelet peroxidase was detected upon electron-microscopic (EM) examination. Immunologic characterization disclosed the presence of MK-specific antigens. When cultured in vitro on agar, the blasts transformed spontaneously into large mature MK, exhibiting characteristic cytochemical and immunological patterns. Cytogenetic examination of peripheral blood showed severe abnormalities. The patient did not respond to therapy and died 3 months after manifestation of the blast crisis.

Bone Marrow Cells↗
PubMed1985

[Reparative giant-cell granuloma of the extremities].

Giant-cell reparative granulomas are observed not infrequently in the mandible as sharply demarcated osteolytic lesions. On the other hand, these tumour-like lesions occurring in short tubular bones are rarely reported in the literature and, so far, only 27 cases have been described. We have records of five cases in the Westphalian Bone Tumour Register. The actual occurrence is probably greater if one assumes that the lesion is caused by an intra-osseous bleeding. This pathogenic mechanism is supported by histological evidence.

Adolescent↗
PubMed1985

[Diagnostic possibilities of computer tomography in spinal and paraspinal space-occupying lesions].

Characteristic CT findings of intramedullary, intradural and epidural as well as of vertebragenic and paraspinal tumours are described, basing on literature and on the authors patient material. The value of CT is discussed and compared with that of other imaging modalities. Attention is also drawn to the value of i.v. application of contrast medium and of primary or secondary CT myelography.

Brain Neoplasms↗
PubMed1985

[X-ray diagnostic concept of spondylodiscitis].

The destructive discovertebral lesions of ankylosing spondylitis are discussed. Their evaluation in the literature is compared with the newer histologic and radiologic results. The X-ray findings in rheumatoid arthritis are also presented. Using radiographs from 16 of our own patients suffering from ankylosing spondylitis and 5 with rheumatoid arthritis, we analyze the radiological appearances in question.

Female↗
PubMed1985

[CT diagnosis of soft tissue injuries in habitual shoulder dislocation].

Computed tomography can demonstrate most glenohumeral structures accurately. If the articular cavitz is filled with air, CT ist the method of choice in preoperative diagnosis to determine the capsular extension and to assess the destruction of the glenoid bone rim and glenoid labrum.

Arthrography↗
PubMed1984

[Computed tomography and the pathogenic potential of the medial parapatellar fold].

The anatomy of the synovial folds of the knee joint is described. Autopsy material and the authors' clinical experience are discussed and compared with the literature. CT is superior to conventional arthrography for demonstrating the synovial folds, even when Knutson's technique is used. The morphology of the plica and its relationship to chondropathia of the patella is discussed.

Cadaver↗
PubMed1984

Exocytotic exposure and retrieval of membrane antigens of chromaffin granules: quantitative evaluation of immunofluorescence on the surface of chromaffin cells.

The exocytotic exposure of antigens of chromaffin granule membranes was studied with chromaffin cells isolated from bovine adrenal medulla. Antigens on the cell surface were visualized by indirect membrane immunofluorescence employing antisera against glycoprotein III and dopamine beta-hydroxylase. With unstimulated cells, only weak immunofluorescence on the cell surface was observed, whereas stimulated cells (with carbachol or Ba2+) exhibited much stronger reactions. In all cases the staining appeared as dots and patches. To quantitatively prove these observations, we analyzed the immunostained cells using a fluorescence-activated cell sorter. After stimulation, the average fluorescence intensity of the cell population was enhanced. This increase correlated with the degree of catecholamine secretion. The fluorescence intensity of stimulated cells varied over a broad range indicating that individual cells reacted variably to the secretagogues. When stimulated cells were incubated at 37 degrees C for up to 45 min after stimulation, a decrease of membrane immunofluorescence approaching that of unstimulated control cells was observed. Apparently, the membranes of chromaffin granules, which had been incorporated into the plasma membrane, were retrieved by a specific and relatively fast process. This retrieval of the antigen from the cell surface was blocked by sodium azide, but not influenced by colchicine, cytochalasin B, and trifluoperazine. The quantitative methods established in this paper should prove useful for further study of the kinetics of the exo-endocytotic cycle in secretory tissues.

Adrenal Medulla↗
PubMed1984

[Value of angiography, sonography and computer tomography in the differential diagnosis of renal space-occupying lesions].

157 space-occupying lesions of the kidneys (89 cysts, 57 malignant tumours, 8 benign tumours, 1 abscess, 1 non-traumatic bleeding and a special form of inflammation, namely, xanthogranulomatous pyelonephritis) which were observed in 2 years, were evaluated, using angiography, ultrasound and computed tomography. If a space-occupying lesion is found--mostly by I.V. urography--ultrasound should be applied next for differentiating the cyst from the solid tumour. If this is not possible, or if a solid tumour is found, the next step should be computed tomography. (Staging of carcinoma, diagnosis of angiomyolipoma or another benign tumour, eg.. a lipoma). Angiography as an invasive procedure is indicated only in cases in which ultrasound and computed tomography don't yield a diagnosis. (Possibility of pharmacoangiography and magnification angiography).

Adenocarcinoma↗
PubMed1983

[The dorsum sellae as an indicator of axial skeletal osteoporosis. The results of computer tomographic densitometry].

Computer tomographic densitometry of the dorsum sellae shows decreasing density with increasing age. This reduction does not take place evenly, but increases markedly at the age of 50. Densities below twice a standard deviation of mean values suggest that there is porosis of the axial skeleton as well. This provides an interesting and useful piece of additional information during cranial computed tomography.

Adult↗