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Biomedical subjects

G Litarczek

Publications and source records attributed to G Litarczek.

At least 19 recordsLinked to original sources
PubMed1997

Human fluid balance modelling and its treatment simulation with HIDION.

HIDION is a tanden system composed of an expert system for diagnosis of the water and electrolytic balance disturbance and a modelling program for simulation and suggestion of the needed correction. The expert system attempts to make a diagnosis mainly based on clinical symptoms and on patient history, as they are generally available for most physicians. The treatment module assists the user to establish a right strategy for re-equilibration of the fluid balance. The first aim of the system is to achieve a correct diagnosis of the disturbances of the fluid balance and a choice of therapy tactics. The second aim of the system is an educational one for both physicians and nurses. The entire system, including the expert module as well as the modelling module is developed in Turbo Prolog.

Computer Simulation↗
PubMed1992

[A scale of anesthetic-surgical risk].

An anaesthetic and surgical risk scale, which has also a predictive power regarding the lethality and the probability of occurrence of postoperative complications, is shown. The scale scores the constitutional taints, the extent of the operation, the age, the eventual emergency, the special anaesthetic risk. A second variant scores from the constitutional viewpoint each of the 7 organ systems and adds a lowering of the risk in case of an operation performed upon a system which is directly risk generating. The lethality figure was established by applying the scale to 1,945 patients operated and by recording the lethality distribution for each risk degree, after which the function which approximates most accurately the data score thus obtained is evaluated by the method of the least squares. In this way, a direct correlation of the calculated risk with the actual morbidity and complication rate, as well as with the lethality in the group of patients with complications is obtained. As the scale is achieved by the analysis of patients belonging to the field of general surgery and orthopaedics, it is valid only for this specialty.

Adolescent↗
PubMed1991

[The multiple organ failure syndrome (MOFS) and septic states].

The multiple organic failure syndrome (MOFS or MOF) is the result of a hyperergic and chaotic activation of the unspecific immune (inflammatory) system. It may be elicited, either as a consequence of hypodynamic shock phenomena with initial tissular lesions caused by a diseased peripheral vascular bed, characteristic of states of shock, or as the result of an inflammatory aseptic or septic focus occurring in the process of transformation of tissular territories diseased under the action of various factors (traumatic, thermic, immune etc.). The local inflammatory process sets in motion a series of elements of the immune apparatus, such as: polynuclear neutrophilic leucocytes, macrophages, complement, which lead, when they begin to exert an hyperergic action, to the cascade activation of these elements also outside the focus of lesion, generating disseminated lesions at the level of organs and systems of organs. The lesions have an aleatory character and affect variously organs and territories, leading finally to insufficiency phenomena with clinical expression: renal failure, pulmonary failure, encephalopathy, shock digestive tract, intravascular disseminated coagulation, state of shock initially hyperdynamic and afterwards hypodynamic, metabolic disturbances etc. The specific manifestations, the symptomatology, the therapy and the prognosis of the syndrome are described.

Humans↗
PubMed1991

[The reperfusion syndrome].

The syndrome of reperfusion is a succession of pathologic phenomena, developing at the level of a tissue that had suffered from an episode of acute ischemia and is then reperfused normally. The clinical phenomena present, characterized mainly by the appearance of an important local edema and of clear signs of tissular suffering, with sensory and motor nervous disturbances, lack of muscular contracture and, finally, phenomena of necrosis, are due to development at cellular level of some processes leading, during reperfusion and resuming of the oxygen contribution towards cells, to some chemical processes which generate an important activation of several systems with major tissular aggressiveness. The phenomena initiated locally produce here a secondary lesion that impairs the recovery of the ischemized territory, on the one hand, and the products generated in this territory activate similar phenomena in the distance, on the other hand. The primary wounded area becomes an important inflammatory focus which emits a series of mediators leading to the generalized activation of the nonspecific immune system. Both phenomena generate, in fact, a syndrome of multiple organic insufficiency that puts in danger the patient's life. Casuistics of 1506 interventions on patients with peripheral acute ischemic syndromes showed that the maximum mortality is given by tardy interventions of reperfusion (more than 12 hours) in which the syndrome of organic insufficiency appeared almost permanently.

Chronic Disease↗