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Biomedical subjects

G Logaras

Publications and source records attributed to G Logaras.

17 recordsLinked to original sources
PubMed1977

The neuromuscular blocking activity of aminodeoxykanamycin as compared with that of other aminoglycoside antibiotics.

Aminodeoxykanamycin (Kaneudomycin) as well as other members of the aminoglycoside antibiotics, has an action at the neuromuscular junction. Kanendomycin was found to be five times less potent than gentamycin, as far as their neuromuscular blocking action on the rat diaphragm is concerned. The neuromuscular blocking action on the rat diaphragm is concerned. The neuromuscular blockade produced by Kanendomycin is not reversed by neostigmine but only by calcium chloride.

Aminoglycosides↗
PubMed1977

Pharmacokinetics of five cephalosporins in healthy male volunteers.

This paper deals with data on the pharmacokinetics of cephazolin, cephalothin, cephapirin, cephaloridine and cephradine after i.m. injection of a single dose of 0.5 g in healthy male volunteers. Peak serum concentrations occurred 45 min after the administration and were 31.52 microgram/ml for cephazolin, 17.32 microgram/ml for cephaloridine, 13.98 microgram/ml for cephapirin, 9.51 microgram/ml for cephradine and 8.60 microgram/ml for cephalothin. The average half-lives were found to be 2.07, 1.80, 0.98, 1.24 and 0.97 h, respectively. The percentage of protein binding was found to be 82 for cephazolin, 59 for cephalothin, 51 for cephapirin, 31 for cephaloridine and only 10 for cephradine, half an hour after drug administration. The total urine recovery of the above cephalosporins, within 24 h, was 91.9% for cephradine, 81.9% for cephaloridine, 73.3% for cephazolin, 69.5% for cephapirin and 51.2% for cephalothin.

Adult↗
PubMed1975

[Secretion of catecholamines during pregnancy].

The excretion of total catecholamines in the urine of 18 females being in various stages of gestation was examined. These women did not take during their pregnancy any drug affecting the synthesis, storage, release, reuptake or metabolism of catecholamines. From the assessment of total catecholamines of 24 hours no statistically significant difference was observed as to the excretion of catecholamines as compared to the amount excreted by non-pregnant normal females.

Catecholamines↗