The antihypertensive efficacy of a new beta-adrenergic receptor inhibiting compound, timolol (MK-950), was evaluated using two treatment protocols: double-blind timolol vs. placebo treatment and double-blind timolol vs. propranolol (10 and 12 patients, respectively). These studies indicate that timolol significantly and safely reduced arterial pressure in mild to moderately severe essential hypertensive patients. The reduction in mean arterial pressure with timolol was equivalent to the pressure reduction with propranolol when the doses of 30 and 120 mg. per day, respectively, were used.

Adrenergic beta-Antagonists↗

PubMed1975

Mechanism of immediate hemodynamic effects of chlorothiazide.

The mechanism of the immediate hemodynamic effects of intravenous chlorothiazide (25 mg. per kilogram) was studied in 22 anesthetized open-chest dogs. Within 20 minutes after administration, cardiac output and stroke volume significantly fell; this was associated with decreased central venous and left ventricular end-diastolic pressures. That these hemodynamic effects were caused by, and dependent upon, volume loss through diuresis (eightfold increase in urine volume) was shown: by a return of these measurements to control levels when the volume loss (by diuresis) was corrected with 6 per cent Dextran; by prevention of the hemodynamic changes in chlorthiazide-treated dogs previously prepared with ureterocaval anastomosis; and by confirming these same hemodynamic effects by quantitatively equivalent hemorrhage. Thus, the immediate diuresis produced by chlorothiazide resulted in a contracted plasma volume (increased hematocrit and serum protein concentration) which, in turn, diminished cardiac venous return, central filling pressures, stroke volume, and cardiac output. There was no evidence demonstrated to indicate any direct myocardial effect or peripheral venodilation induced by thiazide.

Animals↗

PubMed1975

[Possibilities for errors in the statistical analysis of clinico-pharmacological results].

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Drug Evaluation↗

PubMed1975

[Cardiac tamponade during parenteral feeding through a subclavian catheter (author's transl)].

Among the complications of the cava catheter, cardiac perforation with subsequent cardiac tamponade is in fact the rarest but also the most serious. A perforation of the right ventricle by a cava catheter left in for 7 days is reported. The cardiac tamponade and the resulting shock syndrome could be eliminated by aspirating the fluid which had infused into the pericardial space. Subsequently, the catheter could be removed without complication. The rare but usually serious complication provides an argument for the critical indication of the cava catheter.

Adult↗

PubMed1974