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G Lorenzetti

Publications and source records attributed to G Lorenzetti.

7 recordsLinked to original sources
PubMed1990

[Chrono-risks in the episodes of fatal pulmonary thromboembolism].

A study on circadian and circannual rhythmicity in the episodes of fatal pulmonary thromboembolism has been conducted in 152 cases. The data demonstrate that the incidence in the episodes of pulmonary thromboembolism, evaluated as hour and day of onset in the clinical symptoms, presents a temporal, both circadian, and circannual distribution. The greater incidence occurs in the morning hours and in the winter season. The rhythmometric analysis by "cosinor" method showed a significant circadian and circannual rhythms in incidence of episodes of fatal pulmonary thromboembolism. The temporal distribution does not seem to be casual, but the effect of interrelationship between exogenous rhythms, such as those in the haemostatic system, endogenous rhythms, such as the cold temperature, and disease. These results demonstrate that the pulmonary thromboembolism is a disease with an high "chrono-risk", i.e. it is an expectable disease in its temporal recurrence.

Adult↗
PubMed1989

[Prognostic factors in multiple myeloma. Selection using multivariate analysis].

In order to assess the prognostic value of 15 different prognostic variables for multiple myeloma and to select the variables with the best prognostic significance, the multivariate analysis according to Cox's proportional hazard regression model was employed for a group of 80 patients followed from first diagnosis to their demise. The significant prognostic variables were bone marrow plasma cell percentage, degree of lytic bone lesions, Bence-Jones proteinuria, and haemoglobinaemia. A scoring clinical staging system was also developed, assigning the score of 1 to each of the following features: bone marrow plasma cells more than 30%, lytic bone lesions of 2-3 degrees, presence of Bence-Jones proteinuria, and haemoglobinaemia less than 110 g/l. Therefore, the score for each patient ranges from 0 to 4, and the entire group of patients with multiple myeloma is subdivided into five clinical stages: stage I = score 0, stage II = score 1, stage III = score 2; stage IV = score 3, stage V = score 4. Significant differences exist between both mean survivals (p less than 0.01), and between the survival curves (p less than 0.0001) within the five scoring clinical stages.

Adult↗
PubMed1989

[Fatal pulmonary thromboembolism: is its incidence increasing or diminishing? Analysis of 178 cases from 1971 to 1988].

A retrospective study was undertaken on 178 cases (6.9% out of 2569 autopsies) of fatal pulmonary thromboembolism, 86 males and 92 females, aged 28-87 years (mean age = 71 +/- 13), in whom pulmonary emboli were found at autopsies, performed from 1971 to 1988. Fatal pulmonary thromboemboli means that no other cause of death was found at autopsy, and emboli occluded at least 2 lobar arteries. In 43 cases (24.2%) the fatal pulmonary thromboembolism developed after surgery. Considering the percentage of the cases of fatal pulmonary thromboembolism on the number of autopsies performed every year, the incidence of this disease increased throughout the period under study. There is a significant difference in incidence of fatal pulmonary thromboembolism in the autopsies in years 1971-79 in comparison with the years 1980-88. In fact the fatal pulmonary thromboembolism cases are 5.1% from 1340 autopsies in the period 1971-79, and 8.9% from 1229 autopsies in the period 1980-88. This increase in incidence is due mainly to the fatal pulmonary thromboembolism in the medical patients (from 3.2% to 7.5%) while the postoperative cases show a slight decrease, from 1.9% to 1.4%. The mean age of patients with fatal pulmonary thromboembolism increases in the second period considered. Age and medical treatment are the most important risk factors. In spite of the increasing age of the population and the increased use of major surgery, there is a tendency to constant or decreased incidence of fatal pulmonary thromboembolism, at least in surgical patients.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMedDate not supplied

[Fatal pulmonary thromboembolism. A study of 178 cases].

A retrospective study was undertaken on 178 cases of fatal pulmonary thromboembolism, 86 males and 92 females, in whom major pulmonary emboli were found at autopsies, performed from 1971 to 1988. The 178 cases represent 6.9% from 2569 autopsies. In 43 cases (24.2%) the fatal pulmonary thromboembolism developed after surgery. The clinical diagnosis was performed in 59 cases (33.1%). The conditions at risk for fatal pulmonary thromboembolism were orthopedic surgery and radical surgery for malignancy among the surgical patients, and heart diseases and neoplasias among the medical patients. The death by fatal thromboembolism occurred in the 63.5% in the first six hours after onset of symptoms. The data suggest that recognition of those conditions which coexist with pulmonary thromboembolic disease can facilitate early diagnosis, and that when high risk is present antithrombotic prevention is of critical importance.

Adult↗
PubMedDate not supplied

[Correlation with mammography and estrogen receptors in breast neoplasms].

A comparative study of 71 patients with unilateral primary breast cancer was performed to verify a possible correlation between the mammographic findings of the cancer and the content of hormonal receptor. The Nielsen & Poulsen, and Wolfe classification were employed. Hormonal receptor content was determined using the Taylor method. The estrogen content was found to be high in type 1, intermediate in 2 and 4, and low in 3 and 5. Statistically significant difference in the estrogen receptor content was found between type 1 and others groups. Using the Wolfe classification, the hormonal content was found to be high in P1. Statistically significant difference was found between N1 and P2; N1 and DY. No relationship was found between histologic cancer type and hormonal receptor content. The Nielsen & Poulsen classification seems to be most simple and reproducible method respect of the Wolfe's parenchymal patterns. Mammographic findings could be used in selecting patients for endocrine therapy where no estrogen-receptor assay is available.

Adult↗