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Biomedical subjects

G Low

Publications and source records attributed to G Low.

25 records · Page 2Linked to original sources
PubMed1985

Dialyser reuse: a study in applied medical ethics.

A dialysis unit's introduction of automated recycling of dialysers is described. The responses of the staff and the patients are outlined, along with the pertinent ethical issues. Suggestions regarding the educational processes necessary with any innovation in long-term medical care are discussed.

Consumer Behavior↗
PubMed1985

Visual deficits and retinotoxicity caused by the naturally occurring anthelmintics, Embelia ribes and Hagenia abyssinica.

The naturally occurring anthelmintics, Embelia ribes (Enkoko) and Hagenia abyssinica (Kosso), have been reported to possibly cause optic atrophy among the Ethiopian population. In this study we found retinal pathology and defects in visual behavior in chicks treated with Enkoko, Kosso, or embelin, a crystalline extract of E. ribes. The chicks were fed orally with a high dose of 0.25 g (5 g/kg) or a low dose of 0.025 g (0.5 g/kg) per day of Enkoko or Kosso, beginning on Day 2 of life. The high dose for Enkoko was administered for 1 or 5 days, while that for Kosso was administered for 1 or 9 days. For the low dose of both Enkoko and Kosso, the dosing regime was for a period of 1, 4, or 9 days. Embelin was administered at a dose of 0.001 g (0.02 g/kg) per day for 9 days. Control chicks were force fed an equivalent amount of chick feed. Treatment with Enkoko or Kosso significantly reduced the ability of chicks to detect a moving bead introduced into the peripheral field of vision. The degree of constriction of the visual field for detection was dependent upon the total amount of drug administered. Performance on a visual discrimination task, which required discrimination of feed grains from pebbles, was also impaired in chicks treated with total doses of 0.200 and 0.250 g of Enkoko or Kosso. Thus, the extent of deficit in visually guided tasks was found to be dose dependent. The visual deficits observed in Enkoko-treated chicks were mimicked by embelin, which suggests that embelin may be responsible for the visual defects. Anatomical evidence of degeneration of ganglion cells was found in retinae exposed to high doses of Enkoko (1.25 g) and Kosso (2.25 g). However, no retinal lesions were detected in chicks following treatment with cumulative doses of less than 0.25 g of Enkoko or Kosso. Similarly, retinal pathology was not observed in embelin-exposed retinae.

Administration, Oral↗
PubMed1985

Abnormal polyunsaturated fatty acid patterns of serum lipids in alcoholism and cirrhosis: arachidonic acid deficiency in cirrhosis.

Patterns of polyunsaturated fatty acids of serum phospholipids were measured for groups of alcoholics without cirrhosis, alcoholics with cirrhosis, cirrhotics without alcoholism, and a control population. Alcoholics without cirrhosis showed increased polyunsaturated fatty acids derived from linoleic and linolenic acids, but in cirrhotics these products were decreased. Alcoholism accentuated the abnormal polyunsaturated fatty acid pattern of cirrhosis. In alcohol abuse without cirrhosis, the level of 20:3 omega 9 (20 acyl carbon atoms:3 double bonds, omega, 9 carbon atoms beyond last double bond) was significantly increased, despite adequate levels of linoleic and arachidonic acids. Liver involvement appears necessary for development of deficiencies of polyunsaturated fatty acids in serum phospholipids, of which arachidonic acid deficiency is of the largest magnitude.

Adolescent↗
PubMed1985

Consent to dialyzer reuse: is it ethically necessary?

It is argued that consent by the patient to reuse dialyzers which have been mechanically cleansed is not required provided adequate standards of practice and safety are utilized. Based on medical benefits, administrative order and cost saving we propose that specific informed consent for such reuse should not be mandatory and that it could at times be unhelpful, both to care givers and recipients.

Comprehension↗