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Biomedical subjects

G Lundemo

Publications and source records attributed to G Lundemo.

6 recordsLinked to original sources
PubMed2000

Median nerve recovery in carpal tunnel syndrome.

We studied recovery of median nerve function in operated elderly and younger patients with carpal tunnel syndrome, compared to nonoperated patients, using neurophysiological methods. Three groups were analyzed separately: elderly operated (n = 16, aged 70 to 89); younger operated (n = 83, aged 30 to 69); and nonoperated (n = 52, aged 25 to 83). The elderly operated patients had significant improvement after surgery in all sensory nerve variables and a decrease in motor distal latency. The results were comparable to the results in the younger operated patients. In the nonoperated hands, the same neurophysiological variables were also significantly improved, but to a lesser extent than in the operated hands. Overall symptom relief was better in the operated hands.

Adult↗
PubMed1992

[Congenital myotonic dystrophy].

Congenital myotonic dystrophy is a distinct entity causing severe hypotonia and other neuromuscular manifestations. The disease is usually inherited from the mother and shows a more severe course than the adult form of dystrophia myotonica. Congenital myotonic dystrophy is associated with increased perinatal mortality. We describe a case with this disorder and discuss the differential diagnosis in relation to other neuromuscular disorders causing hypotonia in early life.

Diagnosis, Differential↗
PubMed1985

Hereditary essential myoclonus.

A Scandinavian family whose members have suffered from hereditary essential myoclonus for five generations are presented. Three patients showed a uniform clinical picture with myoclonic jerks located in the upper trunk, the neck and proximal parts of the upper extremities without any other symptom or sign of CNS-dysfunction. The laboratory findings including EEG and somatosensory evoked potentials (SEP) were normal. Diagnostic criteria are discussed. Treatment was relatively ineffective.

Adult↗
PubMed1984

Beneficial effects of plasma exchange in acute inflammatory polyradiculoneuropathy.

The results of a controlled trial in which 38 patients with severe acute inflammatory polyradiculoneuropathy took part indicate that plasma exchange favourably influenced the course of the disease. Significant benefits were seen in time until onset of improvement, course of muscular weakness, improvement in disability grades over the first 2 months, and working capacity after 1 month. Cost-benefit analysis showed that the exchange treatment resulted in net financial savings. The results suggest that plasma exchange may have a role in the treatment of severe acute inflammatory polyradiculoneuropathy.

Acute Disease↗
PubMed1982

Pathophysiology of fasciculations in ALS as studied by electromyography of single motor units.

Electromyographic potentials of fasciculations were studied in ten patients with amyotrophic lateral sclerosis (ALS). The EMG recordings were made from the extensor digitorum brevis muscle. The EMG recording was so selective that only one motor unit potential appeared on maximal voluntary effort and on supramaximal electrical stimulation of the peroneal nerve. In a series of fasciculations, the shapes of the EMG potentials varied, while in a series of voluntary twitch activations of electrical nerve stimulations the EMG potentials were mainly constant. Fasciculations were followed by antidromic impulses in the test unit axon as judged from collision tests, and they persisted after lidocaine blockades of the nerve to the muscle. The findings are compatible with a conclusion of distal multifocal triggering of fasciculation. Fasciculating motor units had voluntary firing properties close to those of normal low-threshold motor units. Widespread fasciculations were abolished by a nonparalytic dose of a synthetic curare derivative (Pavulon) and augmented by administration of neostigmine in two cases. The fasciculations in ALS thus have the same characteristics as experimental fasciculations evoked by cholinesterase inhibitors, and there is reason to believe that the underlying pathophysiological mechanism is similar in the two cases.

Amyotrophic Lateral Sclerosis↗