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Biomedical subjects

G Lupidi

Publications and source records attributed to G Lupidi.

45 records · Page 3Linked to original sources
PubMed1982

[Choroidal miliary tuberculosis: fluoroangiographic study (author's transl)].

The authors have followed the evolution of disseminated choroidal tuberculosis during a period of 16 months. At the beginning of the disease, fluorescein angiography showed an early 'screen effect' and later a 'focus effect'. During the later stage of the disease, the pigmented epithelium was seen to be involved as well, as demonstrated by (1) the presence of advanced pigmented chorioretinitis at the sites where the tubercles were observed at the beginning of the disease and (2) the presence of fluorescent areas early during fluorescein angiography.

Adolescent↗
PubMed1980

[Retrobulbar injection of chlorpromazine in the absolute glaucoma (author's transl)].

The retrobulbar injection of a mixture of 2,5% of chlorpromazine + 2 % of novocaïne in blind and severely painful eyes was followed by a marked improvement of the subjective simptomatology in 82,5 % of the 63 subjects tested. The averaged follow-up was 2,6 years (range within 4 months and 8 years). Safe, simple and lacking in systemic involvement, the treatment with chlorpromazine can be proposed like a valide alternative to enucleation.

Adult↗
PubMedDate not supplied

Food restriction in female Wistar rats: V. Lipid peroxidation and antioxidant enzymes in the liver.

The activities of antioxidant enzymes as well as the levels of basal and enzyme induced peroxidation have been investigated in liver of female Wistar undernourished rats. Food restriction was applied starting from the age of 3.5 months by feeding the animals on every-other-day schedule (EOD). Diet restriction prevented the age-dependent increase of basal and enzyme induced lipid peroxidation in both mitochondrial and microsomal liver membrane preparations. The activities of antioxidant enzyme, i.e. superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) of liver decreased during aging in ad libitum fed rats. In the diet conditioned animals, a small increase of SOD and a complete recovery of CAT activities were observed. Present data support that food restriction improved the protection against peroxidation, and this may be in close relationship with the life prolonging effect of such a treatment.

Journal Article↗
PubMedDate not supplied

3'-deoxyribofuranose derivatives of 1-deaza and 3-deaza-adenosine and their activity as adenosine deaminase inhibitors.

2,6-Dichloro-1-deazapurine and 2,6-dichloro-3-deazapurine were coupled with 1,2-O-diacetyl-5-O-benzoyl-3-deoxy-beta-D-ribofuranose. Deprotection of the obtained compounds and reaction with liquid ammonia gave the desired 2-chloroadenine nucleosides, which were dechlorinated to afford the corresponding 1-deaza and 3-deazaadenosine derivatives. Biological studies performed on ADA from calf intestine showed that these new nucleosides are inhibitors of the enzyme.

Adenosine↗
PubMedDate not supplied

3'-5' cAMP phosphodiesterase in pig liver nuclei.

cAMP phosphodiesterase was partially purified from pig liver nuclei and some of its properties were investigated. The enzyme is a low km PDE. Inhibition by xanthine derivatives is in line with the behaviour of PDE from other mammalian sources, while small differences are observed towards nucleotides inhibitors. The enzyme is a chromatin-bound protein although no specific location related to transcriptional function could be demonstrated.

3',5'-Cyclic-AMP Phosphodiesterases↗
PubMedDate not supplied

Inhibition of adenosine deaminase by deaza derivatives of adenosine and purine riboside.

Deaza analogs of adenosine, where carbon substitutes for nitrogen, are not substrates for adenosine deaminase (adenosine aminohydrolase EC 3.5.4.4); little is reported on their ability to be inhibitors. Among the deaza analogs of adenosine and purine riboside that we have been testing, 1-deazaadenosine proved to be the best inhibitor (Ki = 6.6 X 10(-7)M). 1-deazapurine riboside, 1,3-dedeazadenosine, 3-deazaadenosine have affinity by about two and three order of magnitude lower.

Adenosine Deaminase Inhibitors↗
PubMedDate not supplied

[The treatment of congenital obstructions of the lacrimal passages (author's transl)].

The Authors describe their method of treatment of congenital dacryocystitis. Up to 3-4 months of age the treatment consists in the use of antibiotic eye drops and message of the lacrimal sack. After this age and up to 8 months of age irrigation of the lacrimal passages is carried out. If this is unsuccessful or if the children are older a probing is performed. The Authors report the results of the probing in a series of 118 children (146 eyes). The best results are obtained when the probing is effectuated before 8 months of age. After this age the success decreases with the increase in age of the young children. There is no apprecciable difference between the unilateral and bilateral cases.

Age Factors↗
PubMedDate not supplied

Adenosine deaminase inhibitors: synthesis, diastereoisomeric resolution and biological activity of 1-(2-hydroxy-3-nonyl)-1,2,4-triazole-3-carboxamide.

The synthesis and the diastereoisomeric resolution of 9-(2-hydroxy-3-nonyl)-1,2,4-triazole-3-carboxamide (8e and 8t) were undertaken in order to investigate the structural requirements of the adenosine deaminase inhibitory site, through simplification of the purine moiety of 9-(2-hydroxy-3-nonyl)adenine (1a, EHNA). The new compounds resulted to be good inhibitors of the enzyme, the erythro isomer being more potent than the threo one (8e, Ki = 0.11 microM vs 8t, Ki = 1.4 microM). However, the triazole derivatives did not show enhancement of inhibitory activity in comparison with the previously reported imidazole analogue 1b (Ki = 0.035 microM).

Adenosine Deaminase Inhibitors↗