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Biomedical subjects

G M Barnes

Publications and source records attributed to G M Barnes.

8 recordsLinked to original sources
PubMed1979

Acohol use among older persons: findings from a Western New York State general population survey.

This report on the drinking patterns of older persons is based upon a cross-sectional probability sample of 1,041 adults aged 18 years or older living in Erie and Niagara Counties in Western New York State. The rates of drinking, heavy drinking, and alcohol-related problems were considerably lower among persons aged 60 or older than among those aged 50--59 (approaching old age), or among those aged 18--49 (the younger comparison group). Although heavy drinking was almost nonexistent among the elderly women, sizable proportions of the older men (e.g., about a quarter of the men in the 60--69 age group) were heavy drinkers. Previous reports concluding that the stresses of aging, such as widowhood and retirement, are associated with increased problem drinking were not confirmed in this study. More definitive, longitudinal research is needed to develop a better understanding of the relationships between drinking patterns and the aging process.

Adolescent↗
PubMed1978

Relationship between lymphocyte response to tetanus toxoid and age of lymphocyte donor.

An investigation of the in vitro responsiveness of peripheral blood lymphocytes to tetanus toxoid was undertaken to determine the extent to which such reactivity might reflect in vivo reactions to tetanus toxoid immunization. It was found that lymphocyte transformation in the presence of tetanus toxoid, as measured by the uptake of tritiated thymidine, did not differ significantly for the group giving local or systemic reactions to tetanus toxoid and an immune control group. However, a striking inverse relation between lymphocyte reactivity to tetanus toxoid and age of the cell donors of both groups became clear. Such an age-related decline in the in vitro responsiveness of peripheral blood lymphocytes to a specific antigen has apparently had not been reported previously in man.

Adult↗
PubMed1978

Ambulatory electrocardiography in car workers.

A previous study in a car assembly plant showed that production-line workers had a lower incidence rate of heart attacks than executive staff. In the present study some major coronary risk factors and 24-hour ambulatory electrocardiograms were investigated in two age-matched samples of 30 middle-aged men drawn from these occupations. Men with a known history of heart disease were excluded. Compared with production-line workers, executive staff on average had a higher diastolic blood pressure (P less than 0.05) and fewer took heavy exercise during their leisure time (P less than 0.05). Ventricular premature beats (VPB was also similar for each of the periods of work, leisure and sleep. Apart from isolated ectopic beats, disturbances of rhythm were uncommon, and neither VPB nor other arrhythmias appeared to be induced by occupational factors.

Adult↗
PubMed1976

A clinical trial of WRL 105 strain live attenuated influenza vaccine comparing four methods of intranasal vaccination.

A single intranasal dose of 10(7.0)EID50 recombinant WRL 105 strain live attenuated influenza vaccine was administered intranasally to 193 volunteers either as nose drops or by one of three spray devices which produced sprays of differing physical characteristics. In volunteers with homologous hemagglutinating inhibiting antibody titres of less than or equal to 20 before vaccination, seroconversion rates varied widely from 80% following the administration of drops to 71%, 57% and 28% with each of the spray devices. In the week following vaccination 16 (22%) of 74 volunteers who were found to show a fourfold or greater antibody response took analgesics to control symptoms in comparison with 4 (7%) of 58 volunteers who exhibited no serological response to vaccination (p less than 0.05). However, neither of the occurrence of upper respiratory nor systemic symptoms were significantly different in these two groups and the level of attenuation of the recombinant WRL 105 strain appears to be acceptable for future use.

Adult↗