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G M Baskakova

Publications and source records attributed to G M Baskakova.

8 recordsLinked to original sources
PubMed1981

[Insulin-heparin complex, its physiological properties].

An insulin-heparin complex was obtained in vitro. The hypoglycemic effect of insulin, included into this complex as compared with free insulin, was increased more than 2-fold when it was tested in animals with stable alloxane diabetes. Contrary to insulin, administration of the insulin-heparin complex increased the anticoagulation properties of blood and exhibited the non-enzymatic fibrinolytic activity towards the unstabilized fibrin both in presence or in absence of inhibitors of fibrinolysis, caused by plasmin.

Alloxan↗
PubMedDate not supplied

[Experimental analysis of the pathophysiological significance of the "diabetogenic factor" present in the blood of animals with alloxan diabetes].

Hyperglycemia, induced by the disorder of Langerhans' islet structure and function, and hyperuricemia caused by purine metabolism pathological changes, appeared in the animals with experimental diabetes provoked by a single alloxan injection. As a result, endogenous alloxan-like factor, forming chronic diabetogenic background in the organism, arises and persists in the blood of the animals tested. Under these conditions, heparin exerts preventive and therapeutic effects due to alloxan or endogenous alloxan-like factor binding into complexes devoid of toxic activity.

Alloxan↗