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Biomedical subjects

G M Butenko

Publications and source records attributed to G M Butenko.

50 records · Page 3Linked to original sources
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[Characteristics of changes in lipid and carbohydrate metabolism, autoimmune reactions and hemocoagulation in elderly patients with atherosclerosis at various sites].

Senile changes in the lipid and carbohydrate metabolisms as well as in the system of haemocoagulation are risk factors of the atherosclerotic process. Atherosclerosis in patients of advanced or old age assumes a general character and the incidence of the combined involvement of different vascular regions increases. The identification of the atherosclerotic process in patients of advances age is accompanied by an increase in the disturbances of the lipid and carbohydrate metabolisms in the immunological system and the system of haemocoagulation. There are differences in the degree of such metabolic disturbances in older patients which depend on the localization of the atherosclerotic process. The strongest disturbances of the lipid and carbohydrate metabolism and in the immune reactivity occur in connection with coronary and cerebral atherosclerosis. Less frequent are metabolic disturbances and impairments of the immune reactivity in the case of peripheral atherosclerosis obliterans. Obviously, it is not only general changes in the organism but also local factors that play an important part with regard to this type of localization of the process such as deteriorated trophism of the tissue, changes in the vascular wall. Although atherosclerosis is in general characterized by an increased haemocoagulation there exist differences depending on the various localizations of the vascular process.

Aged↗
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[Changes in the mechanisms of the phagocytic activity of peritoneal macrophages during aging].

A study of the phagocytic activity in young and old rats showed that the amount of functionally active cells among macrophages of the peritoneal exudate falls with ageing. The ability of macrophages to fix, absorb and digest heterologous cells (chicken erythrocytes) decreases. This decrease of phagocytic activity is to a considerable extent due to serum factors. Probably, the age changes in the macrophages functional activity play a definite role in decreasing the efficiency of defence mechanisms during senescence.

Aging↗
PubMedDate not supplied

[Role of immune complexes in the pathogenesis of atherosclerosis: age-related aspect].

The experiments on 40 young and old rabbits which were given exogenous immune complexes (IC) for a month were made to study the changes in the blood levels of circulating IC (CIC), cholesterol and lipoproteins and their relation to the degree of atherosclerotic lesions to the vessels. The old animals that had low levels of minor CIC and insignificant transient increases in blood lipids were demonstrated to develop the same vascular atherosclerotic lesions as did the young animals that had higher levels of CIC and lipids. Some old animals retained a high immunological responsiveness (high CIC levels), which was accompanied by high incidence rates and extent of aortic lipid lesions. The findings make us conclude that the role of IC in atherosclerotic responsiveness increases with age.

Aging↗